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妊娠期糖尿病孕早中期脂肪细胞因子Chemerin、RBP4水平的研究

Serum levels of the Adipokine Chemerin、RBP4 in Gestational Diabetes Mellitus

来源期刊: 广州医药 | 30-32 发布时间:2021-11-30 收稿时间:2025/11/13 16:38:37 阅读量:89
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关键词:
妊娠期糖尿病ChemerinRBP4脂肪因子
GDMChemerinRBP4Adipokine
DOI:
10.3969/j.issn.1000-8535.2015.06.009
收稿时间:
2015-07-07 
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目的 探讨GDM孕早、中期脂肪细胞因子Chemerin、RBP4水平的变化。方法 采用前瞻性研究,测定38例GDM及40例正常孕妇孕早、中期血清Chemerin、RBP4水平,分析其与胰岛素抵抗的相关性。结果 GDM组孕妇孕早、中期血清Chemerin、RBP4水平及HOMA-IR均较对照组升高,差异有统计学意义(P<0.05);两组孕妇孕中期血清Chemerin、RBP4水平均较孕早期升高,差异有统计学意义 (P<0.05);Chemerin、RBP4水平与IR成正相关,差异有统计学意义(P<0.05)。结论 GDM孕妇孕早、中期脂肪细胞因子Chemerin、RBP4水平升高,Chemerin、RBP4水平的升高与IR有一定相关性。
Objective To discuss the serum levels of the Adipokine Chemerin、RBP4 of Gestational Diabetes Mellitus(GDM) in early pregnancy and middle pregnancy. Methods In prospective study, pregnant women, venous blood was collected from 40 controls and 38 GDM during early pregnancy (9-12weeks)and middle pregnancy (22-26weeks). Serum insulin, Chemerin, RBP4 were measured by enzyme-linked immunosorbent assay (ELISA). Results Mean serum levelsof Chemerin and RBP4 were significantly higher among GDM cases compared with controls during early pregnancy and middle pregnancy(P<0.05). In two groups, Mean serum levels of Chemerin and RBP4 in middle pregnancy were significantly higher than those in early pregnancy (P<0.05).During early pregnancy and middle pregnancy, the Chemerin and RBP4 levels were positively related with HOMA-IR (P<0.05). Conclusion There is evidence of a positive association elevated Chemerin and RBP4 concentration of early pregnancy and middle pregnancy with increased GDM risk.
1、 贾忠兰,卢新,刘敏,等.妊娠糖尿病患者血浆视黄醇结合蛋白4与胰岛素抵抗的相关性分析[J]. 检验医学,2009,24(8):559-561. 贾忠兰,卢新,刘敏,等.妊娠糖尿病患者血浆视黄醇结合蛋白4与胰岛素抵抗的相关性分析[J]. 检验医学,2009,24(8):559-561.
2、 Tepper BJ, Kim YK, Shete V, et al. Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes[J]. Clin Biochem,2001,43(3):320-323. Tepper BJ, Kim YK, Shete V, et al. Serum retinol-binding protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes[J]. Clin Biochem,2001,43(3):320-323.
3、 Maghbooli Z, Hossein-Nezhad A, Mirzaei K,et al. Association between retinol-binding protein 4 concentrations and gestational diabetes mellitus and risk of developing metabolic syndrome after pregnancy [J]. Reprod Sci,2010,17(2):196. Maghbooli Z, Hossein-Nezhad A, Mirzaei K,et al. Association between retinol-binding protein 4 concentrations and gestational diabetes mellitus and risk of developing metabolic syndrome after pregnancy [J]. Reprod Sci,2010,17(2):196.
4、 陈震宇,李巨. 妊娠肥胖、妊娠糖尿病与脂肪因子的关系研究[J]. Chinese Journal of Woman and Child Health Research,2011,22(2) 200-203. 陈震宇,李巨. 妊娠肥胖、妊娠糖尿病与脂肪因子的关系研究[J]. Chinese Journal of Woman and Child Health Research,2011,22(2) 200-203.
5、 Chan TF,Chen HS, Chen YC,et al. Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus[J]. Reproductive Sciences,2007,14(2)169-174. Chan TF,Chen HS, Chen YC,et al. Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus[J]. Reproductive Sciences,2007,14(2)169-174.
6、 Lewandowski K C, Stojanovic N,Bienkiewica M, et al. Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus: negative correlation with soluble vascular cell adhesion molecule-1 (svcam-1)[J]. Gynecol Endocrinol,2008, 24(6) 300-305. Lewandowski K C, Stojanovic N,Bienkiewica M, et al. Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus: negative correlation with soluble vascular cell adhesion molecule-1 (svcam-1)[J]. Gynecol Endocrinol,2008, 24(6) 300-305.
7、 XueMei Li, Hui Ji,Wang PH, et al. Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus[J]. Annales d' Endocrinologie,2015(76):19-24. XueMei Li, Hui Ji,Wang PH, et al. Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus[J]. Annales d' Endocrinologie,2015(76):19-24.
8、 Van Poppel MN, Zeck W, Ulrich D,et al. Cord blood chemerin: differential effects of gestational diabetes mellitus and maternal obesity [J]. Clin Endocrinol (Oxf),2014,80(1):65-72. Van Poppel MN, Zeck W, Ulrich D,et al. Cord blood chemerin: differential effects of gestational diabetes mellitus and maternal obesity [J]. Clin Endocrinol (Oxf),2014,80(1):65-72.
9、 Barker G, Lim R, Rice GE,et al. Increased chemerin concentrations in fetuses of obese mothers and correlation with maternal insulin sensitivity[J]. J Matern Fetal Neonatal Med,2012,25(11):2274-2280. Barker G, Lim R, Rice GE,et al. Increased chemerin concentrations in fetuses of obese mothers and correlation with maternal insulin sensitivity[J]. J Matern Fetal Neonatal Med,2012,25(11):2274-2280.
10、 El-Mesallamy HO, El-Derany MO, Hamdy NM. Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease[J]. Diabet Med,2011,28(10):1194-1200. El-Mesallamy HO, El-Derany MO, Hamdy NM. Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease[J]. Diabet Med,2011,28(10):1194-1200.
11、 谢幸,苟文丽.《妇产科学》[M]. 8版. 北京:人民卫生出版社,2013:53. 谢幸,苟文丽.《妇产科学》[M]. 8版. 北京:人民卫生出版社,2013:53.
12、 Metzger BE, Gabbe SG, Persson B, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy[J]. Diabetes Care, 2010,33(3):676-682. Metzger BE, Gabbe SG, Persson B, et al. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy[J]. Diabetes Care, 2010,33(3):676-682.
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