目的 探讨富血小板血浆联合自体脂肪在大阴唇填充手术中的治疗效果。方法 选择2021年1月—12月在南昌大学第一附属医院整形外科就诊、希望通过自体脂肪移植技术改善大阴唇外观的23例女性患者,年龄23~59 岁,平均年龄（45.23±1.42）岁。依据术前与患者沟通的手术效果,将富血小板血浆和脂肪组织混合并进行注射填充;并分别使用GAIS评价量表、Likert评估量表及 FSFI问卷评估手术效果。结果 每例患者每侧大阴唇的注射量为20~35 mL,术后即刻效果均非常满意,未出现感染、血肿等术后并发症。术后6个月随访,所有患者大阴唇形态符合美学标准;GAIS 评价结果显示,完全改善率达82.61%,明显改善率为13.04%,轻度改善率为 4.35%;阴唇术后效果的满意情况显示,非常满意占86.96%,满意占13.04%,无不满意或非常不满意者;6个月后患者的平均FSFI评分（53.81分）高于术前（31.80分,P<0.001）。结论 富血小板血浆联合自体脂肪注射填充可纠正大阴唇容量缺损,临床疗效良好。

Objective To investigate the therapeutic effect of platelet-rich plasma combined with autologous fat in labia majora filling surgery．Methods From January to December 2021,23 female patients,aged 23-59,with an average age of（45.23±1.42）,were admitted to the Plastic Surgery Department of the First Affiliated Hospital of Nanchang University,hoping to improve the appearance of the labia major through autologous fat transplantation technology．According to the results of preoperative communication with the patient,platelet-rich plasma and adipocytes were mixed and injected to fill the labia majora．GAIS evaluation scale,Likert evaluation scale and FSFI questionnaire were used to evaluate the surgical effect．Results The injection amount of each side of labia majora in all patients was 20~35 mL,the immediate postoperative effect was very satisfactory,and there were no postoperative complications such as infection and hematoma．After 6 months of follow-up,all patients' labia majora morphology met the aesthetic standard．GAIS evaluation results showed that the complete improvement rate was 82.61%,the obvious improvement rate was 13.04%,and the mild improvement rate was 4.35%．The satisfaction of labial postoperative results showed that 86.96% of patients were very satisfied and 13.04% were satisfied,no dissatisfied or very dissatisfied．Six months afterwards,the patients' mean total FSFI score（53.81）was significantly higher than that of preoperation（31.8,P<0.001）．Conclusions Platelet-rich plasma combined with autologous fat injection can correct the labia majora volume defect and obtain satisfactory clinical effect．