AKI预警标志物的研究进展

doi:10.3969/j.issn.1000-8535.2016.05.036

摘要/Abstract

摘要： 急性肾损伤(acute kidney injury,AKI)是由各种因素导致的临床综合征,尽管科学在发展,发病率、死亡率一直居高不下,并且严重影响患者的预后,这主要是由于对肾脏损伤的早期诊断缺乏敏感的、特异性的指标,使得患者错过了最佳的治疗窗口。研究发现在AKI的早期给予干预,能够明显提高患者的预后,达到满意的治疗效果。所以AKI的早期诊断是提高患者的生活质量的关键措施,期间出现了一系列AKI 的早期分子标志物,包括NGAL、IL-18、miRNA、KIM-1、NAG、L-FABP、TIMP-1、IGFBP-7、TFF-3、GST-π、MYL12B等。本文就这些AKI分子标志物进行总结,阐述这些分子标志物在AKI 诊断及预后预测中的价值,以便于及早制定有针对性的 AKI 治疗及护理策略,使早期诊断、早期干预 AKI 成为可能。

李奕铮, 廖蕴华, 潘玲. AKI预警标志物的研究进展[J]. 广州医药, 2016, 47(5): 97-100.

Li Yizheng Liao Yunhua Pan Ling. Research progress of AKI early warning markers[J]. Guangzhou Medical Journal, 2016, 47(5): 97-100.

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