运动因子对心血管系统保护作用的研究进展

doi:10.20223/j.cnki.1000-8535.2025.07.002

广州医药 ›› 2025, Vol. 56 ›› Issue (7): 870-879.DOI: 10.20223/j.cnki.1000-8535.2025.07.002

运动因子对心血管系统保护作用的研究进展

欧阳嘉富¹, 袁秋菊^1,2, 江芷珊³, 范玉冰⁴, 冯彦翔¹, 孙江鸥⁵, 刘东辉^1,5

1 华南理工大学附属第二医院（广州市第一人民医院）老年医学科（广东广州 510180）
2 广东医科大学（广东湛江 524023）
3 华南理工大学附属第二医院（广州市第一人民医院）临床营养科（广东广州 510180）
4 华南理工大学附属第二医院（广州市第一人民医院）全科医学科（广东广州 510180）
5 紫云苗族布依族自治县人民医院心血管内科（贵州安顺 550800）

收稿日期:2024-11-22 出版日期:2025-07-20 发布日期:2025-08-28
通讯作者: 刘东辉,E-mail：eyliudh@scut.edu.cn
作者简介:刘东辉广州市第一人民医院/华南理工大学附属第二医院老年医学科副主任/老年脏器康复中心主任。北京大学医学博士，主任医师，博士生导师，广州市卫生健康委优秀人才，第八届“羊城好医生”。担任中国健康管理协会生活方式医学分会理事，中国老年医学分会智慧医疗技术与管理分会委员，中国老年保健协会脏器康复专业委员会常务委员，中国心脏联盟广东省心脏康复中心联盟常务委员，中国民族卫生协会卫生健康技术推广专家委员会委员，广东省医学会老年医学分会常务委员，广东省医学会高血压分会委员，广州市医养结合指导中心专家组副主任，广州市医学会心血管病学分会常务委员等。担任Metabolism and Translational Medicine 编委，Health and Metabolism 青年编委。
主要研究方向：糖脂代谢、氧化应激、炎症与动脉粥样硬化和血管衰老等。擅长高血压、血脂紊乱、动脉粥样硬化、冠心病、心力衰竭及代谢性心血管疾病的临床诊治，尤其是各类慢性心血管疾病的“五大处方”心脏康复治疗和抗衰老的非药物治疗。
目前主持国家自然科学基金2项，省级课题5项。主持国家卫生健康技术推广项目“心肺运动试验在老年心血管疾病患者中的应用与推广”1项。以第1作者/通讯作者在Signal Transduct Target Ther等杂志发表SCI论文10余篇。参编中国首部《心血管运动医学指南》等指南2部。主编英文论著Statins - From Lipid-Lowering Benefits to Pleiotropic Effects 1部，参编英文论著Apolipoproteins，Triglycerides and Cholesterol 1部。获得计算机软件著作权1项。获得“福建医学科技奖三等奖”1项，获得“厦门市科学技术进步三等奖”1项。
基金资助:
国家自然科学基金面上项目（32171174）

The protective effects of exerkines on cardiovascular system

OUYANG Jiafu¹, YUAN Qiuju^1,2, JIANG Zhishan³, FAN Yubing⁴, FENG Yanxiang¹, SUN Jiang'ou⁵, LIU Donghui^1,5

1 Department of Geriatric Medicine,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China
2 Guangdong Medical University,Zhanjiang 524023,China
3 Department of Clinical Nutrition,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China
4 Department of General Practice,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China
5 Department of Cardiology,People's Hospital of Ziyun Miao and Buyi Autonomous County,Anshun 550800,China

Received:2024-11-22 Online:2025-07-20 Published:2025-08-28

摘要/Abstract

摘要： 运动可以调节机体代谢,预防和治疗由糖脂代谢紊乱所引发的心血管疾病。运动因子是在运动过程中,由肌肉、脂肪以及肝脏等多个组织合成和分泌的一系列生物活性物质,包括蛋白质和多肽类分子、小分子代谢物以及核酸等。诸多研究证实,运动因子是运动调节机体代谢的重要因素之一,也是机体从运动中获益的关键分子机制。近年来,随着蛋白质组学、代谢组学以及高通量测序等相关技术的飞速发展,越来越多的运动因子被陆续发现和证实。这不仅拓宽了人们对机体从运动中获益相关机制的认知,还激发了人们对运动因子在健康领域应用前景的浓厚兴趣。文章系统地阐述了运动因子对机体心血管系统的影响,旨在揭示运动因子在促进心血管健康以及治疗心血管疾病等方面的积极效用。

