血清ADPN、CA125及AMH检测在PCOS中的临床分析

doi:10.3969/j.issn.1000-8535.2023.09.014

广州医药 ›› 2023, Vol. 54 ›› Issue (9): 79-83.DOI: 10.3969/j.issn.1000-8535.2023.09.014

血清ADPN、CA125及AMH检测在PCOS中的临床分析

黄溪豪¹, 冯奕习¹, 李汉秋²

1 广东医科大学医学技术学院（广东东莞 523808）;
2 东莞市中医院检验科（广东东莞 523000）

收稿日期:2023-04-20 出版日期:2023-09-20 发布日期:2023-10-12
通讯作者: 冯奕习,E-mail：myway615@126.com
基金资助:
广东省医学科研基金（C2022126）

Clinical diagnostic value of serum ADPN,CA125 and AMH levels in polycystic ovary syndrome

HUANG Xihao, FENG Yixi, LI Hanqiu

1 College of Medical Technology,Guangdong Medical University,Dongguan 523808,China;
2 Department of Clinical Laboratory,Dongguan Hospital of Traditional Chinese Medicine,Dongguan 523000,China

Received:2023-04-20 Online:2023-09-20 Published:2023-10-12

摘要/Abstract

摘要： 目的探讨血清脂联素（ADPN）、糖类抗原125（CA125）及抗苗勒管激素（AMH）水平检测在多囊卵巢综合征（PCOS）中的临床诊断价值。方法选取2022年1月—2022年9月在东莞市中医院经鹿特丹诊断标准确诊的100例PCOS患者作为PCOS组;PCOS组通过测定患者体质量指数（BMI）是否大于28 kg/m²分为肥胖组和非肥胖组;测定患者的睾酮水平的高低是否大于80 ng/dL分为高雄激素组和非高雄激素组。另选身体健康、年龄与PCOS组相近的100名健康女性作为对照组。分别测定PCOS组和对照组的ADPN、CA125以及AMH,分析血清ADPN、CA125、AMH在PCOS患者中的检测价值。结果 POCS组的BMI、AMH、CA125、睾酮、ADPN与健康组比较差异均有统计学意义（P<0.05）。与对照组比较,PCOS组的BMI、AMH、CA125、睾酮水平升高、ADPN水平降低。PCOS患者的CA125与AMH水平呈正相关（P<0.05）,ADPN与AMH无关（P>0.05）。结论 PCOS 患者血清CA125和AMH水平升高,ADPN水平降低。

关键词: 多囊卵巢综合征, 脂联素, CA125, 抗苗勒管激素

Abstract: Objective To explore the clinical diagnostic value of serum adiponectin（ADPN）,carbohydrate antigen 125（CA125）and anti-Mullerian hormone（AMH）levels in polycystic ovary syndrome（PCOS）．Method A total of 100 patients confirmed with PCOS in Dongguan Traditional Chinese Medicine Hospital from January 2022 to September 2022 were selected as the study subjects．All patients were diagnosed with PCOS according to the 2003 Rotterdam diagnostic criteria,and served as the PCOS group．The PCOS group was divided into obese and non obese group by measuring the patient’s body mass index（BMI）whether was greater than 28 kg/m²．A high androgen group and a non high androgen group were determined by whether the patient’s testosterone level is greater than 80 ng/dL．A hundred healthy women of similar age were selected as the healthy control group．The levels of ADPN,CA125 and AMH were measured in the experimental and control group,and their detection value were analyzed．Results BMI,AMH,CA125,testosterone and ADPN in the POCS group were statistically different compared to the healthy group（P<0.05）．Compared with the PCOS group,the control group showed a significant increase in BMI,AMH,CA125 and testosterone levels,while the PCOS group showed a decrease in ADPN level．There was a positive correlation between CA125 and AMH in patients with PCOS,while there was no correlation between ADPN and AMH．Conclusions The levels of serum CA125 and AMH in PCOS patients significantly increased,while the level of ADPN decreased．The three indicators have good diagnostic value in PCOS and are worth promoting．

Key words: polycystic ovary syndrome, ADPN, CA125, anti-Mullerian hormone

黄溪豪, 冯奕习, 李汉秋. 血清ADPN、CA125及AMH检测在PCOS中的临床分析[J]. 广州医药, 2023, 54(9): 79-83.

HUANG Xihao, FENG Yixi, LI Hanqiu. Clinical diagnostic value of serum ADPN,CA125 and AMH levels in polycystic ovary syndrome[J]. Guangzhou Medical Journal, 2023, 54(9): 79-83.

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血清ADPN、CA125及AMH检测在PCOS中的临床分析

Clinical diagnostic value of serum ADPN,CA125 and AMH levels in polycystic ovary syndrome

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