肺原发性肝样腺癌临床病理特征研究

来源期刊：广州医药 | 61-65 发布时间：2021-12-17 收稿时间：2025/11/13 17:29:17 阅读量：25

作者：: 王小拍,

刘寿生,

杨耀湘,

李秀博,

杨静,

杜洪,

关键词：: 肝样腺癌免疫组织化学 ARMS 临床病理特征; Hepatoid adenocarcinoma Immunohistochemistry ARMS Clinicopathologic features

DOI：: 10.3969/j.issn.1000-8535.2019.03.016

收稿时间：: 2018-12-02
修订日期：
接收日期：
引用总数：: 0

目的分析肺肝样腺癌(HAL)的临床病理特征、诊断、免疫表型、基因检测及治疗预后等。方法对1例HAL临床及影像学、组织学形态、免疫组化及基因检测结果等进行观察,并结合相关文献综合分析。结果患者为48岁吸烟男性,镜下肿瘤具有肝细胞样和腺样分化特征,血清AFP升高。免疫组化: Hepatocyte,AFP, Arginase-1均阳性,ARMS-PCR法均未检测到EGFR,ALK/ROS1,KRAS及BRAF突变。结合相关文献分析: HAL常见于有吸烟史的男性,血清AFP值升高也是该肿瘤的一个特点。肿物多见于肺上叶,体积较大,易发生淋巴结和远处转移,预后相对较差。结论 HAL非常少见,易误诊,其诊断需结合形态学特点、临床病理特征及免疫组化结果等。

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