乳果糖联合莫沙必利治疗功能性消化不良的疗效及对肠道菌群的影响

doi:10.3969/j.issn.1000-8535.2023.11.007

广州医药 ›› 2023, Vol. 54 ›› Issue (11): 42-45.DOI: 10.3969/j.issn.1000-8535.2023.11.007

乳果糖联合莫沙必利治疗功能性消化不良的疗效及对肠道菌群的影响

于金玲¹, 张海鹏²

1 天津康复疗养中心药械科（天津 300191）
2 天津康复疗养中心接诊随访科（天津 300191）

收稿日期:2023-03-29 出版日期:2023-11-20 发布日期:2023-12-12

Efficacy of lactulose combined with mosapride in treating functional dyspepsia and its effect on intestinal flora

YU Jinling¹, ZHANG Haipeng²

1 Pharmaceutical Department of Tianjin Rehabilitation and Rehabilitation Center,Tianjin 300191,China;
2 Follow-up Department of Tianjin Rehabilitation Center,Tianjin 300191,China

Received:2023-03-29 Online:2023-11-20 Published:2023-12-12

摘要/Abstract

摘要： 目的探讨功能性消化不良（FD）患者应用乳果糖联合莫沙必利治疗的临床疗效及药物对肠道菌群的影响。方法选取2019年1月—2021年12月来院诊治的180例FD患者作为研究对象,随机分为2组,每组90例,对照组口服莫沙必利片,观察组服用莫沙必利片+乳果糖口服液,4周后观察2组患者治疗后临床症状改善率及肠道菌群数量的情况。结果治疗4周后,观察组的总有效率（86.67%）高于对照组（72.22%）,P<0.05;观察组的乳杆菌菌群数多于对照组,肠球菌、肠杆菌菌群数少于对照组,P<0.05。结论乳果糖联合莫沙必利用于FD患者临床治疗,总有效率高于单用莫沙必利,患者症状获得有效改善,明显改善FD患者肠道菌群水平。

关键词: 功能性消化不良, 乳果糖, 莫沙必利, 肠道菌群

Abstract: Objective To explore the clinical efficacy and effect on intestinal flora of lactulose combined with mosapride in patients with functional dyspepsia（FD）．Methods A total of 180 FD patients admitted to the hospital in January 2019 and December 2021 were selected as the study subjects and randomly divided into two groups,90 cases in each group．The control group took oxapride orally and the observation group took lactulose oral solution additionally．After 4 weeks,the improvement rate of clinical symptoms and the number of intestinal flora of patients were observed．Results After 4 weeks of treatment,the total effective rate of the observation group（86.67%）was obviously higher than that of the control group（76.67%）,P<0.05;the number of Lactobacillus in the observation group was higher than that of the control group,and the numbers of Enterococcus and Enterobacteria were less than that of the control group,P<0.05．Conclusions The total effective rate of lactulose combined with mosalabin for FD patients is higher than that of mossalapride alone．The symptoms are effectively improved,and the intestinal flora level of FD patients is significantly improved．

Key words: functional dyspepsia, lactulose, mosapride, intestinal flora

于金玲, 张海鹏. 乳果糖联合莫沙必利治疗功能性消化不良的疗效及对肠道菌群的影响[J]. 广州医药, 2023, 54(11): 42-45.

YU Jinling, ZHANG Haipeng. Efficacy of lactulose combined with mosapride in treating functional dyspepsia and its effect on intestinal flora[J]. Guangzhou Medical Journal, 2023, 54(11): 42-45.

