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尼可地尔在急性心肌梗死中的研究进展

Advancement in the study of nicorandil in acute myocardial infarction

来源期刊: 广州医药 | 105-109 发布时间:2021-12-01 收稿时间:2025/11/13 17:25:56 阅读量:46
作者:
关键词:
尼可地尔急性心肌梗死无复流
NicorandilAcute myocardial infarctionNo-reflow
DOI:
10.3969/j.issn.1000-8535.2018.01.031
收稿时间:
2017-09-25 
修订日期:
 
接收日期:
 
引用总数:
0  
尼可地尔是一种ATP敏感型钾离子通道开放剂,同时兼有类硝酸酯作用,具有舒张冠脉和外周血管及通过缺血预适应对心脏起保护作用等双重功效,主要用于抗心绞痛的治疗。介于尼可地尔这种特殊结构及其作用机制能否降低急性心肌梗死患者PCI术后无复流的发生率及改善临床预后,目前临床研究仍在探索中。现就尼可地尔的作用机制、模拟的药物预适应作用、及综合作用与急性心肌梗死的关系做一综述,评估尼可地尔作为辅助药物在AMI行介入治疗中的作用及临床预后,指导临床用药。
Nicorandil is an ATP-sensitive potassium (K-ATP) channel opener, meanwhile has an effect like nitrate, has dual actions including coronary and peripheral vasodilatation and cardioprotective effects through ischemic preconditioning, mainly for the treatment of anti-angina. Whether the specific structure of nicorandil and its mechanism can reduce the incidence of no-reflow in patients with acute myocardial infarction (AMI) after PCI and improve the clinical prognosis, the current clinical research is still under investigation. We will expound mechanisms of nicorandil, drug preconditioning and its comprehensive effect. The role of nicorandil in the interventional therapy of AMI was reviewed to guide clinical medication.
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