糖化血红蛋白联合超敏C反应蛋白在筛查妊娠期糖尿病的价值

doi:10.3969/j.issn.1000-8535.2015.03.013

广州医药 ›› 2015, Vol. 46 ›› Issue (3): 44-46.DOI: 10.3969/j.issn.1000-8535.2015.03.013

糖化血红蛋白联合超敏C反应蛋白在筛查妊娠期糖尿病的价值

江玉娥, 丘媚妮, 陈海英, 梁小花, 张映霞

嘉应学院医学院附属医院妇产科(广东梅州 514031)

收稿日期:2015-01-07 出版日期:2015-05-20 发布日期:2021-11-30

Combination of HbA1c and hs-CRP examination in screening of gestational diabetes mellitus

Jiang Yue, Qiu Meini, Chen Haiying, et al

Department of Obstetrics and Gynecology, The Affiliated Hospital of Medical College of Jiaying university, Meizhou, 514031, China

Received:2015-01-07 Online:2015-05-20 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨糖化血红蛋白(HbA1c)联合超敏C反应蛋白(hs-CRP)在筛查妊娠期糖尿病(GDM)的临床意义。方法选择2013年9月1日—2014年8月31日在我院妇产科孕期产前检查及分娩的孕妇,根据糖耐量试验(OGTT)、HbA1c和hs-CRP检查,筛查出92例孕妇为GDM组,并随机抽取OGTT正常的健康孕妇90例为NGT组,25例健康孕龄女性为对照组,分析3组FPG、HbA1c、hs-CRP及OGTT结果。结果 GDM组OGTT、HbA1c、hs-CRP高于NGT组和对照组,差异有统计学意义(P<0.01),NGT组与对照组比较,HbA1c、hs-CRP浓度差异无统计学意义(P>0.05),但3组FPG差异无统计学意义(P>0.05),Pearson相关分析显示,HbA1c与hs-CRP呈正相关(r=0.79,P<0.01)。结论 GDM患者HbA1c、hs-CRP水平升高,HbA1c联合hs-CRP可能成为GDM筛查的良好指标。

关键词: 妊娠期糖尿病, 糖化血红蛋白, 超敏C反应蛋白

Abstract: Objective To evaluate the feasibility of combination of glycosylated hemoglobin A1c(HbA1c) and high-sensitivity CRP in screening of gestational diabetes mellitus(GDM). Methods According to glucose tolerance test(OGTT),HbA1c and hs-CRP during 24~28 pregnant weeks,92 women with GDM (GDM group) and 90 normal pregnant women (NGT group) were enrolled in this study with another 25 women of child-bearing age as the control group. The results of FBG, OGTT, HbA1c and hs-CRP among three groups were analyzed. Results OGTT, HbA1c and hs-CRP level in GDM group were higher than that in NGT group and control group (P<0.05), but there were no significant differences of the level of FPG of 3 groups(P>0.05).Compare with NGT group and control group, There were no significant differences of the level of HbA1c and hs-CRP(P>0.05). Pearson correlation analysis showed that HbA1c had significant association with hs-CRP(r=0.79, P<0.01). Conclusion HbA1c and hs-CRP level in GDM group were increased, HbA1c combined with hs-CRP could be of some value in screening of GDM.

Key words: Gestational diabetes mellitus, Glycosylated hemoglobin A1c, High-sensitivity CRP

江玉娥, 丘媚妮, 陈海英, 梁小花, 张映霞. 糖化血红蛋白联合超敏C反应蛋白在筛查妊娠期糖尿病的价值[J]. 广州医药, 2015, 46(3): 44-46.

Jiang Yue, Qiu Meini, Chen Haiying, et al. Combination of HbA1c and hs-CRP examination in screening of gestational diabetes mellitus[J]. Guangzhou Medical Journal, 2015, 46(3): 44-46.

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糖化血红蛋白联合超敏C反应蛋白在筛查妊娠期糖尿病的价值

Combination of HbA1c and hs-CRP examination in screening of gestational diabetes mellitus

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