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慢性阻塞性肺疾病急性加重期患者血清PCT、IL-6、hs-CRP水平与肺功能的相关性研究

Relevant research serum PCT、IL-6、hs-CRP and pulmonary function in acute exacerbation patients with COPD

来源期刊: 广州医药 | 93-95 发布时间:2021-12-01 收稿时间:2025/11/13 17:12:55 阅读量:15
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关键词:
慢性阻塞性肺疾病降钙素原白介素6超敏C反应蛋白肺功能
DOI:
10.3969/j.issn.1000-8535.2017.03.024
收稿时间:
2017-02-22 
修订日期:
 
接收日期:
 
引用总数:
0  
目的 探讨慢性阻塞性肺疾病急性期加重期(AECOPD)患者血清降钙素原(PCT)、白介素6(IL-6)、超敏C反应蛋白(hs-CRP)水平变化及与肺功能的相关性。方法 选择121例COPD急性加重期患者为实验组研究对象,选取同期体检的80例稳定期COPD患者为对照组,比较两组患者血清PCT、IL-6、hs-CRP的差别,并对三者与COPD患者肺功能的相关性进行探讨。结果 实验组患者IL-6、hs-CRP水平显著高于对照组(P<0.05)。实验组FEV1值、FEV1%显著低于对照组(P<0.05)。Pearson分析显示,实验组hs-CRP与肺功能指标FEV1%呈负相关关系(r=-1.51,P=0.048)。结论 AECOPD患者的血清炎症因子水平明显高于COPD稳定期患者,血清炎症因子与慢阻肺患者肺功能损伤密切相关。
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