二甲双胍用于治疗多囊卵巢综合征促排卵的疗效评价

doi:10.3969/j.issn.1000-8535.2021.06.017

广州医药 ›› 2021, Vol. 52 ›› Issue (6): 80-82.DOI: 10.3969/j.issn.1000-8535.2021.06.017

二甲双胍用于治疗多囊卵巢综合征促排卵的疗效评价

莫带弟, 罗笑卿, 赖文瑶

东莞市妇幼保健院生殖中心(东莞 523110)

收稿日期:2021-04-02 出版日期:2021-11-20 发布日期:2021-11-26

Effect of metformin on ovulation induction in polycystic ovarian syndrome

MO Daidi, LUO Xiaoqing, LAI Wenyao

Reproductive Center, Dongguan Maternal and Child Health Hospital,Dongguan 523110,China

Received:2021-04-02 Online:2021-11-20 Published:2021-11-26

摘要/Abstract

摘要： 目的探究二甲双胍在多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者中的促排卵效果。方法选取2019年1月—2020年12月收治的66例PCOS患者进行回顾性分析,以治疗方案为依据进行分组(对照组、观察组),对照组均采用炔雌醇环丙孕酮进行治疗(n=33),观察组则在其基础上联合二甲双胍进行治疗(n=33),对比两组患者的性激素水平[黄体酮生成素(luteinizing hormone,LH)、睾酮(testosterone,T)]、血糖指标[空腹血糖(fasting plasma glucose,FPG)、空腹胰岛素(fasting insulin,FINS)、胰岛素抵抗指数]及促排卵效果。结果观察组在治疗后的LH、T水平均低于对照组(P＜0.05);且观察组在治疗后的FPG、FINS、胰岛素抵抗指数水平均低于对照组(P＜0.05);此外,经过治疗后,观察组患者的排卵率为54.5%,高于对照组的30.3%(P＜0.05)。结论将二甲双胍应用于PCOS患者的治疗方案中,可显著改善其性激素水平及血糖代谢情况,促进排卵率的提升,在PCOS导致的不孕症治疗中具有积极的应用价值。

关键词: 多囊卵巢综合征, 二甲双胍, 促排卵, 性激素

Abstract: Objective To explore the effect of metformin on ovulation induction in patients with polycystic ovarian syndrome (PCOS). Methods A total of 66 cases of PCOS patients from January 2019 to December 2020 were retrospectively analyzed and divided into control group and observation group according to the treatment plan. The control group was treated with ethinylestradiol and cyproterone (n=33), while the observation group was treated with metformin additionally (n=33). The levels of sex hormone (luteinizing hormone,testosterone),the indexes of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistance (HOMA-IR) in the two groups were compared. The effects of ovulation induction were evaluated. Results The hormone levels of the observation group after treatment were lower than those of the control group (P<0.05); and the FPG, FINS and HOMA-IR levels of the observation group after treatment were lower than those of the control group (P<0.05); in addition,the ovulation rate of the observation group was 54.5% after treatment, which was higher than that of the control group (30.3%, P<0.05). Conclusion Metformin in the treatment of PCOS patients could greatly improve their sex hormone levels and blood glucose metabolism, promote ovulation rate, and has application value in the treatment of infertility caused by PCOS.

Key words: polycystic ovarian syndrome, metformin, ovulation induction, sex hormone

莫带弟, 罗笑卿, 赖文瑶. 二甲双胍用于治疗多囊卵巢综合征促排卵的疗效评价[J]. 广州医药, 2021, 52(6): 80-82.

MO Daidi, LUO Xiaoqing, LAI Wenyao. Effect of metformin on ovulation induction in polycystic ovarian syndrome[J]. Guangzhou Medical Journal, 2021, 52(6): 80-82.

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二甲双胍用于治疗多囊卵巢综合征促排卵的疗效评价

Effect of metformin on ovulation induction in polycystic ovarian syndrome

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