纤维支气管镜肺灌洗治疗重症肺部感染患者的临床疗效

doi:10.3969/j.issn.1000-8535.2018.04.013

广州医药 ›› 2018, Vol. 49 ›› Issue (4): 51-54.DOI: 10.3969/j.issn.1000-8535.2018.04.013

纤维支气管镜肺灌洗治疗重症肺部感染患者的临床疗效

赖伟坤, 李文礼, 潘伟胜

广东省兴宁市人民医院呼吸内科(兴宁 514500)

收稿日期:2018-03-10 出版日期:2018-07-20 发布日期:2021-11-29
通讯作者: 李文礼,E-mail:442778085@qq.com

Clinical effect of bronchoalveolar lavage on patients with severe pulmonary infection

LAI WeiKun, LI Wenli, PAN Weisheng

Department of Internal Medicine, Xingning People's Hospital, Xingning 514500, China

Received:2018-03-10 Online:2018-07-20 Published:2021-11-29

摘要/Abstract

摘要： 目的对比纤维支气管镜肺灌洗治疗和常规治疗重症肺部感染患者的临床疗效。方法将2015年5月—2017年4月间在我院接受治疗的92例重症肺部感染患者作为研究对象,按照随机数字表分为实验组(n=46)和对照组(n=46),其中对照组采用常规对症治疗,实验组加以实施纤维支气管镜肺灌洗治,治疗后,纤支镜气道灌洗检测两组患者的血气分析指标变化,采用ELISA测定血清炎症因子含量,及放射免疫法测定血清应激激素含量。结果经比较,实验组患者治疗后的PaO₂、SaO₂、PaCO₂高于对照组患者(P<0.05);实验组患者的血清炎症因子hs-CRP、IL-6、IL-8水平低于对照组患者(P<0.05);此外,实验组患者的Ang-II、NE、Cor含量低于对照组患者(P<0.05)。结论纤支镜气道灌洗可有助于改善重症肺部感染患者的肺通气功能,降低全身炎症应激程度,促进疾病康复。

关键词: 纤维支气管镜灌洗, 重症肺部感染, 临床疗效, 炎症水平

Abstract: Objective To compare the clinical efficacy of bronchoalveolar lavage and conventional treatment in patients with severe pulmonary infection. Methods 92 patients with severe pulmonary infection treated in our hospital from May 2015 to April 2017 were selected as research objects. They were randomly divided into experimental group (n=46) and control group (n=46). The control group was treated with conventional symptomatic treatment, The experimental group implemented bronchoscopy lung lavage treatment. After treatment, blood gas bronchoscopic airway lavage in two groups were detected with analysis indexes. Serum inflammatory factors were determined by ELISA, and the serum levels of stress hormones were determined by radioimmunoassay. Results After the treatment, the PaO₂, SaO₂ and PaCO₂ in the experimental group were higher than those in the controlgroup(P<0.05). The levels of serum inflammatory factors hs-CRP, IL-6、IL-8 in the experimental group were lower than those in the control group (P<0.05); in addition, the levels of Ang-II, NE and Cor in the experimental group were lower than those in the control group(P<0.05). Conclusion Bronchoscopy airway lavage may help to improve the pulmonary ventilation function of patients with severe pulmonary infection, reduce the degree of systemic inflammatory stress, and promote disease recovery.

Key words: Fiberoptic bronchoscopy lavage, Severe pulmonary infection, Clinical efficacy, Inflammation level

赖伟坤, 李文礼, 潘伟胜. 纤维支气管镜肺灌洗治疗重症肺部感染患者的临床疗效[J]. 广州医药, 2018, 49(4): 51-54.

LAI WeiKun, LI Wenli, PAN Weisheng. Clinical effect of bronchoalveolar lavage on patients with severe pulmonary infection[J]. Guangzhou Medical Journal, 2018, 49(4): 51-54.

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纤维支气管镜肺灌洗治疗重症肺部感染患者的临床疗效

Clinical effect of bronchoalveolar lavage on patients with severe pulmonary infection

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