目的 探讨沙丁胺醇与M胆碱受体阻断剂应用于支气管哮喘患儿对其症状改善及肺功能的影响。方法 选择我院2018年9月—2019年9月收治的88例支气管哮喘患儿,采用随机数表法分为观察组(n=44)和对照组(n=44)。在对症治疗基础上,对照组给予沙丁胺醇治疗,在对照组基础上,观察组加入M胆碱受体阻断剂(异丙托溴铵气雾剂)治疗。比较两组患儿治疗效果、症状表现、肺功能指标、生活质量及不良反应发生率。结果 与对照组总有效率77.27%(34/44)相比,观察组93.18%(41/44)较高,差异有统计学意义(P＜0.05);治疗7 d后,观察组咳嗽消失时间(5.12±1.88)d、憋喘消失时间(1.88±0.95)d、肺啰音消失时间(5.45±1.21)d均较对照组[(8.03±1.22)d、(3.65±1.04)d、(7.02±1.62)d]短,差异有统计学意义(P＜0.05);治疗7 d后,观察组FVC、FEV₁、PEF水平[(3.38±0.42)、(2.13±0.48)、(435.79±40.75)L/min]均高于对照组[(2.67±0.46)、(1.75±0.43)、(388.94±35.93)L/min],差异有统计学意义(P＜0.05)。治疗7 d后,观察组SGRQ评分(34.11±4.25)分低于对照组(42.52±4.48)分,差异有统计学意义(P＜0.05)。两组不良反应发生率比较[13.64%(6/44),9.09%(4/44)],差异无统计学意义(P＞0.05)。结论 沙丁胺醇与M胆碱受体阻断剂应用于支气管哮喘患儿,可提高其治疗效果,可缩短咳嗽消失、憋喘消失及肺啰音消失时间,改善其肺功能,提高生活质量,降低不良反应发生率,值得临床推广应用。

目的 探讨功能区矢状窦镰旁脑膜瘤患者采用显微镜手术对其手术情况及症状改善的影响。方法 选2015年5月—2018年5月我院择期行手术治疗的40例功能区矢状窦镰旁脑膜瘤患者,参照随机数表法分为对照组(n=20)和研究组(n=20)。对照组采用常规手术治疗,研究组采用显微镜手术,对比两组手术情况及术后症状情况。结果 研究组术中输血量及肿瘤全切除率比对照组均低,住院时间和手术时间均较短,差异有统计学意义(P＜0.05);相较于对照组,研究组术后症状改善发生率较高(95.00% vs 60.00%),症状加重发生率较低(0.00% vs 35.00%),差异有统计学意义(P＜0.05)。结论 显微镜手术可有效减少功能区矢状窦镰旁脑膜瘤患者术中输血量,缩短手术时间,改善临床症状,促进患者术后恢复。

Objective To investigate the effect of microsurgery on the operation and symptom improvement of patients with para-sagittal sinus meningioma in functional area. Methods From May 2015 to May 2018, 40 patients with parasickle meningioma of sagittal sinus in our hospital were randomly divided into two groups: control group (n = 20) and study group (n = 20). The patients in the control group were treated with conventional operation, and the patients in the study group were treated with microscope. Results The volume of blood transfusion and the total resection rate of tumor in the study group were lower than those in the control group, and the duration of hospitalization and operation were shorter than those in the control group. Compared with the control group, the incidence of symptom improvement in the study group was higher (95.00% vs 60.00%), the incidence of symptom exacerbation was lower (0.00% vs 35.00%), the difference was statistically significant (P< 0. 05). Conclusion Microscopy may effectively reduce the amount of blood transfusion, shorten the operation time, improve clinical symptoms and promote postoperative recovery in patients with parasagittal sinus meningioma.