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青蒿素类药物的抗疟机制及耐药性产生研究进展

Advances in the synthesis and antimalarial study of artemisinin and its heteroatomic derivatives

来源期刊: 广州医药 | 119-122 发布时间:2021-12-01 收稿时间:2025/11/13 17:24:25 阅读量:14
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关键词:
青蒿素分子骨架过氧基抗疟活性耐药性
ArtemisininMolecular skeletonPeroxide groupAntimalarial activityDrug resistance
DOI:
10.3969/j.issn.1000-8535.2018.02.032
收稿时间:
2017-12-13 
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引用总数:
0  
青蒿素类药物作为抗疟特效药,其特殊分子骨架和过氧基在抗疟中起着关键作用。通过损伤虫体的器膜、诱导蛋白变性、抑制ATP 蛋白6(Pf ATP6)活性等方式杀灭疟原虫。恶性疟原虫基因序列的突变和长期不规范用药均会使其产生耐药性。本文依据文献报道,对世界关于青蒿素类药物抗疟机制、耐药性的产生原因作一综述。
Artemisinin is an effective anti-malaria drug, It's special molecular framework and peroxy group play a key role in antimalarial. Plasmodium falciparum was killed by the inducing cytoplasmic organelledamage protein denaturation, inhibiting ATP6 activity. Mutations in the genetic sequence of plasmodium falciparum and long-time using drugs without rule will develop drug resistance. This article is based on the literature, do a review of the world's causes for the resistance of artemisinin to antimalarial mechanisms.
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