HER-2联合血清肿瘤标志物检测在胃癌诊断中的临床价值

doi:10.3969/j.issn.1000-8535.2023.07.005

广州医药 ›› 2023, Vol. 54 ›› Issue (7): 30-34.DOI: 10.3969/j.issn.1000-8535.2023.07.005

HER-2联合血清肿瘤标志物检测在胃癌诊断中的临床价值

李玲

荆门市妇幼保健院检验科（荆门 448000）

收稿日期:2022-11-28 出版日期:2023-07-20 发布日期:2023-08-15
通讯作者: 李玲,E-mail：ll1079205272@163.com

The value of HER-2 and tumor marker in the diagnosis of gastric cancer

LI Ling

Clinical laboratory, Jingmen Women and Childrens Health, Jingmen 448000, China

Received:2022-11-28 Online:2023-07-20 Published:2023-08-15

摘要/Abstract

摘要： 目的分析在胃癌诊断中应用人表皮生长因子受体2（HER-2）结合肿瘤标志物检测的意义。方法回顾性选取2019年6月—2021年6月我院收治的100例胃癌患者作为胃癌组,另选同期收治的60例胃良性肿瘤患者作为胃良性肿瘤组。比较HER-2与多项肿瘤标志物检测的诊断效能等。结果胃癌组HER-2、糖类抗原（CA）125、CA72-4及CA19-9浓度与阳性表达率高于胃良性肿瘤组（P<0.05）。对于胃癌诊断,免疫组化指标HER-2检测的敏感度为72.00%,正确率为77.00%;多项肿瘤标志物检测的敏感度为77.00%,正确率为80.00%;二者联合检测的敏感度为89.00%,正确率为90.00%;相较于多项肿瘤标志物与HER-2单一检测,二者联合检验的正确率、敏感度更高（P<0.05）。结论 HER-2结合血清肿瘤标志物检验对胃癌的诊断价值较高。

关键词: 人表皮生长因子受体2, 胃癌, 阳性表达, 肿瘤标志物

Abstract: Objective To analyze the significance of human epidermal growth factor receptor 2（HER-2）combined with tumor marker in the diagnosis of gastric cancer．Methods A total of 100 patients with gastric cancer admitted to our hospital from June 2019 to June 2021 were retrospectively selected as the gastric cancer group, and 60 cases of gastric benign tumor admitted to our hospital during the same period were also selected．The diagnostic efficacy of HER-2 was compared with those of multiple tumor markers．Results The concentration and positive expression rate of HER-2, carbohydrate antigen（CA）125, CA72-4 and CA19-9 in gastric cancer group were higher than those in gastric benign tumor group（P<0.05）．For the diagnosis of gastric cancer, the sensitivity of the immunohistochemical indicator HER-2 detection was 72.00%, and the accuracy rate was 77.00%．The sensitivity and accuracy of detecting multiple tumor markers were 77.00% and 80.00%, respectively．The sensitivity of the combined detection of the two was 89.00%, and the accuracy was 90.00%．Compared to multiple tumor markers and HER-2 single detection, the combined test of the two had a higher accuracy and sensitivity（P<0.05）．Conclusions The detection of HER-2 combined with serum tumor markers has high diagnostic value for gastric cancer．

Key words: human epidermal growth factor receptor 2, gastric cancer, positive expression, tumor marker

李玲. HER-2联合血清肿瘤标志物检测在胃癌诊断中的临床价值[J]. 广州医药, 2023, 54(7): 30-34.

LI Ling. The value of HER-2 and tumor marker in the diagnosis of gastric cancer[J]. Guangzhou Medical Journal, 2023, 54(7): 30-34.

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HER-2联合血清肿瘤标志物检测在胃癌诊断中的临床价值

The value of HER-2 and tumor marker in the diagnosis of gastric cancer

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