Wnt/β-catenin信号通路在心肌纤维化中的作用研究进展

doi:10.3969/j.issn.1000-8535.2024.01.015

广州医药 ›› 2024, Vol. 55 ›› Issue (1): 85-90.DOI: 10.3969/j.issn.1000-8535.2024.01.015

Wnt/β-catenin信号通路在心肌纤维化中的作用研究进展

高雅婷¹, 邱对鑫¹, 高磊², 石开虎¹

1 南京中医药大学附属中西医结合医院（江苏南京 210028）
2 南京中医药大学,中医学院·中西医结合学院（江苏南京 210023）

收稿日期:2023-08-07 出版日期:2024-01-20 发布日期:2024-01-24
通讯作者: 石开虎,E-mail：jsszxyskh@163.com
基金资助:
国家自然科学基金（82304941）

Research progress on the role of Wnt / β-catenin signaling pathway in myocardial fibrosis

GAO Yating¹, QIU Duixin¹, GAO Lei², SHI Kaihu¹

1 Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine,Nanjing 210028,China
2 School of Chinese Medicine & School of Integrated Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210023,China

Received:2023-08-07 Online:2024-01-20 Published:2024-01-24

摘要/Abstract

摘要： Wnt/β-catenin信号通路是一种在胚胎发育,细胞增殖分化、迁移,干细胞更新等中起关键作用的蛋白质家族。Wnt/β-catenin信号通路的失调常常会导致各种严重的疾病,例如肿瘤、心脏疾病、肺部疾病、肝脏疾病、骨骼疾病、神经疾病等。大量研究表明,Wnt/β-catenin信号通路在心肌纤维化发病机制中起重要作用,本文结合最新研究成果,从心肌纤维化相关疾病的角度对Wnt/β-catenin通路进行综述,为预防心肌纤维化提供新的思路,进一步达到防治心血管疾病的目的。

关键词: Wnt/β-catenin, 心肌纤维化, 心血管疾病

Abstract: The Wnt/β-catenin signaling pathway is a family of proteins that play a key role in embryonic development,cell proliferation and differentiation,migration,stem cell renewal,etc．Dysfunctions of Wnt/β-catenin signaling pathway often lead to various serious diseases,such as tumor,heart,lung,liver,bone and neurological diseases,etc．Numerous studies have shown that the Wnt/β-catenin signaling pathway plays an important role in the pathogenesis of cardiac fibrosis．This article,in combination with the latest research findings,presents a review of the Wnt/β-catenin pathway from the perspective of myocardial fibrosis-related diseases,in order to provide new ideas for preventing myocardial fibrosis and achieving the goal of combating cardiovascular disease．

Key words: Wnt / β-catenin, myocardial fibrosis, cardiovascular disease

高雅婷, 邱对鑫, 高磊, 石开虎. Wnt/β-catenin信号通路在心肌纤维化中的作用研究进展[J]. 广州医药, 2024, 55(1): 85-90.

GAO Yating, QIU Duixin, GAO Lei, SHI Kaihu. Research progress on the role of Wnt / β-catenin signaling pathway in myocardial fibrosis[J]. Guangzhou Medical Journal, 2024, 55(1): 85-90.

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Wnt/β-catenin信号通路在心肌纤维化中的作用研究进展

Research progress on the role of Wnt / β-catenin signaling pathway in myocardial fibrosis

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