继发性肺结核合并肺部真菌感染的临床特点及危险因素分析

doi:10.3969/j.issn.1000-8535.2021.03.017

广州医药 ›› 2021, Vol. 52 ›› Issue (3): 79-83.DOI: 10.3969/j.issn.1000-8535.2021.03.017

继发性肺结核合并肺部真菌感染的临床特点及危险因素分析

王乐玲, 吴碧彤, 董海平, 林庆裕, 胡锦兴

广州市胸科医院结核科 (广州 510095)

收稿日期:2021-01-21 发布日期:2021-11-24
通讯作者: 胡锦兴,E-mail:hujinxing2000@163.com
基金资助:
广州市高水平临床重点专科和培育专科建设项目(穗卫函[2019]155号)

Clinical characteristics and risk factors of secondary pulmonary tuberculosis complicated with pulmonary fungal infection

WANG Leling, WU Bitong, DONG Haiping, LIN Qingyu, HU Jinxing

Department of General Internal Medicine, Guangzhou Chest Hospital, Guangzhou 510095, China

Received:2021-01-21 Published:2021-11-24

摘要/Abstract

摘要： 目的探讨继发性肺结核合并肺部真菌感染的临床特点及相关高危因素。方法收集广州市胸科医院2017年7月—2019年10月收治的继发性肺结核患者资料,病程均大于3个月,分为真菌感染组106例和非真菌感染组100例进行回顾性分析。结果单因素分析结果显示,合并肺部其他疾病、非初治、咯血、空洞、应用广谱抗生素>l周、侵袭性操作存在统计学差异(P<0.05)。Logistic多因素分析结果显示,广谱抗生素使用>l周、侵袭性操作为真菌感染的独立危险因素(P<0.05)。结论对于应用广谱抗生素、进行侵袭性操作的肺结核患者应警惕真菌感染风险,及早预防及诊治。

关键词: 继发性肺结核, 真菌感染, 抗生素应用, 侵袭性操作

Abstract: Objective To investigate the clinical characteristics and related high risk factors of secondary pulmonary tuberculosis complicated with pulmonary fungal infection. Methods Data of patients with secondary tuberculosis admitted to Guangzhou Chest Hospital from July 2017 to October 2019 were collected. All patients with a course of disease longer than 3 months were divided into the fungal infection group (n =106) and the non-fungal infection group (n =100) for retrospective analysis. Results Univariate analysis results showed that there were statistical differences in combined other pulmonary diseases, non-initial treatment, hemoptysis, cavity, application of broad-spectrum antibiotic > for 1 week, and invasive operation (P<0.05). Logistic multivariate analysis showed that >1 week of broad-spectrum antibiotics and invasive procedures were independent risk factors for fungal infection (P<0.05). Conclusion Patients with tuberculosis who are treated with broad-spectrum antibiotics and invasive procedures should be alert to the risk of fungal infection, early prevention and treatment should be undertaken.

Key words: Secondary pulmonary tuberculosis, Fungal infection, Antibiotic application, Invasive operation

王乐玲, 吴碧彤, 董海平, 林庆裕, 胡锦兴. 继发性肺结核合并肺部真菌感染的临床特点及危险因素分析[J]. 广州医药, 2021, 52(3): 79-83.

WANG Leling, WU Bitong, DONG Haiping, LIN Qingyu, HU Jinxing. Clinical characteristics and risk factors of secondary pulmonary tuberculosis complicated with pulmonary fungal infection[J]. Guangzhou Medical Journal, 2021, 52(3): 79-83.

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继发性肺结核合并肺部真菌感染的临床特点及危险因素分析

Clinical characteristics and risk factors of secondary pulmonary tuberculosis complicated with pulmonary fungal infection

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