SII、NLR和PLR 水平对急性缺血性卒中伴发卵圆孔未闭的诊断价值

doi:10.3969/j.issn.1000-8535.2023.09.005

广州医药 ›› 2023, Vol. 54 ›› Issue (9): 28-33.DOI: 10.3969/j.issn.1000-8535.2023.09.005

SII、NLR和PLR 水平对急性缺血性卒中伴发卵圆孔未闭的诊断价值

肖丽姣, 温小军

广州市第一人民医院（华南理工大学附属第二医院）神经内科（广东广州 510180）

收稿日期:2023-03-09 出版日期:2023-09-20 发布日期:2023-10-12
通讯作者: 温小军,E-mail:docwenxj@126.com
基金资助:
广东省医学科研基金（A2020281）; 广州市卫健委西医类一般引导项目（20231A011014）

Diagnostic value of SII,NLR and PLR levels in acute ischemic stroke with patent foramen ovale

XIAO Lijiao, WEN Xiaojun

Department of Neurology,Guangzhou First People’s Hospital,the Second Affiliated Hospital of South China University of Techology,Guangzhou 510180,China

Received:2023-03-09 Online:2023-09-20 Published:2023-10-12

摘要/Abstract

摘要： 目的评估全身免疫炎症指数（SII）、中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）在区分急性缺血性卒中（AIS）伴发卵圆孔未闭（PFO）与非伴发PFO患者的价值。方法回顾性分析100例AIS患者的血液和血清指标,计算SII、NLR和PLR,使用Logistic回归及受试者操作特征（ROC）曲线分析3项指标在鉴别AIS伴发PFO与非伴发PFO中的价值。结果伴发PFO的AIS患者SII、NLR、PLR高于非伴发PFO的AIS患者,其中以SII最为明显（P均<0.05）。单因素Logistic回归显示,中性粒细胞计数、淋巴细胞计数、PLR、NLR、SII与AIS伴发PFO有关（P<0.05）。ROC曲线分析结果,SII、NLR、PLR鉴别AIS伴PFO与非伴PFO患者,最佳阈值分别为476.4、1.99、115.3,曲线下面积分别为0.777、0.767、0.708。结论 SII、NLR和PLR可作为鉴别AIS患者是否伴发PFO的生物标志物,具有潜在临床应用价值。

关键词: 缺血性脑卒中, 卵圆孔未闭, 全身免疫炎症指数, 中性粒细胞/淋巴细胞比值, 血小板/淋巴细胞比值

Abstract: Objective To evaluate the value of systemic immune-inflammatory index（SII）,neutrophil/lymphocyte ratio（NLR）and platelet/lymphocyte ratio（PLR）in distinguishing acute ischemic stroke（AIS）patients with patent foramen ovale（PFO）and without PFO．Methods A retrospective analysis of blood and serum indicators in 100 AIS patients was conducted,and SII,NLR and PLR indices were calculated．Logistic regression and ROC curve analyses were performed．Results SII,NLR and PLR were significantly higher in PFO patients than in non-PFO patients,with SII being the most significant．Univariate logistic regression showed that Neu,Lym,PLR,NLR,and SII variables were significantly associated with AIS combined with PFO（P<0.05）．ROC curve analysis revealed that the optimal cut-off values for SII,NLR and PLR in distinguishing AIS patients with PFO from those without PFO were 476.4,1.99 and 115.3,respectively,with area under the curve of 0.777,0.767 and 0.708．Conclusions SII,NLR and PLR can serve as biomarkers for identifying AIS patients with PFO,offering potential clinical application value．

Key words: AIS, PFO, SII, NLR, PLR

肖丽姣, 温小军. SII、NLR和PLR 水平对急性缺血性卒中伴发卵圆孔未闭的诊断价值[J]. 广州医药, 2023, 54(9): 28-33.

XIAO Lijiao, WEN Xiaojun. Diagnostic value of SII,NLR and PLR levels in acute ischemic stroke with patent foramen ovale[J]. Guangzhou Medical Journal, 2023, 54(9): 28-33.

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SII、NLR和PLR 水平对急性缺血性卒中伴发卵圆孔未闭的诊断价值

Diagnostic value of SII,NLR and PLR levels in acute ischemic stroke with patent foramen ovale

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