Cockcroft-Gault公式和中国人MDRD公式在红斑狼疮患者肾小球滤过率的评估

来源期刊：广州医药 | 15-18 发布时间：2021-12-01 收稿时间：2025/11/13 17:23:11 阅读量：80

作者：: 关昌杰,

梁鸣,

陈敢,

李剑文,

何凤,

傅君舟,

关键词：: 系统性红斑狼疮肾小球滤过率中国人MDRD公式 Cockcroft-Gault公式; Systemic lupus erythematosus Glomerular filtration rate Modification of Diet in Renal Disease equation Cockcroft-Gault equation

DOI：: 10.3969/j.issn.1000-8535.2018.02.004

收稿时间：: 2017-12-12
修订日期：
接收日期：
引用总数：: 0

目的探讨Cockcroft-Gault公式(CG公式)以及中国人MDRD公式(c-MDRD)在狼疮(SLE)患者肾小球滤过率(GFR)评估中的作用。方法本研究纳入193名SLE患者。测量肾小球滤过率(mGFR)、血清肌酐(SCr),根据cMDRD公式,以及C-G公式分别得出估算肾小球滤过率(eGFR)。从不同方面对eGFR进行评估。结果 193名患者中, mGFR中位值为75.01 mL/(min·1.73 m²),eGFR-CG中位值70.22 mL/(min·1.73 m²),eGFR-cMDRD中位值70.67 mL/(min·1.73 m²)。患者分为mGFR≥60/(n=108)和mGFR<60 mL/(min·1.73 m²)(n=85)。对于总体病人而言, CG和 c-MDRD偏差值分别为0.64和3.91 mL/(min·1.73 m²)。在精确度以及准确度上,CG均优于c-MDRD。除了mGFR<60 mL/(min·1.73 m²)组中CG偏差值稍高于c-MDRD外,CG在分组后的表现仍然优于c-MDRD。结论和中国人MDRD公式相比,CG公式更加适合用在SLE的GFR评估。

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