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环孢素A与糖尿病的研究进展

Research on the relationship between cyclosporin A and diabetes

来源期刊: 广州医药 | 111-114 发布时间:2021-12-01 收稿时间:2025/11/13 17:10:11 阅读量:20
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关键词:
环孢素A免疫抑制剂糖尿病胰岛素
Cyclosporin AImmunosuppressorDiabetesInsulin
DOI:
10.3969/j.issn.1000-8535.2017.05.028
收稿时间:
2017-04-27 
修订日期:
 
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引用总数:
0  
环孢素A(cyclosporin A,环孢素A)是强效的免疫抑制剂,常用于抑制器官移植后的排斥反应,器官移植后新发糖尿病与免疫抑制剂的使用有关。除器官移植,环孢素A还被用于治疗其他自身免疫性疾病,例如1型糖尿病。但环孢素A对胰岛β细胞和其他多种器官有毒副作用,长期使用环孢素A会导致胰岛素抵抗和胰岛β细胞功能损伤,这也是器官移植后糖尿病(post-transplant dibetes mellitus,PTDM)的主要原因。因此在糖尿病领域环孢素A的使用需要对病情进行具体分析和仔细斟酌。
Cyclosporin A (CsA) is a powerful immunosuppressant that is widely used to prevent organ rejection and to treat several autoimmune diseases, such as type 1 diabetes mellitus. Post-transplant diabetes mellitus (PTDM) is related with immunosuppressant. Moreover, there are many toxicity and side effects of CsA on pancreatic β cell and other organs, Long-term treatment of CsA may cause insulin resistance and β cell dyfunction. That's the main reason for post-transplant dibetes mellitus (PTDM). In diabetes mellitus fields, CsA must be used carefully considered.
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