全身免疫炎症指数与心血管疾病相关研究进展

doi:10.3969/j.issn.1000-8535.2024.09.003

摘要/Abstract

摘要： 慢性炎症是心血管疾病的常见发病机制,它主要通过损伤内皮细胞、氧化应激和刺激血栓形成影响疾病发展。全身免疫炎症指数（SII）作为一种新型炎症指标,最早用于肿瘤患者的预后评估,现已在多学科领域广泛使用,它由中性粒细胞、血小板、淋巴细胞计算得到,更加全面地反映机体炎症状态。SII已经在多项研究中被证实具有良好的预测价值,该文对SII的优势和在心血管疾病的临床研究进展进行综述,为研究的进一步开展提供参考。

关键词: 全身免疫炎症指数, 心血管疾病, 临床研究

Abstract: Chronic inflammation is a common pathogenesis of cardiovascular disease,which mainly affects disease progression by damaging endothelial cells,oxidative stress and stimulating thrombosis．As a new type of inflammatory index,the systemic immune inflammatory index（SII）was first used to evaluate the prognosis of cancer patients,and has been widely used in multidisciplinary fields．SII has been confirmed to have good predictive value in a number of studies,and this article reviews the advantages of SII and the progress of clinical research in cardiovascular diseases,so as to provide reference for further research development．

Key words: systemic immune-inflammation index（SII）, cardiovascular diseases, clinical research

朱怡怡, 杨婵, 王振兴. 全身免疫炎症指数与心血管疾病相关研究进展[J]. 广州医药, 2024, 55(9): 985-990.

ZHU Yiyi, YANG Chan, WANG Zhenxing. Research progress on systemic immune inflammation index and cardiovascular disease[J]. Guangzhou Medical Journal, 2024, 55(9): 985-990.