关键词: 运动, 运动因子, 心血管疾病, 代谢

Abstract: Exercise can prevent and treat cardiovascular diseases resulting from the metabolic disorders of glucose and lipid．Exerkines are defined as a series of bioactive substances in response to exercise including proteins,peptides,small molecular metabolites and nucleic acids．Multiple tissues can produce exerkines,such as skeletal muscle,adipose tissue,and liver．Many studies indicate that exerkines play essential roles in improving glucose and lipid metabolism,which are crucial to harness the health-related benefits mediated by exercise．In recent years,with the progression of proteomics,metabolomics and high-throughput sequencings,an increasing number of exerkines are discovered．These findings expand the research on beneficial effects of exercise and draw attention to the clinical implications of exerkines．This review aims to explore the influence of exerkines on cardiovascular system and reveal their potential roles in the prevention and treatment of cardiovascular disease．

Key words: exercise, exerkines, cardiovascular disease, metabolism

欧阳嘉富, 袁秋菊, 江芷珊, 范玉冰, 冯彦翔, 孙江鸥, 刘东辉. 运动因子对心血管系统保护作用的研究进展[J]. 广州医药, 2025, 56(7): 870-879.

OUYANG Jiafu, YUAN Qiuju, JIANG Zhishan, FAN Yubing, FENG Yanxiang, SUN Jiang'ou, LIU Donghui. The protective effects of exerkines on cardiovascular system[J]. Guangzhou Medical Journal, 2025, 56(7): 870-879.