参考文献

[1] 李军祥,陈誩,李岩.功能性消化不良中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2017,25(12):889-894.
[2] 中华医学会消化病学分会胃肠动力学组,中华医学会消化病学分会胃肠功能性疾病协作组.中国功能性消化不良专家共识意见(2015年,上海)[J].中华消化杂志,2016,36(4):217-229.
[3] CHIARIONI G,PESCE M,FANTIN A,et al.Complementary and alternative treatment in functional dyspepsia[J].United European Gastroenterol J,2018,6(1):5-12.
[4] 黄博,崔德军,任映,等.马来酸曲美布汀与多潘立酮治疗老年功能性消化不良的疗效比较[J].中国老年学杂志,2017,37(13):3278-3279.
[5] 郑文秀. 茯苓饮联合莫沙必利治疗脾虚气滞证功能性消化不良的临床观察[D].滨州:滨州医学院,2020.
[6] 谷静. 促动力药治疗功能性消化不良的临床研究[D].重庆:重庆医科大学,2017.
[7] 张睿凯. 温胆汤加减治疗脾虚湿热型胃痞病的临床观察[D].广州:广州中医药大学,2017.
[8] 李文刚,周立君,吴冬寒,等.莫沙必利对功能性消化不良及近端胃舒张和胃排空功能的疗效研究[J].重庆医学,2015,44(2):148-150.
[9] LAM C Y,PALSSON O S,WHITEHEAD W E,et al.Rome IV functional gastrointestinal disorders and health impairment in subjects with hypermobility spectrum disorders or hypermobile ehlers-danlos syndrome[J].Clin Gastroenterol Hepatol,2021,19(2):277-287.e3.
[10] FUTAGAMI S,ITOH T,SAKAMOTO C.Systematic review with meta-analysis:post-infectious functional dyspepsia[J].Aliment Pharmacol Ther,2015,41(2):177-188.
[11] 黄建光. 莫沙必利与多潘立酮治疗功能性消化不良的效果对比分析[J].北方药学,2022,19(6):171-173.
[12] 李娟娟,王凤云,唐旭东,等.肠道菌群失调与功能性消化不良的相关性研究[J].中国中西医结合消化杂志,2019,27(1):77-81.
[13] BARBARA G,FEINLE-BISSET C,GHOSHAL U C,et al.The intestinal microenvironment and functional gastrointestinal disorders[J].Gastroenterology,2016,S0016-5085(16)00219-5.
[14] VANHEEL H,VICARIO M,VANUYTSEL T,et al.Impaired duodenal mucosal integrity and low grade inflammation in functional dyspepsia[J].Gut,2014,63(2):262-271.
[15] 梁子兴,张文丽,钟如玉.枯草杆菌二联活菌联合乳果糖治疗儿童功能性便秘近远期疗效观察[J].齐齐哈尔医学院学报,2019,40(2):176-177.
[16] 李秀锋. 乳果糖与双歧杆菌四联活菌治疗老年人功能性便秘的效果评价[J].中国药物与临床,2019,19(8):1294-1295.
[17] LEE-ROBICHAUD H,THOMAS K,MORGAN J,et al.Lactulose versus polyethylene glycol for chronic constipation[J].Cochrane Database Syst Rev,2010(7):CD007570.
[18] 郝丹丹,刘楠,王飞娟.疏肝和胃方结合莫沙必利片治疗功能性消化不良伴焦虑及抑郁状态的临床研究[J].中国中西医结合消化杂志,2022,30(2):113-116.
[19] 李梅英,武磊,董卫青.乳果糖联合莫沙必利治疗老年慢性功能性便秘的疗效及安全性[J].中国中西医结合消化杂志,2022,30(4):299-302.
[20] 钟景页,程双平,姚欣,等.枸橼酸莫沙必利联合乳果糖治疗老年难治性功能性便秘临床效果观察[J].临床误诊误治,2018,31(11):30-33.

乳果糖联合莫沙必利治疗功能性消化不良的疗效及对肠道菌群的影响

Efficacy of lactulose combined with mosapride in treating functional dyspepsia and its effect on intestinal flora

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 6

编辑推荐

Metrics

本文评价

[1]	刘嘉月, 王彬. 基于浊毒理论探讨代谢综合征病机及治疗[J]. 广州医药, 2023, 54(10): 106-111.
[2]	杨秀芳, 简伟华, 丁俊彩, 陈康, 施尚文. 肠道微生态-LPS-TLR4通路与新生儿坏死性小肠结肠炎炎症损伤的研究[J]. 广州医药, 2022, 53(3): 49-52.
[3]	潘燕珊, 胡锦兴, 王维勇. 强化期抗结核治疗对肺结核患者肠道菌群的影响[J]. 广州医药, 2022, 53(1): 70-75.
[4]	罗梅娟, 胡家奇, 魏颖, 欧巧群, 王丽娜, 张又祥. 低出生体重早产儿应用抗生素后的肠道菌群动态变化[J]. 广州医药, 2021, 52(3): 61-67.
[5]	黄耀星, 严清青, 苏伟, 何梓健, 罗键雄, 李伟冬, 赵寒冰, 贾林. 血必净注射液对ANP大鼠肠道菌群及肠黏膜屏障功能的影响[J]. 广州医药, 2020, 51(3): 14-20.
[6]	唐梁, 向琪, 李世林, 翁维维, 王丽娜. 捏脊联合中药外洗对儿童功能性消化不良的影响[J]. 广州医药, 2015, 46(5): 58-60.