腹膜透析患者高尿酸血症的影响因素及相关性分析

doi:10.3969/j.issn.1000-8535.2017.05.010

广州医药 ›› 2017, Vol. 48 ›› Issue (5): 39-41.DOI: 10.3969/j.issn.1000-8535.2017.05.010

腹膜透析患者高尿酸血症的影响因素及相关性分析

杨荟, 曾玉纯, 汤颖, 付莎, 梁佩芬, 宛霞, 吕军, 李劲高, 张黎黎, 陈俊哲, 刘擘, 李小梅, 杨素琼, 徐安平

中山大学孙逸仙纪念医院肾内科(广州 510120)

收稿日期:2017-07-14 发布日期:2021-12-01
通讯作者: 徐安平,E-mail:anpxu@163.com
基金资助:
国家自然科学基金面上项目(81670641);广东省公益研究与能力建设专项资金项目(社会发展领域)(2014A020212062)

Influence factors for hyperuricemia in peritoneal dialysis patients and their correlation

YANG Hui, ZENG Yuchun, TANG Ying, FU Sha, LIANG Peifen, WAN Xia, LV Jun, LI Jingao, ZHANG Lili, CHEN Junzhe, LIU Bo, LI Xiaomei, YANG Suqiong, XU Anping

Department of Nephrology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

Received:2017-07-14 Published:2021-12-01

摘要/Abstract

摘要： 目的探讨维持性腹膜透析患者高尿酸血症的临床特点及相关影响因素。方法收集152名腹膜透析患者,根据血尿酸情况将患者分为高尿酸血症组和正常血尿酸组,分析其临床资料。结果高尿酸血症112例(73.7%)。高尿酸血症组的血钾、高血压史、血尿素氮、血清肌酐、血磷、iPTH、甘油三脂水平均较正常尿酸组升高(P均＜0.05);而年龄、血钠、血红蛋白、血白蛋白、前白蛋白、血钙、血清铁、总蛋白、hsCRP、空腹血糖、血总胆固醇、血高密度脂蛋白胆固醇、血低密度脂蛋白胆固醇、KT/V、PET无统计学差异(P均＞0.05)。血尿酸水平与血钾、血尿素氮、血磷呈正相关(P＜0.05)。结论腹膜透析患者高尿酸血症发生率高,血尿酸与血钾、血尿素氮、血磷密切相关,及时纠正高尿酸血症可以改善预后。

关键词: 腹膜透析, 血尿酸, 影响因素, 相关性

Abstract: Objective To investigate the clinical characteristics and its related influence factors of hyperuricemia in peritoneal dialysis patients. Methods A total of 152 peritoneal dialysis patients were enrolled. Patients were classified into hyperuricemia and normal serum uric acid (SUA)groups. Factors associated with hyperuricemia were analyzed. Results Hyperuricemia occurred in 112 cases(73.7%). There were significant differences in serum potassium, the incidence of hypertension, blood urea nitrogen, serum creatinine, serum phosphorus, parathyroid hormone, triglyceride between hyperuricemia and normal SUA groups(P<0.05). There was no significant difference in age, serum sodium, hemoglobin, serum albumin, prealbumin, serum calcium, serum iron, total protein, high sensitive C-reactive protein, serum glucose, total cholesterol, high density lipoproteins, low density lipoproteins, KT/V and PET(P>0.05). SUA levels was positively correlated with serum potassium, blood urea nitrogen and serum phosphorus(P<0.05). Conclusion Hyperuricemia was common in peritoneal dialysis patients, serum potassium levels is correlated with serum potassium, blood urea nitrogen and serum phosphorus. The timely treatment of hyperuricemia may improve the prognosis of peritoneal dialysis patients.

Key words: Peritoneal dialysis, Serum uric acid, Influence factor, Correlation

杨荟, 曾玉纯, 汤颖, 付莎, 梁佩芬, 宛霞, 吕军, 李劲高, 张黎黎, 陈俊哲, 刘擘, 李小梅, 杨素琼, 徐安平. 腹膜透析患者高尿酸血症的影响因素及相关性分析[J]. 广州医药, 2017, 48(5): 39-41.

YANG Hui, ZENG Yuchun, TANG Ying, FU Sha, LIANG Peifen, WAN Xia, LV Jun, LI Jingao, ZHANG Lili, CHEN Junzhe, LIU Bo, LI Xiaomei, YANG Suqiong, XU Anping. Influence factors for hyperuricemia in peritoneal dialysis patients and their correlation[J]. Guangzhou Medical Journal, 2017, 48(5): 39-41.

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腹膜透析患者高尿酸血症的影响因素及相关性分析

Influence factors for hyperuricemia in peritoneal dialysis patients and their correlation

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