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小剂量阿帕替尼联合TACE治疗晚期肝癌临床观察

Small dose apatinib combined TACE in treatment of advanced liver cancer

来源期刊: 广州医药 | 72-75 发布时间:2021-12-17 收稿时间:2025/11/13 17:35:02 阅读量:23
作者:
关键词:
原发性肝癌阿帕替尼肝动脉栓塞化疗术生存分析
DOI:
10.3969/j.issn.1000-8535.2019.02.018
收稿时间:
2018-10-15 
修订日期:
 
接收日期:
 
引用总数:
0  
目的 观察小剂量阿帕替尼联合经肝动脉化疗栓塞术(TACE)对晚期肝癌的疗效。方法 选择2016年1月1日—2017年12月31日在我院住院治疗的晚期肝癌患者38例,将其随机分为对照组和观察组,每组19例,对照组给予TACE治疗,观察组在TACE治疗的基础上联合口服阿帕替尼(250 mg/d)。随访两组患者的存活状态,Kaplan-Meier 法计算中位生存期,并绘制生存曲线,采用log-rank法比较两组患者生存曲线的差异。结果 对照组和观察组中位生存期分别为4.3月、5.8月,两组生存曲线比较有差异(χ2=4.691,P=0.043)。结论 相比于单纯TACE治疗,小剂量阿帕替尼联合TACE方案可以延长晚期肝癌患者的生存期。
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