Objective To inverstigate the types and characteristics of allergen in children in different age with allergic diseases. Methods The food and inhalant allergen-specifi IgE(SIgE) were detected by the domestic specific IgE Screening ELISA kit in 174 children with allergic diseases,and were compared among children aged ≤3 and ＞3 years. Results 72.99%(127/174) of children with allergic diseases were positive for SIgE,the common allergen were dermatophagoides pteronyssinus/dermatophagoides farina and dust. In the group of ≤3 years old,the positives rate of food allergens was 33.93%(19/56),and the positives rate of aeroallergens was 44.65%(25/56).In the group of >3 years old, the positives rate of food allergens was 41.53%(49/118), the positives rate of aeroallergens was 61.02%(72/118).96 of 127(75.59%) positive cases yielded positive result to more than 2 allergens.69 patients's SIgE levels greater were ≥ 3,the mixed allergic rate and highly allergic rate of the children aged ＞3 years were higher than the children aged ≤3 years. Conclusion The children with allergic diseases in Guangzhou area were allergic mainly to inhalant allergens,especially to dermatophagoides pteronyssinus/dermatophagoides farina and dust.Aeroallergens are becoming the allergens as children grow with ages, and probability of mixture allergy is increasing.