不同类型尿结石患者肠道菌群结构与尿酸代谢的相关性研究

doi:10.20223/j.cnki.1000-8535.2025.10.011

摘要/Abstract

摘要： 目的探讨不同类型尿结石患者肠道菌群结构与尿酸代谢的相关性研究。方法随机选取2022年5月—2023年5月广州市第一人民医院泌尿外科住院的尿结石患者60例为研究组,选取同期体检中心健康体检人群30名为对照组,按照结石成分将研究组患者分为尿酸组和非尿酸组,每组各30例,所有入选患者均接受结石样本、尿样本、大便样本、血样本的采集,所有样本经光谱、质谱、基因测序、尿常规及血生化检测,比较入选对象的肠道菌群及血尿生化指标变化。结果尿酸组和非尿酸组患者的血磷（SNK-q=7.970、3.542）、血BUN（SNK-q=5.647、4.756）、血SUA（SNK-q=8.178、3.623）、血SCr（SNK-q=7.300、5.553）、血LPS（SNK-q=13.101、9.705）及24h尿酸（SNK-q=4.462、6.426）水平均高于对照组,具有统计学意义（P<0.05）,尿酸组和非尿酸组患者的血钙水平低于对照组（SNK-q=3.918/3.047,P<0.05）。非尿酸组患者的血磷、血SUA、血LPS均低于尿酸组,均有统计学意义（SNK-q=4.428、4.555、3.397,P<0.05）。尿酸组和非尿酸组患者肠道中双歧杆菌数量低于对照组,差异具有统计学意义（SNK-q=3.754、3.143,P<0.05）。非尿酸组患者肠道中乳酸杆菌数量高于对照组和尿酸组（SNK-q=4.105、3.463,P<0.05）,尿酸组及非尿酸组患者的血尿酸及24 h尿尿酸水平与肠道双歧杆菌数量呈负相关（P<0.05）。结论肠道双歧杆菌数量对结石患者血尿酸代谢及尿结石形成具有相关性。

关键词: 肠道菌群, 尿酸, 代谢, 尿酸结石, 双歧杆菌

Abstract: Objective To explore the relationship of intestinal flora and uric acid metabolism in different urinary stones patients．Methods From May 2022 to May 2023,60 patients with urinary stones patients in Guangzhou First People’s Hospital were selected as the study group,and 30 health check-up people in the same period of the medical examination center were selected as the control group．Study group was divided into the uric acid group and the non-uric acid group,30 cases each group,all patients received stone samples,urine samples,stool samples,blood samples collection,mass spectrometry,gene sequencing,urine routine,blood biochemical detection were performed．Intestinal flora and blood urinary biochemical indicators of the patients were compared．Results The levels of blood phosphorus（SNK-q=7.970,3.542）,blood BUN（SNK-q=5.647,4.756）,blood SUA （SNK-q=8.178,3.623）,blood SCr（SNK-q=7.300, 5.553）,blood LPS（SNK-q=13.101,9.705）,and 24-hour urine uric acid （SNK-q=4.462,6.426）in the uric acid group and the non-uric acid group were all higher than those in the control group,and were statistically significant（P<0.05）．The blood calcium levels of the patients in the uric acid group and the non-uric acid group were lower than those in the control group（SNK-q=3.918/3.047,P<0.05）．The blood phosphorus,blood SUA and blood LPS levels of the non-uric acid group were all lower than those of the uric acid group,and the differences were statistically significant （SNK-q=4.428,4.555,3.397,P<0.05）．The number of bifidobacteria in the intestines of patients in the uric acid group and the non-uric acid group was lower than that of the control group,and the differences were statistically significant（SNK-q=3.754,3.143,P<0.05）．The number of lactobacilli in the intestines of patients in the non-uric acid group was higher than that of the control group and the uric acid group（SNK-q=4.105,3.463,P<0.05）．The levels of blood uric acid and 24-hour urine uric acid in the uric acid group and the non-uric acid group were negatively correlated with the number of Bifidobacterium in the intestines（P<0.05）．Conclusions The number of intestinal bisidobacteria has a significant correlation with the metabolism of blood uric acid and urinary stones in patients with stones．

Key words: intestinal flora, uric acid, metabolism, uric acid stones, Bifidobacterium

谢程国, 张镜伟, 邓业瀚. 不同类型尿结石患者肠道菌群结构与尿酸代谢的相关性研究[J]. 广州医药, 2025, 56(10): 1398-1403.

XIE Chengguo, ZHANG Jingwei, DENG Yehan. Correlation between intestinal flora and uric acid metabolism in different types of urinary stones patients[J]. Guangzhou Medical Journal, 2025, 56(10): 1398-1403.

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