Napsin A、TTF-1及CK7在恶性胸水中对肺腺癌的诊断价值

doi:10.3969/j.issn.1000-8535.2021.02.015

广州医药 ›› 2021, Vol. 52 ›› Issue (2): 66-69.DOI: 10.3969/j.issn.1000-8535.2021.02.015

Napsin A、TTF-1及CK7在恶性胸水中对肺腺癌的诊断价值

钟玲

广州医科大学附属第二医院病理科(广州 510260)

收稿日期:2020-09-23 出版日期:2021-03-20 发布日期:2021-11-25

Diagnostic value of Napsin A, TTF-1 and CK7 for lung adenocarcinoma in malignant pleural effusion cell block

ZHONG Ling

Department of Pathology,The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260,China

Received:2020-09-23 Online:2021-03-20 Published:2021-11-25

摘要/Abstract

摘要： 目的探讨Napsin A、TTF-1和CK7在恶性胸水细胞蜡块中的表达及对肺腺癌的诊断价值。方法收集已确诊为恶性胸水且行Napsin A、TTF-1及CK7免疫组化标记,并收集患者的血清和胸水CEA,将患者按组织来源分为肺腺癌组和非肺腺癌组,比较Napsin A、TTF-1、CK7、血清CEA和胸水CEA在两组中的表达和浓度并计算它们的诊断价值。结果相对于非肺腺癌组,肺腺癌组患者的Napsin A(83.9% vs 16.1%,P<0.001)、TTF-1(93.5% vs 6.5%,P<0.001)和CK7(98.1% vs 1.9%,P<0.001)阳性表达升高。Napsin A诊断肺腺癌的敏感度为83.9%,特异度为93.9%,TTF-1诊断肺腺癌的敏感度为93.5%,特异度为90.9%;CK7诊断肺腺癌的敏感度为98.1%,特异度为42.4%;明显高于传统肿瘤标志物血清CEA(诊断肺腺癌的敏感度为69.7%,特异度为58.5%)和胸水CEA(诊断肺腺癌的敏感度为69.0%,特异度为66.7%)。结论 Napsin A、TTF-1及CK7对于鉴别肺腺癌恶性胸水及其他肿瘤所致的恶性胸水具有较高的诊断价值。

关键词: 恶性胸水, 肺腺癌, Napsin A, TTF-1, CK7

Abstract: Objective To investigate the expression of Napsin A, TTF-1 and CK7 in paraffin cells block of malignant pleural effusion and their diagnostic value for lung adenocarcinoma. Methods Immunohistochemistry of Napsin A, TTF-1, CK7, serum and pleural fluid CEA were collected from patients with malignant pleural effusion. The patients were divided into lung adenocarcinoma group and non-lung adenocarcinoma groups according to tissue source. The expression of Napsin A, TTF-1, CK7, CEA and the levels of serum and CEA in pleural fluid were compared and their diagnostic value was calculated. Results The positive expression of Napsin A (83.9% vs 16.1%, P<0.001), TTF-1 (93.5% vs 6.5%, P<0.001) and CK7 (98.1% vs 1.9%, P<0.001) in malignant pleural effusion caused by lung adenocarcinoma were higher compared to other tumors. The sensitivity and specificity of Napsin A were 83.9% and 93.9%,the sensitivity and specificity of TTF-1 were 93.5% and 90.9%, and those of CK7 were 98.1% and 42.4%; which were higher than those of serum CEA (69.7% and 58.5%) and pleural fluid CEA (69.0% and 66.7%) respectively. Conclusion Napsin A, TTF-1 and CK7 are of high value in the diagnosis of malignant pleural effusion caused by lung adenocarcinoma from other tumors.

Key words: Malignant pleural effusion, Lung adenocarcinoma, Napsin A, TTF-1, CK7

钟玲. Napsin A、TTF-1及CK7在恶性胸水中对肺腺癌的诊断价值[J]. 广州医药, 2021, 52(2): 66-69.

ZHONG Ling. Diagnostic value of Napsin A, TTF-1 and CK7 for lung adenocarcinoma in malignant pleural effusion cell block[J]. Guangzhou Medical Journal, 2021, 52(2): 66-69.

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Napsin A、TTF-1及CK7在恶性胸水中对肺腺癌的诊断价值

Diagnostic value of Napsin A, TTF-1 and CK7 for lung adenocarcinoma in malignant pleural effusion cell block

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