联合检测癌胚抗原和β2微球蛋白提高结直肠癌的早期诊断

doi:10.3969/j.issn.1000-8535.2017.03.005

摘要/Abstract

摘要： 目的通过检测结直肠癌患者血清及组织中癌胚抗原(CEA)及β₂微球蛋白(β₂MG)的表达,探讨结合两者在结直肠癌诊断中的作用。方法对30例结直肠癌患者的血清、癌组织和癌旁组织进行CEA及β₂MG检测,设置对照组为行肠镜检查的正常健康体检者30例。分别对比CEA及β₂MG在结直肠癌中的关系,进一步对比CEA及β₂MG两者在结直肠癌在结直肠癌患者中的肿瘤大小、分期、浸润深度及转移的关系。同时对结直肠癌及健康体检者的一般情况如性别、年龄、CEA、β₂MG、血红蛋白及白蛋白进行对比,以进一步了解CEA及β₂MG 在结直肠癌中的重要性。结果 CEA在结直肠癌患者癌组织、癌旁组织及血清中升高的比例为100%、10%、47%;β₂MG在结直肠癌患者癌组织、癌旁组织及血清升高的比例为60%、57%、23%;联合血清中CEA及β₂MG升高的比例为63%;正常对照组中的CEA升高的比例为33%,β₂MG升高的比例为67%;无论CEA还是β₂MG在结直肠癌中均有一定比例的升高,联合两者升高更明显。结论 CEA及β₂MG是恶性肿瘤特别是结直肠癌的重要指标,联合两者的检测提高结直肠癌的早期诊断。

关键词: 癌胚抗原, β₂微球蛋白, 结直肠癌, 早期诊断

Abstract: Objective To detect the expression of carcinoembryonic antigen and β₂ microglobulin in serum and tissue of patients with colorectal cancer, and to explore their roles in the diagnosis of colorectal cancer. Methods 30 patients with colorectal cancer were examined for CEA and β₂MG in serum, cancer and para-cancer tissues, and 30 healthy persons with normal colonoscopy were selected as the control group. The expressions of CEA and β₂MG in serum and tissues were compared, and the relationship between CEA and β₂MG and tumor size, stage, depth of invasion and metastasis were analyzed. Results The increased in proportion of CEA in cancer tissue、para-carcinoma tissue and serum of colorectal cancer was 100%、10%、47%; Similarly, the increased in proportion of β₂MG was 60%、57%、23%;Combined calculation the increased in proportion ofCEA and β₂MG in serum of colorectal cancer was 63%;In the normal control, the increased in proportion of CEA was 33%;The increased in proportion of β₂MG was 67%.Both CEA and β₂MG in colorectal cancer had a certain proportion, the rise of joint both was obviously more. Conclusion CEA and β₂MG are important markers of malignancy, especially colorectal cancer. Combined detection of CEA and β₂MG can improve the early diagnosis of colorectal cancer.

Key words: Carcinoembryonic antigen, β₂ microglobulin, Colorectal cancer, Early diagnosis

梁杏花, 刘佛球, 冯正平. 联合检测癌胚抗原和β₂微球蛋白提高结直肠癌的早期诊断[J]. 广州医药, 2017, 48(3): 21-25.

LIANG Xinghua, LIU Foqiu, FENG Zhengping. Combination of carcinoembryonic antigen and β₂ microglobulin improves early diagnosis of colorectal cancer[J]. Guangzhou Medical Journal, 2017, 48(3): 21-25.

