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利妥昔单抗治疗造血干细胞移植后血小板输注无效的临床疗效

Efficiency of treatment with rituximab in platelet transfusion refractoriness after hematopoietic stem cell transplantation

来源期刊: 广州医药 | 13-16 发布时间:2021-11-30 收稿时间:2025/11/13 17:16:28 阅读量:30
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关键词:
血小板输注无效利妥昔单抗造血干细胞移植
RituximabPlatelet transfusion refractorinessHematopoietic stem cell transplantation
DOI:
10.3969/j.issn.1000-8535.2018.06.003
收稿时间:
2018-06-20 
修订日期:
 
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引用总数:
0  
目的 观察利妥昔单抗在治疗造血干细胞移植后血小板输注无效的有效性和安全性。方法 回顾分析我院2014年1月—2017年6月收治的11例利妥昔单抗治疗的造血干细胞移植后血小板输注无效的病例资料,其中包括重型地中海贫血8例,急性髓系白血病1例,重型再生障碍性贫血2例。结果 10例造血干细胞移植后血小板输注无效患者经利妥昔单抗治疗,375 mg/m2,每周1次,2~3次后血小板输注无效的状况明显改善;1例造血干细胞移植后血小板输注无效患者接受1次利妥昔单抗治疗,仍存在血小板输注无效,最终因颅内出血死亡。结论 利妥昔单抗是治疗造血干细胞移植后血小板输注无效的一种很有效的治疗方法。
Objective The purpose of our study was to evaluate the efficacy and safety of rituximab in the treatment of platelet transfusion refractoriness after hematopoietic stem cell transplantation. Methods We retrospectively analyzed 11paitents (8 thalassemia major,2 sever aplastic anemia,and 1 acute myeloid leukemia) with platelet transfusion refractoriness after hematopoietic stem cell transplantation. All 11 patients received treatment of rituximab. Results 10 of 11 platelet transfusion refractoriness patients after hematopoietic stem cell transplantation had improvement of platelets transfusion,1 patient of 11 platelet transfusion refractoriness patients had no response and died of intracranial hemorrhage. Conclusion Rituximab is a promising treatment in patients with platelet transfusion refractoriness after hematopoietic stem cell transplantation.
1、 ROBERTS D M,JONES R B,SMITH R M,et al.Rituximab-associated hypogammaglobulinemia: incidence,predictors and outcomes in patients with multi-system autoimmune disease[J]. J Autoimmun,2015(57):60-65. ROBERTS D M,JONES R B,SMITH R M,et al.Rituximab-associated hypogammaglobulinemia: incidence,predictors and outcomes in patients with multi-system autoimmune disease[J]. J Autoimmun,2015(57):60-65.
2、 GUO L,KAPUR R,ASLAM R,et al.CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia[J]. Blood,2016,127(6):735-738. GUO L,KAPUR R,ASLAM R,et al.CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia[J]. Blood,2016,127(6):735-738.
3、 LIU W,WU D,HU T,et al.Efficiency of treatment with rituximab in platelet transfusion refractoriness: a study of 7 cases[J]. Int J Clin Exp Med,2015,8(8):14080-14084. LIU W,WU D,HU T,et al.Efficiency of treatment with rituximab in platelet transfusion refractoriness: a study of 7 cases[J]. Int J Clin Exp Med,2015,8(8):14080-14084.
4、 SAILLER L.Rituximab off label use for difficult-to-treat auto-immune diseases: reappraisal of benefits and risks[J]. Clin Rev Allergy Immunol,2008,34(1):103-110. SAILLER L.Rituximab off label use for difficult-to-treat auto-immune diseases: reappraisal of benefits and risks[J]. Clin Rev Allergy Immunol,2008,34(1):103-110.
5、 PAI S C,LO S C,LIN T S,et al.Epitope-based matching for HLA-alloimmunized platelet refractoriness in patients with hematologic diseases[J]. Transfusion,2010,50(11):2318-2327. PAI S C,LO S C,LIN T S,et al.Epitope-based matching for HLA-alloimmunized platelet refractoriness in patients with hematologic diseases[J]. Transfusion,2010,50(11):2318-2327.
6、 WANG J,XIA W,DENG J,et al,Analysis of platelet-reactive alloantibodies and evaluation of cross-match-compatible platelets for the management of patients with transfusion refractoriness[J]. Transfus Med,2018,28(1):40-46. WANG J,XIA W,DENG J,et al,Analysis of platelet-reactive alloantibodies and evaluation of cross-match-compatible platelets for the management of patients with transfusion refractoriness[J]. Transfus Med,2018,28(1):40-46.
7、 CID J,MAGNANO L,ACOSTA M,et al.Rituximab,plasma exchange and intravenous immunoglobulins as a new treatment strategy for severe HLA alloimmune platelet refractoriness[J]. Platelets,2015,26(2):190-194. CID J,MAGNANO L,ACOSTA M,et al.Rituximab,plasma exchange and intravenous immunoglobulins as a new treatment strategy for severe HLA alloimmune platelet refractoriness[J]. Platelets,2015,26(2):190-194.
8、 SOLVES P,SANZ J,FREIRIA C,et al.Factors influencing platelet transfusion refractoriness in patients undergoing allogeneic hematopoietic stem cell transplantation[J]. Ann Hematol,2018,97(1):161-167. SOLVES P,SANZ J,FREIRIA C,et al.Factors influencing platelet transfusion refractoriness in patients undergoing allogeneic hematopoietic stem cell transplantation[J]. Ann Hematol,2018,97(1):161-167.
9、 王谦明,张晓辉.造血干细胞移植术后血小板输注无效的诊治[J]. 中华内科杂志,2015,54(3):232-234. 王谦明,张晓辉.造血干细胞移植术后血小板输注无效的诊治[J]. 中华内科杂志,2015,54(3):232-234.
10、 RADIA R,PAMPHILON D.Transfusion strategies in patients undergoing stem-cell transplantation[J]. Expert Rev Hematol,2011,4(2):213-220. RADIA R,PAMPHILON D.Transfusion strategies in patients undergoing stem-cell transplantation[J]. Expert Rev Hematol,2011,4(2):213-220.
11、 LI G,LIU F,MAO X,et a1.The investigation of platelet transfusion refractory in 69 malignant patients undergoing hematopoietic stem cell transplantation[J].Transfus Apher Set,2011,45(1):21-24. LI G,LIU F,MAO X,et a1.The investigation of platelet transfusion refractory in 69 malignant patients undergoing hematopoietic stem cell transplantation[J].Transfus Apher Set,2011,45(1):21-24.
12、 LUBAN N L,MCBRIDE E,FORD J C,et a1.Transfusion medicine problems and solutions for the pediatric hematologist/oncologist[J].Pediatr Blood Cancer,2012,58(7):1106-1111. LUBAN N L,MCBRIDE E,FORD J C,et a1.Transfusion medicine problems and solutions for the pediatric hematologist/oncologist[J].Pediatr Blood Cancer,2012,58(7):1106-1111.
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