参考文献

[1] JIN L,DIAZ-CANESTRO C,WANG Y,et al.Exerkines and cardiometabolic benefits of exercise:From bench to clinic[J].EMBO Mol Med,2024,16(3):432-444.
[2] GARCIA-HERMOSO A,RAMIREZ-VELEZ R,DIEZ J,et al.Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients:A systematic review and meta-analysis of randomized controlled trials[J].J Sport Health Sci,2023,12(2):147-157.
[3] MOTR PACSG,LEAD A,MOTR PACSG.Temporal dynamics of the multi-omic response to endurance exercise training[J].Nature,2024,629(8010):174-183.
[4] SATO S,DYAR K A,TREEBAK J T,et al.Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis[J].Cell Metab,2022,34(2):329-345.e8.
[5] PARR E B,HEILBRONN L K,HAWLEY J A.A time to eat and a time to exercise[J].Exerc Sport Sci Rev,2020,48(1):4-10.
[6] GABRIEL B M,ZIERATH J R.Circadian rhythms and exercise - re-setting the clock in metabolic disease[J].Nat Rev Endocrinol,2019(15):197-206.
[7] CHOW L S,GERSZTEN R E,TAYLOR J M,et al.Exerkines in health,resilience and disease[J].Nat Rev Endocrinol,2022,18(5):273-289.
[8] ROBBINS J M,GERSZTEN R E.Exercise,exerkines,and cardiometabolic health:From individual players to a team sport[J].J Clin Invest,2023,133(11):e168121.
[9] WALZIK D,WENCES CHIRINO T Y,ZIMMER P,et al.Molecular insights of exercise therapy in disease prevention and treatment[J].Signal Transduct Target Ther,2024,9(1):138.
[10] ATHANASIOU N,BOGDANIS G C,MASTORAKOS G.Endocrine responses of the stress system to different types of exercise[J].Rev Endocr Metab Disord,2023,24(2):251-266.
[11] LAURITZEN H P,BRANDAUER J,SCHJERLING P,et al.Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo[J].Diabetes,2013,62(9):3081-3092.
[12] CULLEN T,THOMAS A W,WEBB R,et al.Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise:The effect of exercise intensity and volume[J].Appl Physiol Nutr Metab,2016,41(8):803-808.
[13] NASH D,HUGHES M G,BUTCHER L,et al.IL-6 signaling in acute exercise and chronic training:Potential consequences for health and athletic performance[J].Scand J Med Sci Sports,2023,33(1):4-19.
[14] HOJMAN P,BROLIN C,NORGAARD-CHRISTENSEN N,et al.IL-6 release from muscles during exercise is stimulated by lactate-dependent protease activity[J].Am J Physiol Endocrinol Metab,2019,316(5):E940-E947.
[15] BUSTAMANTE M,FERNANDEZ-VERDEJO R,JAIMOVICH E,et al.Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca(2+)signals and an IL-6 autocrine loop[J].Am J Physiol Endocrinol Metab,2014,306(8):E869-E882.
[16] IKEDA S I,TAMURA Y,KAKEHI S,et al.Exercise-induced increase in IL-6 level enhances GLUT4 expression and insulin sensitivity in mouse skeletal muscle[J].Biochem Biophys Res Commun,2016,473(4):947-952.
[17] CHRISTENSEN R H,LEHRSKOV L L,WEDELL-NEERGAARD A S,et al.Aerobic exercise induces cardiac fat loss and alters cardiac muscle mass through an interleukin-6 receptor-dependent mechanism:Cardiac analysis of a double-blind randomized controlled clinical trial in abdominally obese humans[J].Circulation,2019,140(20):1684-1686.
[18] WEDELL-NEERGAARD A S,LANG LEHRSKOV L,CHRISTENSEN R H,et al.Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling:A randomized controlled trial[J].Cell Metab,2019,29(4):844-855.e3.
[19] MCGINNIS G R,BALLMANN C,PETERS B,et al.Interleukin-6 mediates exercise preconditioning against myocardial ischemia reperfusion injury[J].Am J Physiol Heart Circ Physiol,2015,308(11):H1423-H1433.
[20] SUBBOTINA E,SIERRA A,ZHU Z,et al.Musclin is an activity-stimulated myokine that enhances physical endurance[J].Proc Natl Acad Sci U S A,2015,112(52):16042-16047.
[21] SZAROSZYK M,KATTIH B,MARTIN-GARRIDO A,et al.Skeletal muscle derived Musclin protects the heart during pathological overload[J].Nat Commun,2022,13(1):149.
[22] HARRIS M P,ZENG S,ZHU Z,et al.Myokine musclin is critical for exercise-induced cardiac conditioning[J].Int J Mol Sci,2023,24(7):6525.
[23] JIN L,HAN S,LV X,et al.The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice[J].Nat Commun,2023,14(1):4257.
[24] SANCHEZ Y L,YEPES-CALDERON M,VALBUENA L,et al.Musclin is related to insulin resistance and body composition,but not to body mass index or cardiorespiratory capacity in adults[J].Endocrinol Metab,2021,36(5):1055-1068.
[25] MAAK S,NORHEIM F,DREVON C A,et al.Progress and challenges in the biology of FNDC5 and irisin[J].Endocr Rev,2021,42(4):436-456.
[26] SOUSA R A L,IMPROTA-CARIA A C,SOUZA B S F.Exercise-linked irisin:Consequences on mental and cardiovascular health in type 2 diabetes[J].Int J Mol Sci,2021,22(4):2199.