参考文献

[1] 刘志刚,于永铎. 癌胚抗原对大肠癌早期诊断的临床意义[J]. 长春中医药大学学报,2008,24(2):223-224.
[2] 谷俊朝,秦兆寅.血清β₂-微球蛋白测定和大肠癌的关系研究[J]. 肿瘤研究与临床,1996,8(3):145-146.
[3] ERVIN P E,NILSSON K. β₂-microglobulinproduction in vitro by human hematopoietic, mesenchymal and epithelial cells[J]. J Immunol,1974,112(1):137.
[4] 陈胜,李德忠,彭孝纬.组织和血清癌胚抗原含量比值对大肠癌的诊断意义[J]. 胃肠病学和肝病学杂志,2008,17(11):945-949.
[5] HUANG Q F,ZHANG M. Diagnostic value of combined detection of serum CEA CA199 and CA724 in colorectal carcinomas[J]. J Clin Exp Med,2007,6(10):6-7.
[6] 许东哲,金星林,崔海,等.大肠癌血清标志物-癌胚抗原、β₂微球蛋白、铁蛋白何CA242检测及其意义[J]. 延边大学医学学报,1999,22(1):45-48.
[7] 胡志华,朱洪.血清癌胚抗原β₂微球蛋白、血清铁蛋白测定对大肠癌诊断的临床价值[J]. 海南医学院学报,2006,6(4):209-211.
[8] 魏宜胜,彭经,洪楚原,等.结直肠癌术前低蛋白血症的临床意义及预后分析[J]. 实用医学杂志,2012,28(5):778-780.
[9] ISHIZUKA M, NAGATA H, TAKAGI K, et al. Influence of inflammation-based prognostic score on mortality of patients undergoing chemotherapy for far advanced or recurrent unresectable colorectal cancer [J]. Ann Surg, 2009,250(2):268-272.
[10] SUN L C, CHU K S, CHENG S C, et al. Preoperative serum carcinoembryonic antigen, albumin and age are supplementary to UICC staging systems in predicting survival for colorectal cancer patients undergoing surgical treatment [J]. BMC Cancer,2009(9):288.
[11] DUFFY M J. Carcinoembryonic antigen as n marker for colorectal caneer:is it clinically useful[J]. Clin Chem,2001,47(4):624-630.
[12] 鲁瑶,潘瑞芹,原田英也,等.VEGF、MVD和CEA与大肠癌病理学特征及预后相关性的临床研究[J]. 中国实用外科杂志,2005,25(6):362-364.
[13] 庞尔国,池澈,杨智文,等.直肠腔内超声联合血清癌胚抗原检查对直肠癌术前精准分期的意义[J]. 肿瘤研究与临床,2011,23(11):765-767.
[14] 胡杨柳,陈莉,李卫平.腔内超声联合血清癌胚抗原检测对直肠癌分期的诊断[J]. 南昌大学学报(医学版),2012,52(12):67-69.
[15] 臧健,俞林.血清CEA水平与结直肠癌分期及分化程度的关系研究[J]. 山东医药,2013,3(43):84-85.

联合检测癌胚抗原和β₂微球蛋白提高结直肠癌的早期诊断

Combination of carcinoembryonic antigen and β₂ microglobulin improves early diagnosis of colorectal cancer

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 8

编辑推荐

Metrics

本文评价

[1]	郎吉萍, 戴秋月, 吕萍, 郭志刚. 阿司匹林抗结直肠癌的作用机制的生物信息学分析[J]. 广州医药, 2021, 52(6): 23-34.
[2]	王臻, 秦文娟, 翟子敬, 郭雪婷, 王忠, 芦桂林. 三维斑点追踪技术评价结直肠癌化疗患者左心室功能变化的探究[J]. 广州医药, 2021, 52(2): 28-32.
[3]	林群护. 加速康复外科措施在腹腔镜辅助结直肠癌根治术中的应用[J]. 广州医药, 2020, 51(2): 94-98.
[4]	李赟, 李勇, 巩平, 李小英, 李娜. 中性粒细胞与淋巴细胞比值在晚期不可切除结直肠癌患者化疗疗效及预后的意义[J]. 广州医药, 2020, 51(1): 59-65.
[5]	粟琼瑜, 刘洁珍, 蔡琼, 邝玉群. 个体化健康管理对超高龄结直肠癌患者希望水平的影响[J]. 广州医药, 2017, 48(3): 75-77.
[6]	李国文, 李莉珊, 邓庆文, 王斌, 杨志华, 陈金明. 信息协作平台的社区结直肠癌三级防治及干预体系的探索与实践[J]. 广州医药, 2017, 48(1): 45-49.
[7]	李奕铮, 廖蕴华, 潘玲. AKI预警标志物的研究进展[J]. 广州医药, 2016, 47(5): 97-100.
[8]	韦捷, 杜凌, 陈刚, 唐尧. 超声内镜在结直肠癌术前分期及手术方案指导中的应用[J]. 广州医药, 2016, 47(3): 56-57.