血清胃蛋白酶原对胃癌筛查价值的探讨

来源期刊：广州医药 | 24-26 发布时间：2021-11-30 收稿时间：2025/11/13 17:05:40 阅读量：8

作者：: 江堤,

苏剑东,

张莉,

刘美红,

乐有林,

廖素环,

关键词：: 血清胃蛋白酶原胃癌筛查酶联免疫吸附试验; Serum pepsinogen PG Gastric cancer Screening ELASE

DOI：: 10.3969/j.issn.1000-8535.2016.01.008

收稿时间：: 2015-08-31
修订日期：
接收日期：
引用总数：: 0

目的探讨血清胃蛋白酶原在胃癌筛查中的价值。方法用ELISA方法对1102名患者血清PG水平进行检测,并行内镜病理组织学检查,采用ROC曲线确定PG筛查胃癌的最佳界定值。结果与对照组、萎缩性胃炎组、胃良性溃疡组相比,早期胃癌组、进展期胃癌组PGI、PGR下降(P＜0.05),进展期胃癌组PGI、PGR较早期胃癌组下降(P＜0.05)。与对照组相比,早期胃癌组、进展期胃癌组、胃良性溃疡组PGII升高(P＜0.05)。PGI及PGR在ROC曲线下面积为0.920和0.831,对胃癌的诊断价值较高。PGI≤71.50 μg/L或PGR≤4.50作为筛查标准时,对胃癌高危人群筛查的灵敏度为83.33%,特异度为82.25%。结论血清PGI、PGR在不同胃部病变中的表达水平不一致,对胃癌的早期筛查和早期诊断具有重要价值。PGI≤71.50 μg/L或PGR≤4.50是东莞地区筛查胃癌较合适的界定值。

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