[27] LIU S,CUI F,NING K,et al.Role of irisin in physiology and pathology[J].Front Endocrinol,2022(13):962968.
[28] BOSTROM P,WU J,JEDRYCHOWSKI M P,et al.A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J].Nature,2012,481(7382):463-468.
[29] OGURI Y,SHINODA K,KIM H,et al.CD81 controls beige fat progenitor cell growth and energy balance via FAK signaling[J].Cell,2020,182(3):563-577.e20.
[30] EL-LEBEDY D H,IBRAHIM A A,ASHMAWY I O.Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus[J].Diabetes Metab Syndr,2018,12(5):643-648.
[31] YIN C,HU W,WANG M,et al.Irisin as a mediator between obesity and vascular inflammation in Chinese children and adolescents[J].Nutr Metab Cardiovasc Dis,2020,30(2):320-329.
[32] LI H,QIN S,LIANG Q,et al.Exercise training enhances myocardial mitophagy and improves cardiac function via irisin/FNDC5-PINK1/Parkin pathway in MI mice[J].Biomedicines,2021,9(6):701.
[33] PAN J A,ZHANG H,LIN H,et al.Irisin ameliorates doxorubicin-induced cardiac perivascular fibrosis through inhibiting endothelial-to-mesenchymal transition by regulating ROS accumulation and autophagy disorder in endothelial cells[J].Redox Biol,2021(46):102120.
[34] INOUE K,FUJIE S,HASEGAWA N,et al.Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity[J].Appl Physiol Nutr Metab,2020,45(7):715-722.
[35] SELDIN M M,PETERSON J M,BYERLY M S,et al.Myonectin(CTRP15),a novel myokine that links skeletal muscle to systemic lipid homeostasis[J].J Biol Chem,2012,287(15):11968-11980.
[36] LI F,LI Y,DUAN Y,et al.Myokines and adipokines:Involvement in the crosstalk between skeletal muscle and adipose tissue[J].Cytokine Growth Factor Rev,2017(33):73-82.
[37] OTAKA N,SHIBATA R,OHASHI K,et al.Myonectin is an exercise-induced myokine that protects the heart from ischemia-reperfusion injury[J].Circ Res,2018,123(12):1326-1338.
[38] LI K,LIAO X,WANG K,et al.Myonectin predicts the development of type 2 diabetes[J].J Clin Endocrinol Metab,2018,103(1):139-147.
[39] DAS D K,GRAHAM Z A,CARDOZO C P.Myokines in skeletal muscle physiology and metabolism:Recent advances and future perspectives[J].Acta Physiol,2020,228(2):e13367.
[40] LEI X,QIU S,YANG G,et al.Adiponectin and metabolic cardiovascular diseases:Therapeutic opportunities and challenges[J].Genes Dis,2023,10(4):1525-1536.
[41] MAEDA N,FUNAHASHI T,MATSUZAWA Y,et al.Adiponectin,a unique adipocyte-derived factor beyond hormones[J].Atherosclerosis,2020(292):1-9.
[42] SCHEJA L,HEEREN J.The endocrine function of adipose tissues in health and cardiometabolic disease[J].Nat Rev Endocrinol,2019,15(9):507-524.
[43] OBATA Y,KITA S,KOYAMA Y,et al.Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release[J].JCI Insight,2018,3(8):99680.
[44] NUMAO S,KATAYAMA Y,HAYASHI Y,et al.Influence of acute aerobic exercise on adiponectin oligomer concentrations in middle-aged abdominally obese men[J].Metabolism,2011,60(2):186-194.
[45] JURIMAE J,PURGE P,JURIMAE T.Adiponectin is altered after maximal exercise in highly trained male rowers[J].Eur J Appl Physiol,2005,93(4):502-505.
[46] CALDWELL J T,JONES K M D,PARK H,et al.Aerobic exercise training reduces cardiac function and coronary flow-induced vasodilation in mice lacking adiponectin[J].Am J Physiol Heart Circ Physiol,2021,321(1):H1-H14.
[47] OKAMOTO Y,FOLCO E J,MINAMI M,et al.Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis[J].Circ Res,2008,102(2):218-225.
[48] ZHANG T,JIANG D,ZHANG X,et al.The role of nonmyocardial cells in the development of diabetic cardiomyopathy and the protective effects of FGF21:a current understanding.Cell Commun Signal.2024,22(1):446.
[49] PONTES L P P,ALVES NAKAKURA F C,NETO N I P,et al.Resistance and aerobic training were effective in activating different markers of the browning process in obesity[J].Int J Mol Sci,2023,25(1):275.
[50] PORFLITT-RODRIGUEZ M,GUZMAN-ARRIAGADA V,SANDOVAL-VALDERRAMA R,et al.Effects of aerobic exercise on fibroblast growth factor 21 in overweight and obesity.A systematic review[J].Metabolism,2022(129):155137.
[51] KIM K H,KIM S H,MIN Y K,et al.Acute exercise induces FGF21 expression in mice and in healthy humans[J].PLoS One,2013,8(5):e63517.
[52] GENG L,LIAO B,JIN L,et al.Exercise alleviates obesity-induced metabolic dysfunction via enhancing FGF21 sensitivity in adipose tissues[J].Cell Rep,2019,26(10):2738-2752.e4.
[53] LOYD C,MAGRISSO I J,HAAS M,et al.Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding[J].J Appl Physiol,2016,121(3):687-698.
