戊型肝炎病毒感染诊疗的研究进展

doi:10.20223/j.cnki.1000-8535.2025.06.002

摘要/Abstract

摘要： 戊型肝炎病毒（HEV）是导致急性肝炎的重要病原体,部分HEV感染者可进展为肝衰竭,此外,慢性感染和肝外表现可也在HEV感染者中发生。全球每年感染HEV的患者数达2000万,其中330万例患者有肝炎相关的临床症状,年死亡例数约为4.4万（2015年数据）。在我国,HEV以散发流行为主。近年来由于对其研究的重视,HEV病原学、流行病学、临床诊疗和预防取得较大的进展,文章拟对目前HEV防治热点以及新进展进行总结和分析。

关键词: 戊型肝炎病毒, 病原学, 流行病学, 诊断, 治疗

Abstract: Hepatitis E virus（HEV）is an important pathogen that causes acute hepatitis．Some HEV-infected individuals may progress to liver failure．In addition,chronic infection（including liver fibrosis and cirrhosis）and extrahepatic manifestations can also occur in HEV infection．Worldwide,there are 20 million cases of HEV infection each year,with 3.3 million cases presenting clinical symptoms related to hepatitis,and an annual death toll of approximately 44,000（data from 2015）．In China,HEV mainly present as sporadic outbreaks．In recent years,there has been significant progress in the pathogenesis,epidemiology,clinical diagnosis and treatment,and prevention of HEV．This review aims to summarize and analyze the current hotspots and new developments in the prevention and treatment of HEV．

Key words: hepatitis E virus, pathogenesis, epidemiology, diagnosis, treatment

邓浩辉, 邱玖香, 刘惠媛. 戊型肝炎病毒感染诊疗的研究进展[J]. 广州医药, 2025, 56(6): 735-745.

DENG Haohui, QIU Jiuxiang, LIU Huiyuan. Research progress on diagnosis and treatment of hepatitis E virus infection[J]. Guangzhou Medical Journal, 2025, 56(6): 735-745.

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