磁共振酰胺质子转移加权成像在直肠癌中的研究进展

doi:10.3969/j.issn.1000-8535.2023.07.001

摘要/Abstract

摘要： 直肠癌是全球常见的消化道恶性肿瘤之一,准确的影像学评估对直肠癌的诊断和治疗决策至关重要。在各种影像学检查中,磁共振成像已逐渐成为直肠癌不可或缺的检查手段,其中酰胺质子转移加权（APTw）成像是当前直肠癌磁共振成像中的一种极具发展前景的成像技术,其是通过检测病灶中内源性可移动蛋白的酰胺质子与水质子之间的交换,可以更好地在分子水平评估直肠癌病灶的蛋白质浓度、pH值、温度和代谢状态等,在直肠癌中有极大的应用潜能,有助于实现精准医疗。本文主要综述APTw成像在直肠癌中的研究进展、发展前景及尚存在的问题。

关键词: 直肠癌, 酰胺质子加权成像, 诊断, 治疗决策

Abstract: Rectal cancer is one of the most common gastrointestinal malignancies worldwide, and accurate imaging evaluation is essential for the diagnosis and treatment of rectal cancer．In various imaging examinations, magnetic resonance imaging（MRI）has gradually become an indispensable means of rectal cancer, among which amide proton transfer-weighted（APTw）imaging is a promising imaging technology．APTw imaging is to detect the exchange between amide protons of endogenous mobile proteins in lesions and water quality particles, which can better assess the protein concentration, pH, temperature, and metabolic status of rectal cancer at the molecular level．It has great application potential in rectal cancer and contributes to precision medicine．This article mainly reviews the research progress, development prospect and remaining problems of APTw imaging in rectal cancer．

Key words: rectal cancer, amide proton transfer-weighted imaging, diagnosis, decision-making

梁俊君, 陈鑫. 磁共振酰胺质子转移加权成像在直肠癌中的研究进展[J]. 广州医药, 2023, 54(7): 1-9.

LIANG Junjun, CHEN Xin. Magnetic resonance amide proton transfer-weighted imaging in rectal cancer research progress[J]. Guangzhou Medical Journal, 2023, 54(7): 1-9.

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