参考文献

[1] HU B,YANG X R,XU Y,et al.Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma[J].Clin Cancer Res,2014,20(23):6212-6622.
[2] TANG Y,ZENG X,FENG Y,et al.Association of systemic immune-inflammation index with short-term mortality of congestive heart failure:A retrospective cohort study[J].Front Cardiovasc Med,2021(8):753133.
[3] ZHENG H,YIN Z,LUO X,et al. Associations between systemic immunity-inflammation index and heart failure:Evidence from the NHANES1999-2018[J].Int J Cardiol,2023(395):131400.
[4] BALCI K,ERBAY I,FEMIRKAN B,et al.The association of hemodynamic markers of right ventricular dysfunction with SII index and clinical outcomes in reduced ejection fraction heart failure[J].Medicine(Baltimore),2023,102(34):e34809.
[5] SWIRSKI F K,NAHRENDORF M.Leukocyte behavior in atherosclerosis,myocardial infarction,and heart failure[J].Science,2013,339(6116):161-166.
[6] CHARACH G,GROSSKOPF I,ROTH A,et al.Usefulness of total lymphocyte count as predictor of outcome in patients with chronic heart failure[J].Am J Cardiol,2011,107(9):1353-1356.
[7] VADUGANATHAN M,AMBROSY A P,GREENE S J,et al.EVEREST trial investigators.Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction:Insights from the EVEREST trial[J].Circ Heart Fail,2012,5(6):750-758.
[8] YE G L,CHEN Q,CHEN X,et al.The prognostic role of platelet-to-lymphocyte ratio in patients with acute heart failure:A cohort study[J].Sci Rep,2019,9(1):10639.
[9] DZIEDZIC E A,GĄSIOR J S,TUZIMEK A,et al.Investigation of the associations of novel inflammatory biomarkers-systemic inflammatory index(SII)and systemic inflammatory response index(SIRI)-with the severity of coronary artery disease and acute coronary syndrome occurrence[J].Int J Mol Sci,2022,23(17):9553.
[10] KELESOGLU S,YILMAZ Y,ELCIK D,et al.Systemic immune inflammation index:A novel predictor for coronary collateral circulation[J].Perfusion,2022,37(6):605-612.
[11] URBANOWICZ T,MICHALAK M,AL-LMAM A,et al.The significance of systemic immune-inflammatory index for mortality prediction in diabetic patients treated with off-pump coronary artery bypass surgery[J].Diagnostics(Basel),2022,12(3):634.
[12] DZIEDZIC E A,GĄSIOR J S,TUZIMEK A,et al.The association between serum vitamin D concentration and new inflammatory biomarkers-systemic inflammatory index(SII)and systemic inflammatory response(SIRI)-In patients with ischemic heart disease[J].Nutrients,2022,14(19):4212.
[13] LI Q,MA X,SHAO Q,et al.Prognostic impact of multiple lymphocyte-based inflammatory indices in acute coronary syndrome patients[J].Front Cardiovasc Med,2022(9):811790.
[14] ERTEM A G,OZEN Y,YUKSEKKAYA B,et al.Association of the Novel Inflammatory Marker Systemic Immune-Inflammation index and Contrast-Induced Nephropathy in Patients Undergoing Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis[J].Angiology,2022,73(5):422-430.
[15] SELCUK M,CINAR T,SAYLIK F,et al.Predictive value of systemic immune inflammation index for postoperative atrial fibrillation in patients undergoing isolated coronary artery bypass grafting[J].Medeni Med J,2021,36(4):318-324.
[16] LIN K B,FAN F H,CAI M Q,et al.Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke[J].Eur J Med Res,2022,27(1):106.
[17] YANG X,ZHAO S,WANG S,et al.Systemic inflammation indicators and risk of incident arrhythmias in 478,524 individuals:evidence from the UK Biobank cohort[J].BMC Med,2023,21(1):76.
[18] DOLU A K,AKÇAY F A,ATALAY M,et al.Systemic immune-inflammation index as a predictor of left atrial thrombosis in nonvalvular atrial fibrillation[J].J Tehran Heart Cent,2023,18(2):87-93.
[19] XIANG J,HE L,LI D,et al.Value of the systemic immune-inflammation index in predicting poor postoperative outcomes and the short-term prognosis of heart valve diseases:A retrospective cohort study[J].BMJ Open,2022,12(10):e064171.
[20] YOON J,JUNG J,AHN Y,et al.Systemic immune-inflammation index predicted short-term outcomes in patients undergoing isolated tricuspid valve surgery[J].J Clin Med,2021,10(18):4147.
[21] TOSU A R,KALYONCUOGLU M,BITER H I,et al.Prognostic value of systemic immune-inflammation index for major adverse cardiac events and mortality in severe aortic stenosis patients after TAVI[J].Medicina(Kaunas),2021,57(6):588.
[22] ERDOĞAN M,ÖZTÜRK S,KARDESLER B,et al.The relationship between calcific severe aortic stenosis and systemic immune-inflammation index[J].Echocardiography,2021,38(5):737-744.
[23] KELESOGLU S,ELCIK D,ZEBGIN I,et al.Association of spontaneous echo contrast with Systemic Immune Inflammation Index in patients with mitral stenosis[J].Rev Port Cardiol,2022,41(12):1001-1008.
[24] ZHANG Y,LIU W,YU H,et al.Value of the systemic immune-inflammatory index(SII)in predicting the prognosis of patients with peripartum cardiomyopathy[J].Front Cardiovasc Med,2022(9):811079.
[25] WANG Z,RUAN H,LI L,et al.Assessing the relationship between systemic immune-inflammation index and mortality in patients with hypertrophic cardiomyopathy[J].Ups J Med Sci,2021:126.
[26] AGUS H Z,KAHRAMAN S,ARSLAN C,et al.Systemic immune-inflammation index predicts mortality in infective endocarditis[J].J Saudi Heart Assoc,2020,32(1):58-64.
[27] HU W,SU G,ZHU W, et al.Systematic immune-inflammation index predicts embolic events in infective endocarditis[J].Int Heart J,2022,63(3):510-516.
[28] YARADILMIS R M,GUNEYLIOGLU M M,ÖZTURK B,et al.A novel marker for predicting fulminant myocarditis:Systemic immune-inflammation index[J].Pediatr Cardiol,2023,44(3):647-655.