[54] JIN L,GENG L,YING L,et al.FGF21-sirtuin 3 axis confers the protective effects of exercise against diabetic cardiomyopathy by governing mitochondrial integrity[J].Circulation,2022,146(20):1537-1557.
[55] BO W,MA Y,FENG L,et al.FGF21 promotes myocardial angiogenesis and mediates the cardioprotective effects of exercise in myocardial infarction mice[J].J Appl Physiol,2023,135(3):696-705.
[56] MA Y,KUANG Y,BO W,et al.Exercise training alleviates cardiac fibrosis through increasing fibroblast growth factor 21 and regulating TGF-β1-Smad2/3-MMP2/9 signaling in mice with myocardial infarction[J].Int J Mol Sci,2021,22(22):12341.
[57] RASMUSSEN P,BRASSARD P,ADSER H,et al.Evidence for a release of brain-derived neurotrophic factor from the brain during exercise[J].Exp Physiol,2009,94(10):1062-1069.
[58] HANG P Z,ZHU H,LI P F,et al.The emerging role of BDNF/TrkB signaling in cardiovascular diseases[J].Life,2021,11(1):70.
[59] SAUCEDO MARQUEZ C M,VANAUDENAERDE B,TROOSTERS T,et al.High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise[J].J Appl Physiol,2015,119(12):1363-1373.
[60] CANTON-MARTINEZ E,RENTERIA I,GARCIA-SUAREZ P C,et al.Concurrent training increases serum brain-derived neurotrophic factor in older adults regardless of the exercise frequency[J].Front Aging Neurosci,2022(14):791698.
[61] MURAWSKA-CIALOWICZ E,WOJNA J,ZUWALA-JAGIELLO J.Crossfit training changes brain-derived neurotrophic factor and irisin levels at rest,after wingate and progressive tests,and improves aerobic capacity and body composition of young physically active men and women[J].J Physiol Pharmacol,2015,66(6):811-821.
[62] LEE H W,AHMAD M,WANG H W,et al.Effects of exercise training on brain-derived neurotrophic factor in skeletal muscle and heart of rats post myocardial infarction[J].Exp Physiol,2017,102(3):314-328.
[63] LEE H W,AHMAD M,WELDRICK J J,et al.Effects of exercise training and TrkB blockade on cardiac function and BDNF-TrkB signaling postmyocardial infarction in rats[J].Am J Physiol Heart Circ Physiol,2018,315(6):H1821-H1834.
[64] ZEMBRON-LACNY A,DZIUBEK W,RYNKIEWICZ M,et al.Peripheral brain-derived neurotrophic factor is related to cardiovascular risk factors in active and inactive elderly men[J].Braz J Med Biol Res,2016,49(7):e5253.
[65] KAESS B M,PREIS S R,LIEB W,et al.Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community[J].J Am Heart Assoc,2015,4(3):e001544.
[66] TAKASHIO S,SUGIYAMA S,YAMAMURO M,et al.Significance of low plasma levels of brain-derived neurotrophic factor in patients with heart failure[J].Am J Cardiol,2015,116(2):243-249.
[67] ROSS M,KARGL C K,FERGUSON R,et al.Exercise-induced skeletal muscle angiogenesis:Impact of age,sex,angiocrines and cellular mediators[J].Eur J Appl Physiol,2023,123(7):1415-1432.
[68] YAZDANI F,SHAHIDI F,KARIMI P.The effect of 8 weeks of high-intensity interval training and moderate-intensity continuous training on cardiac angiogenesis factor in diabetic male rats[J].J Physiol Biochem,2020,76(2):291-299.
[69] MORLAND C,ANDERSSON K A,HAUGEN O P,et al.Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1[J].Nat Commun,2017(8):15557.
[70] HANSEN A H,NIELSEN J J,SALTIN B,et al.Exercise training normalizes skeletal muscle vascular endothelial growth factor levels in patients with essential hypertension[J].J Hypertens,2010,28(6):1176-1185.
[71] WU G,RANA J S,WYKRZYKOWSKA J,et al.Exercise-induced expression of VEGF and salvation of myocardium in the early stage of myocardial infarction[J].Am J Physiol Heart Circ Physiol,2009,296(2):H389-H395.
[72] LIU Y,WANG Y,NI Y,et al.Gut microbiome fermentation determines the efficacy of exercise for diabetes prevention[J].Cell Metab,2020,31(1):77-91.e5.
[73] ZHOU Q,DENG J,PAN X,et al.Gut microbiome mediates the protective effects of exercise after myocardial infarction[J].Microbiome,2022,10(1):82.
[74] MA Y,LIU H,WANG Y,et al.Roles of physical exercise-induced miR-126 in cardiovascular health of type 2 diabetes[J].Diabetol Metab Syndr,2022,14(1):169.
[75] PINCKARD K M,SHETTIGAR V K,WRIGHT K R,et al.A novel endocrine role for the BAT-released lipokine 12,13-diHOME to mediate cardiac function[J].Circulation,2021,143(2):145-159.
[76] TAKAHASHI H,ALVES C R R,STANFORD K I,et al.TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism[J].Nat Metab,2019,1(2):291-303.

运动因子对心血管系统保护作用的研究进展

The protective effects of exerkines on cardiovascular system

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