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胃癌组织miR-9的表达及其与临床病理的关系

The correlation between miR-9 expression and clinicopathology in gastric carcinoma

来源期刊: 广州医药 | 8-10 发布时间:2021-11-30 收稿时间:2025/11/13 16:59:43 阅读量:33
作者:
关键词:
胃肿瘤临床病理学逆转录聚合酶链反应miR-9
Gastric neoplasmsClinicopathologyReverse transcriptase polymerase chain reactionmiR-9
DOI:
10.3969/j.issn.1000-8535.2016.03.003
收稿时间:
2015-02-15 
修订日期:
 
接收日期:
 
引用总数:
0  
目的 观察miR-9在胃癌组织中的表达水平及其与临床病理的相关性。方法 采用实时荧光定量PCR方法分别检测28例胃癌及正常胃组织中miR-9的表达水平,并分析其表达情况与临床病理资料的关系。结果 胃癌组织miR-9的表达水平[0.0078(0.0031~0.0142)]显著低于相应正常胃组织[0.0177(0.0084~0.0311), P<0.05],尤其是伴淋巴结转移者[0.0021(0.0006~0.0685)]miR-9表达水平明显降低。结论 胃癌组织中miR-9低表达,且与胃癌淋巴结转移有关。
Objective To investigate the correlation between the level of miR-9 expression and clinicopathology in gastric carcinoma. Methods The expression of miR-9 in 28 cases of gastric carcinoma tissues and normal gastric tissues were detected by quantitative real-time PCR, and the relationship between the expression and clinicopathology was analyzed. Results The expression of miR-9 expression in gastric carcinoma tissues [0.0078(0.0031~0.0142)] was significantly lower compared with the corresponding normal gastric tissues [0.0177(0.0084~0.0311), P<0.05], especially in lymph node-invasive carcinoma [0.0021(0.0006~0.0685)]. Conclusion miR-9 was down regulated in gastric cancer tissues, which was significantly associated with lymph node metastasis.
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