血清胃蛋白酶原对胃癌筛查价值的探讨

doi:10.3969/j.issn.1000-8535.2016.01.008

广州医药 ›› 2016, Vol. 47 ›› Issue (1): 24-26.DOI: 10.3969/j.issn.1000-8535.2016.01.008

血清胃蛋白酶原对胃癌筛查价值的探讨

江堤, 苏剑东, 张莉, 刘美红, 乐有林, 廖素环

广东省东莞市中山大学附属东华医院消化内科 (东莞 523000)

收稿日期:2015-08-31 出版日期:2016-01-20 发布日期:2021-11-30
基金资助:
东莞市科技局(201110515046234)

The value of serum pepsinogen for gastric cancer screening

Jiang Di, Su Jiandong, Zhang Li, et al

Department of Gastroenterology of Dongguan Tung Wah Hospital, Dongguan, Guangdong 523000

Received:2015-08-31 Online:2016-01-20 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨血清胃蛋白酶原在胃癌筛查中的价值。方法用ELISA方法对1102名患者血清PG水平进行检测,并行内镜病理组织学检查,采用ROC曲线确定PG筛查胃癌的最佳界定值。结果与对照组、萎缩性胃炎组、胃良性溃疡组相比,早期胃癌组、进展期胃癌组PGI、PGR下降(P＜0.05),进展期胃癌组PGI、PGR较早期胃癌组下降(P＜0.05)。与对照组相比,早期胃癌组、进展期胃癌组、胃良性溃疡组PGII升高(P＜0.05)。PGI及PGR在ROC曲线下面积为0.920和0.831,对胃癌的诊断价值较高。PGI≤71.50 μg/L或PGR≤4.50作为筛查标准时,对胃癌高危人群筛查的灵敏度为83.33%,特异度为82.25%。结论血清PGI、PGR在不同胃部病变中的表达水平不一致,对胃癌的早期筛查和早期诊断具有重要价值。PGI≤71.50 μg/L或PGR≤4.50是东莞地区筛查胃癌较合适的界定值。

关键词: 血清胃蛋白酶原, 胃癌, 筛查, 酶联免疫吸附试验

Abstract: Objective To investigate the value of serum pepsinogen PG detection for screening of gastric cancer. Methods PG was detected by ELISA of 1102 people, gastrointestinal endoscopy and biopsy pathology were also carried on. Using ROC curve to establish the PG screening standard, and verified its' value at high risk population of gastric cancer. Results Compared with control group, atrophic gastritis group and benign gastric ulcer group, serum PGI and PGR in early gastric cancer group and advanced gastric cancer group decreased significantly(P＜0.05). Serum PGI and PGR in advanced gastric cancer group were lower than early gastric cancer group(P＜0.05). Serum PGII in early gastric cancer group, advanced gastric cancer group and benign gastric ulcer group were higher than control group(P＜0.05). The area under ROC curve of PGI and PGII was 0.920 and 0.831 respectively, both of them showed high value for the diagnosis of gastric cancer. Took PGI≤71.50μg/L or PGR≤4.50 as the diagnosis criteria, the sensitivity was 83.33% and specificity was 82.25% at high risk population of gastric cancer. Conclusion Serum PGI and PGR were inconsistent in different gastric disease, which showed high sensitivity and specificity in the screening of gastric cancer,and have important value in early screening and early diagnosis of gastric cancer. PGI≤71.50μg/L or PGR≤4.50 were established as the appropriate standard for PG screening.

Key words: Serum pepsinogen PG, Gastric cancer, Screening, ELASE

江堤, 苏剑东, 张莉, 刘美红, 乐有林, 廖素环. 血清胃蛋白酶原对胃癌筛查价值的探讨[J]. 广州医药, 2016, 47(1): 24-26.

Jiang Di, Su Jiandong, Zhang Li, et al. The value of serum pepsinogen for gastric cancer screening[J]. Guangzhou Medical Journal, 2016, 47(1): 24-26.

参考文献

[1] 郑朝旭, 郑荣涛, 张思维, 等. 中国2010年胃癌发病与死亡分析[J]. 中国肿瘤,2014,23(10)1004-1024.
[2] AJANI JA, BENTREN DJ, BESH S. Gastric cancer, version 2. 2013: featured updates to the NCCN Guidelines[J]. J Natl C ompr Canc Netw, 2013, 11(5):531-546.
[3] ISOBE Y, NASHIMPTO A, AKAZAWA K, et al. Gastric cancer treatment in Japan: 2008 annual report of the JGCA nationwide registry [J]. Gastric Cancer, 2011, 14(4):301-316.
[4] MIKI K, FUJISHIRO M, KODASHIMA S, et al. Long-term results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population[J]. Dig Endosc, 2009, 21(2):78-81.
[5] XIAO-MEI ZHANG, JJA-XIN LI, GUI-YING ZHANG. The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China [J]. BMC Gastroenterology, 2014(14):3.
[6] 陆再英, 钟南山, 谢毅, 等. 内科学[M].7版. 北京:人民卫生出版社, 2012, 400.
[7] 中华消化医学会消化内镜分会,中国抗癌协会肿瘤内镜专业委员会. 中国早期胃癌筛查及内镜诊治共识意见(2014年,长沙)[J].中华消化杂志, 2014, 34(7):433-448.
[8] A ZOALFAGHARI, N ALETAHA, N ROUSHAN,et al. Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population[J]. Med J Islam Repub Iran,2014(28):150.
[9] EUN HYE KIM, HUAPYONG KANG, CHAN HYUK PARK, et al. The optimal serum pepsinogen cut-off value for predicting histologically confirmed atrophic gastritis[J]. Digestive and Liver Disease,2015,47.
[10] 范亚平, 丁春梅, 牛爱军, 等. 血清胃蛋白酶原1、2在胃癌诊断中的价值[J]. 临床检验研究,2013, 34(24): 3349-3350.
[11] NEJADI-KELARIJANI F,ROSHANDEL G, SEMNANI S. Diagnostic Values of Serum Levels of Pepsinogens and Gastrin-17 for Screening Gastritis and Gastric Cancer in a High Risk Area in Northern Iran[J]. Asian Pacific Journal of Cancer Prevention, 2014, 15(17):7433-7436.
[12] LOMBA-VIANA R, DINIS-RIBEIRO M, FONSECA F, et al. Serum pepsinogen testfor early detection of gastric cancer in a European country[J]. Eur JGastroenterol Hepatol, 2012, (24):37- 41.
[13] 付明生, 潘淑贤, 许兰涛, 等. 血清胃蛋白酶原对胃癌的诊断价值[J]. 胃肠病学和肝病学杂志, 2012, 21(5):420-422.
[14] MUKOUBAYASHI C, YANAOKA K, OHATA H, et al. Serum pepsinogen and gastric cancer screening[J]. Intern Med,2007,46(6):261-266.

血清胃蛋白酶原对胃癌筛查价值的探讨

The value of serum pepsinogen for gastric cancer screening

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