目的 探究孕妇血清PAPP-A、IR与妊娠期糖尿病的临床相关性。方法 以我院2013年4月—2014年4月期间收治的160例妊娠期糖尿病孕妇作为观察组,以同期收治的妊娠期正常孕妇作为对照组。对比分析两组孕妇血清PAPP-A含量与IR计算值差异。结果 观察组孕妇血清PAPP-A水平低于对照组,而IR计算值明显高于对照组,差异有统计学意义(P<0.05)。结论 孕妇血清PAPP-A与IR水平与妊娠期糖尿病相关性显著,妊娠期糖尿病患者血清PAPP-A明显降低,而IR则明显增加,可为临床诊断提供参考依据。

Objective To explore the clinical relevance of the pregnant women serum PAPP -a, IR and gestational diabetes. Methods The 160 cases of gestational diabetes mellitus were treated in our hospital from April 2013 to April 2014 as the observation group, and the normal pregnant women were treated as the control group. The differences of serum PAPP-A levels and IR values in the two groups were compared and analyzed. Results The serum PAPP-A level of the observation group was significantly lower than that of the control group, while the IR value was significantly higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion The level of serum PAPP-A and IR in pregnant women is significantly related to the gestational diabetes mellitus. The serum PAPP-A of the patients with gestational diabetes is significantly decreased, while the IR is significantly increased, which can provide reference for clinical diagnosis.