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乳腺癌组织中SIRT1的表达观察

SIRT1 expression in breast cancer

来源期刊: 广州医药 | 17-19 发布时间:2021-12-01 收稿时间:2025/11/13 17:10:33 阅读量:19
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关键词:
SITT1乳腺癌沉默信息调节因子
SIRT1Breast cancerSilent information regulator
DOI:
10.3969/j.issn.1000-8535.2017.04.004
收稿时间:
2017-02-27 
修订日期:
 
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引用总数:
0  
目的 观察乳腺癌组织中沉默信息调节因子(SIRT1)的表达并探讨其临床意义。方法 选取70例乳腺癌组织和20例乳腺纤维腺瘤组织,应用免疫组化法观察SIRI1在两组中的表达,并分析其与临床病理参数、预后之间的关系。结果 SIRT1在乳腺癌组织中和乳腺纤维腺瘤组织中的阳性表达分别为:62.9%(44/70)、35%(7/20),P<0.05;SIRT1的表达与乳腺癌的病理分期及淋巴结转移有关,P<0.05;SIRT1表达阳性和阴性患者2年无疾病进展生存率分别为40.6%和73.7%,P<0.05。结论 乳腺癌组织中SIRT1的阳性表达率较高,并与乳腺癌的发生、发展、侵袭、转移、预后有关。
Objective To investigate the sirtuin (SIRT1) expression in breast cancer and its relationship with clinicopathological parameters in breast tissue. Methods We used immunohistochemical staining (Envision two-step) to detect the expression of 70 cases of breast cancer and 20 cases of breast fibroadenoma of SIRT1. Results The positive expression of sirt1 in breast cancer and breast fibroadenoma tissues were 62.9 % (44/70) and 35 % (7/20),P<0.05. The expression of sirt1 was correlated with the pathological stage and lymph node metastasis of breast cancer, P<0.05. The 2-year survival rates of sirt1 positive and negative patients were 40.6 % and 73.7 %, respectively, P<0.05. Conclusion The positive expression rate of sirt1 in breast cancer is higher, and is related to the occurrence, development, invasion, metastasis and prognosis of breast cancer.
1、 WANG R H, SENGUPTI K, LI C, et al. Impaired DNA damage response, genome instability,and tumorigenesis in SIRT1 mutant mice[J]. Cancer Cell, 2008, 14(4): 312-323. WANG R H, SENGUPTI K, LI C, et al. Impaired DNA damage response, genome instability,and tumorigenesis in SIRT1 mutant mice[J]. Cancer Cell, 2008, 14(4): 312-323.
2、 朱春英,郭淑琴,张云良,等. 乳腺癌合并2型糖尿病患者沉默信息调节因子1表达及其意义[J]. 肿瘤研究与临床,2011,23(9):600-606. 朱春英,郭淑琴,张云良,等. 乳腺癌合并2型糖尿病患者沉默信息调节因子1表达及其意义[J]. 肿瘤研究与临床,2011,23(9):600-606.
3、 LEE H, KIM K R, NOH S J, et al. Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma[J]. Hum Pathol, 2011, 42(2): 204-213. LEE H, KIM K R, NOH S J, et al. Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma[J]. Hum Pathol, 2011, 42(2): 204-213.
4、 DENG C X. SIRT1, is it a tumor promoter or tumorsuppressor?[J]. Biol Sci, 2009, 5(2): 147-152. DENG C X. SIRT1, is it a tumor promoter or tumorsuppressor?[J]. Biol Sci, 2009, 5(2): 147-152.
5、 FIRESTEIN R, BLANDERG, MICHAN S, et al. The SIRT1 deacetylase suppresses in testinal tum origenes is and colon cancer growth[J]. PLoS One, 2008, 3(4): 20-24. FIRESTEIN R, BLANDERG, MICHAN S, et al. The SIRT1 deacetylase suppresses in testinal tum origenes is and colon cancer growth[J]. PLoS One, 2008, 3(4): 20-24.
6、 FU M, LIU M, SAUVE A A, et al. Hormonal control of and rogen receptor fun ction th rough SIRT1[J]. Mol Cell Biol, 2006, 26(1): 22-35. FU M, LIU M, SAUVE A A, et al. Hormonal control of and rogen receptor fun ction th rough SIRT1[J]. Mol Cell Biol, 2006, 26(1): 22-35.
7、 GUARANI V, POTENTE M.SIRT1: a metabolic sensor that controls blood vessel growth[J]. Curr Opin Pharmacol, 2010, 10(2): 139-145. GUARANI V, POTENTE M.SIRT1: a metabolic sensor that controls blood vessel growth[J]. Curr Opin Pharmacol, 2010, 10(2): 139-145.
8、 MOK S C,CHAN W Y,WONG K K,et al. SPARC,an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells[J]. Oncogene,1996,12(9):1895-1901. MOK S C,CHAN W Y,WONG K K,et al. SPARC,an extracellular matrix protein with tumor-suppressing activity in human ovarian epithelial cells[J]. Oncogene,1996,12(9):1895-1901.
9、 刘晓梅,于国华,张居民,等. 乳腺癌组织SPARC和VEGF表达临床意义的探讨[J]. 中华肿瘤防治杂志,2012,19(14):1061-1065. 刘晓梅,于国华,张居民,等. 乳腺癌组织SPARC和VEGF表达临床意义的探讨[J]. 中华肿瘤防治杂志,2012,19(14):1061-1065.
10、 徐东旭,徐璐,李彦君,等. SPARC蛋白在乳腺癌组织中的表达及临床意义[J]. 中国医科大学学报,2014,43(6):493-498. 徐东旭,徐璐,李彦君,等. SPARC蛋白在乳腺癌组织中的表达及临床意义[J]. 中国医科大学学报,2014,43(6):493-498.
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