CD117在肺基底样细胞鳞状细胞癌与小细胞肺癌中的鉴别诊断作用

doi:10.3969/j.issn.1000-8535.2018.03.012

摘要/Abstract

摘要： 目的探讨CD117在肺基底样细胞鳞状细胞癌(BSCC)与小细胞肺癌(SCLC)中的鉴别诊断作用。方法免疫组织化学检测CD117在肺BSCC与SCLC中的表达情况,并进行统计学分析,同时文献复习CD117在这两种肿瘤中的表达情况。结果 CD117在SCLC中特异性高表达(阳性率为78%),并且具有高的敏感度、特异度、阳性预测值及阴性预测值(分别为100%、78.2%、68.7%、100%),与文献报道一致(阳性率37%～100%);而在BSCC中未见有CD117的表达,文献未见有CD117在BSCC中表达情况报道。结论 CD117有可能成为鉴别诊断BSCC与SCLC的重要指标之一。但由于本报道例数有限,还需要更大型的研究进一步证明CD117在鉴别诊断二者中的敏感度及特异度。

关键词: CD117, 肺, 基底样细胞鳞状细胞癌, 小细胞肺癌

Abstract: Objective To investigate the role of CD117 in differentiating basaloid squamous cell carcinoma (BSCC) from small cell carcinoma (SCLC) in lung. Methods Immunohistochemistry staining of CD117 and statistic data were analyzed in BSCC and SCLC, and relevant literature were reviewed. Results CD117 was specifically expressed in high level ( positive rate 78%) in SCLC with high sensitivity, specificity, positive predictive value and negative predictive value (respectively 100%、78.2%、68.7%、100%), which was highly consistent with literature reports (positive rate 37%-100%). CD117 was not detected in BSCC in our report and it was the same as in literatures. Conclusion Although our results showed that it was possible that the expression of CD117 would play an important role in differentiating BSCC from SCLC, due to limited cases in number, more studies are needed to elucidated the sensitivity and specificity.

Key words: CD117, Lung, Basaloid squamous cell carcinoma, Small cell lung carcinoma

叶瑶, 陈少红. CD117在肺基底样细胞鳞状细胞癌与小细胞肺癌中的鉴别诊断作用[J]. 广州医药, 2018, 49(3): 44-47.

YE Yao, CHEN Shaohong. The role of CD117 in differentiating basaloid squamous cell carcinoma from small cell carcinoma in lung[J]. Guangzhou Medical Journal, 2018, 49(3): 44-47.

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