慢性乙型肝炎（CHB）是我国常见的传染病,随着乙型肝炎病毒（HBV）在体内持续活跃复制可进展为肝硬化甚至肝癌,严重威胁患者健康与生命,而高病毒载量CHB患者不仅进展为肝硬化、肝癌的风险和发生母婴垂直传播的风险增加,还存在抗病毒治疗病毒学应答率偏低等特点,目前对高病毒载量CHB患者的管理已引起国内外学者的关注,但尚缺乏系统的研究与阐述。本文将针对上述问题结合国内外相关文献进行综述,期望今后本领域学者对高病毒载量CHB这类特殊患者能有更深入的研究。

Chronic hepatitis B（CHB）is a common infectious disease in China．With the continuous active replication of hepatitis B virus（HBV）in the body,cirrhosis and even liver cancer can progress,seriously threatening the health and life of patients．However,CHB patients with high viral load not only have an increased risk of cirrhosis and liver cancer,mother-to-child vertical transmission,but also with a lower rate of virological response to antiviral therapy．At present,the management of CHB patients with high viral load has attracted the attention of scholars at home and abroad,but there is still a lack of systematic research and elaboration．This paper will focus on the above problems combined with relevant domestic and foreign literature review,hoping that scholars in this field can have more in-depth research on special patients with high viral load CHB in the future．