Objective To explore the relationship between the histories of abnormal pregnancy and chromosomal abnormality by analyzing the chromosomal karyotype in 1373 couples with histories of abnormal pregnancy(such as abortion, stillbirth and fetal malformation and so on)in order to provide genetic consultation for secondary pregnancy. Methods The venousblood samples of 1373 couples with the histories of abnormal pregnancy were obtained, and then the lymphocytes were cultured, the chromosome was prepared,G-show band was analyzed. Results Among 1373 couples(2746 cases), there were 100 cases were found with abnormal karyotype, the abnormal rate was 3.64%. There were 45 cases with reciprocal translocation, 15 cases with Robertsonian translocation, 39 cases with inversion and 1 case with loss deletion Xq chromosomal. Conclusion Chromosomal abnormality is an important reason to lead to some diseases such as abortion、stillbirth and fetal malformation and so on, the couples with histories of abnormal pregnancy should analyze the chromosomal karyotype. The couples with chromosomal abnormality who get secondary pregnancy should have prenatal diagnosis to reduce the birthrate of infants with chromosomal abnormality.