您的位置: 首页 > 2017年9月 第48卷 第5期 > 文字全文
2023年7月 第38卷 第7期11
目录

腹膜透析患者高尿酸血症的影响因素及相关性分析

Influence factors for hyperuricemia in peritoneal dialysis patients and their correlation

来源期刊: 广州医药 | 39-41 发布时间:2021-12-01 收稿时间:2025/11/13 17:09:21 阅读量:10
作者:
关键词:
腹膜透析血尿酸影响因素相关性
Peritoneal dialysisSerum uric acidInfluence factorCorrelation
DOI:
10.3969/j.issn.1000-8535.2017.05.010
收稿时间:
2017-07-14 
修订日期:
 
接收日期:
 
引用总数:
0  
目的 探讨维持性腹膜透析患者高尿酸血症的临床特点及相关影响因素。方法 收集152名腹膜透析患者,根据血尿酸情况将患者分为高尿酸血症组和正常血尿酸组,分析其临床资料。结果 高尿酸血症112例(73.7%)。高尿酸血症组的血钾、高血压史、血尿素氮、血清肌酐、血磷、iPTH、甘油三脂水平均较正常尿酸组升高(P均<0.05);而年龄、血钠、血红蛋白、血白蛋白、前白蛋白、血钙、血清铁、总蛋白、hsCRP、空腹血糖、血总胆固醇、血高密度脂蛋白胆固醇、血低密度脂蛋白胆固醇、KT/V、PET无统计学差异(P均>0.05)。血尿酸水平与血钾、血尿素氮、血磷呈正相关(P<0.05)。结论 腹膜透析患者高尿酸血症发生率高,血尿酸与血钾、血尿素氮、血磷密切相关,及时纠正高尿酸血症可以改善预后。
Objective To investigate the clinical characteristics and its related influence factors of hyperuricemia in peritoneal dialysis patients. Methods A total of 152 peritoneal dialysis patients were enrolled. Patients were classified into hyperuricemia and normal serum uric acid (SUA)groups. Factors associated with hyperuricemia were analyzed. Results Hyperuricemia occurred in 112 cases(73.7%). There were significant differences in serum potassium, the incidence of hypertension, blood urea nitrogen, serum creatinine, serum phosphorus, parathyroid hormone, triglyceride between hyperuricemia and normal SUA groups(P<0.05). There was no significant difference in age, serum sodium, hemoglobin, serum albumin, prealbumin, serum calcium, serum iron, total protein, high sensitive C-reactive protein, serum glucose, total cholesterol, high density lipoproteins, low density lipoproteins, KT/V and PET(P>0.05). SUA levels was positively correlated with serum potassium, blood urea nitrogen and serum phosphorus(P<0.05). Conclusion Hyperuricemia was common in peritoneal dialysis patients, serum potassium levels is correlated with serum potassium, blood urea nitrogen and serum phosphorus. The timely treatment of hyperuricemia may improve the prognosis of peritoneal dialysis patients.
1、 MADERO M 1, SARNAK M J, WANG X,et al. Uric acid and long-term outcomes in CKD[J]. Am J Kidney Dis, 2009, 53(5):796-803. MADERO M 1, SARNAK M J, WANG X,et al. Uric acid and long-term outcomes in CKD[J]. Am J Kidney Dis, 2009, 53(5):796-803.
2、 JOHNSON R J, NAKAGAWA T, JALAL D, et al. Uric acid and chronic kidney disease:which is chasing which?[J]. Nephrol Dial Transplant, 2013,28(9):2221-2228. JOHNSON R J, NAKAGAWA T, JALAL D, et al. Uric acid and chronic kidney disease:which is chasing which?[J]. Nephrol Dial Transplant, 2013,28(9):2221-2228.
3、 TODA A, ISHIZAKA Y, TANI M,et al. Hyperuricemia is a significant risk factorfor the onset of chronic kidney disease [J]. Nephron Clin Pract, 2014,126(1):33-38. TODA A, ISHIZAKA Y, TANI M,et al. Hyperuricemia is a significant risk factorfor the onset of chronic kidney disease [J]. Nephron Clin Pract, 2014,126(1):33-38.
4、 LI L, YANG C, ZHAO Y, et al.Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: a systematic review and meta-analysis based on observational cohort studies [J]. BMC Nephrol, 2014, 15(1):1-12. LI L, YANG C, ZHAO Y, et al.Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: a systematic review and meta-analysis based on observational cohort studies [J]. BMC Nephrol, 2014, 15(1):1-12.
5、 DONG J, HAN Q F, ZHU T Y, et al.The associations of uric acid, cardiovas-cular and all-cause mortality in peritoneal dialysis[J]. PLoS One,2014, 9(1):e82342. DONG J, HAN Q F, ZHU T Y, et al.The associations of uric acid, cardiovas-cular and all-cause mortality in peritoneal dialysis[J]. PLoS One,2014, 9(1):e82342.
6、 XIA X, HE F, WU X, et al. Relationship between serum uric acid and all-cause and cardiovascular mortality in patients treated with peritoneal dialysis[J]. Am J Kidney Dis, 2014, 64(2):257-264. XIA X, HE F, WU X, et al. Relationship between serum uric acid and all-cause and cardiovascular mortality in patients treated with peritoneal dialysis[J]. Am J Kidney Dis, 2014, 64(2):257-264.
7、 PARK J T, KIM D K, CHANG T I, et al. Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients[J]. Nephrol Dial Transplant, 2009, 24 (11): 3520-3525. PARK J T, KIM D K, CHANG T I, et al. Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients[J]. Nephrol Dial Transplant, 2009, 24 (11): 3520-3525.
8、 MADERO M, SARNAK M J, WANG X, et al. Uric acid and long-term outcomes in CKD[J]. Am J Kidney Dis, 2009, 53(5):796-803. MADERO M, SARNAK M J, WANG X, et al. Uric acid and long-term outcomes in CKD[J]. Am J Kidney Dis, 2009, 53(5):796-803.
9、 CHONCHOL M, SHLIPAK M G, KATZ R, et al. Relationship of uric acid with progression of kidney disease[J]. Am J Kidney Dis, 2007,50(2):239-247. CHONCHOL M, SHLIPAK M G, KATZ R, et al. Relationship of uric acid with progression of kidney disease[J]. Am J Kidney Dis, 2007,50(2):239-247.
10、 RICHARD E,RIESELBACHM D, THOMAS H, et al. Influence of the kidney upon urate homeostasis in health and disease[J]. Am J Med,1974,56(5):665-675. RICHARD E,RIESELBACHM D, THOMAS H, et al. Influence of the kidney upon urate homeostasis in health and disease[J]. Am J Med,1974,56(5):665-675.
11、 ISEKI K, IKEMIYA Y, INOUE T, et al. Significance of hyperuricemia as a risk factor for developing ESRD in ascreened cohort[J]. Am J kidney Dis, 2004, 44(4): 642-650. ISEKI K, IKEMIYA Y, INOUE T, et al. Significance of hyperuricemia as a risk factor for developing ESRD in ascreened cohort[J]. Am J kidney Dis, 2004, 44(4): 642-650.
上一篇
下一篇
出版者信息








《广州医药》公众号
目录