先天性血管瘤的研究进展

doi:10.20223/j.cnki.1000-8535.2025.08.002

广州医药 ›› 2025, Vol. 56 ›› Issue (8): 1021-1027.DOI: 10.20223/j.cnki.1000-8535.2025.08.002

先天性血管瘤的研究进展

张丽琪¹, 黄晓烨², 斯文越³, 李海波¹, 杨开颖²

1 广州医科大学附属妇女儿童医疗中心,国家儿童区域医疗中心（中南）介入血管瘤科（广东广州 510623）
2 广州医科大学附属妇女儿童医疗中心,国家儿童区域医疗中心（中南）小儿外科（广东广州 510623）
3 广州医科大学附属妇女儿童医疗中心,国家儿童区域医疗中心（中南）科教与数据管理部（广东广州 510623）

收稿日期:2025-02-08 出版日期:2025-08-20 发布日期:2025-09-17
通讯作者: 杨开颖,E-mail：yangkaiying1123@126.com
作者简介:杨开颖医学博士,广州医科大学附属妇女儿童医疗中心博士后。广东省基础与应用基础研究基金项目评审专家、广州市科学技术局科技专家库专家,广州市卫生健康委员会优秀人才。研究方向为皮肤血管肿瘤与脉管畸形的发病机制与临床诊治。目前主持中国博士后科学基金面上项目1项,主持广东省基础与应用基础研究基金自然科学基金面上项目2项,广州市基础与应用基础研究基金青年博士启航项目1项,广州市妇女儿童医疗中心博士科研启动基金1项。此外,担任本科生指导老师,获广州医科大学2025学年度省级大学生创新创业训练计划项目1项、广州医科大学2024—2025学年度校级大学生创新创业训练计划项目1项、广州医科大学2024-2025年度儿科学院大学生科技创新项目1项。担任BMC Pediatrics编委,Precision Clinical Medicine首届青年编委以及Medicine Advances青年编委;同时担任《广州医药》杂志与《实用医学杂志》首届青年编委。以第一或通讯作者（含共同）在Journal of the American Academy of Dermatology、Journal of Translational Medicine等期刊上发表SCI论文10篇,在《中华小儿外科杂志》与《中华皮肤科杂志》等期刊上发表论文10篇。
基金资助:
中国博士后科学基金（2023M730793）; 广东省基础与应用基础研究基金（2023A1515012751,2025A1515012602）; 广州市基础与应用基础研究基金（2024A04J3857）; 广州医科大学附属妇女儿童医疗中心博士启动科研基金（2023BS014）; 广州医科大学儿科学院大学生科技创新项目研究基金（2024ekky002）

Research progress of congenital hemangioma

ZHANG Liqi¹, HUANG Xiaoye², SI Wenyue³, LI Haibo¹, YANG Kaiying²

1 Department of Interventional Therapy and Vascular Anomalies,Guangzhou Women and Children's Medical Center,National Children's Medical Center for South Central Region,Guangzhou Medical University,Guangzhou 510623,China
2 Department of Science Research and Education Management,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou 510623,China
3 Department of Pediatric Surgery,Guangzhou Women and Children's Medical Center,National Children's Medical Center for South Central Region,Guangzhou Medical University,Guangzhou 510623,China

Received:2025-02-08 Online:2025-08-20 Published:2025-09-17

摘要/Abstract

摘要： 先天性血管瘤（CH）是一种较为罕见的良性血管肿瘤,出生前瘤体已经存在,按照出生后瘤体的生长特征可分为4类：不消退型CH、部分消退型CH、快速消退型CH以及迟发性扩张型CH。不同类型的CH其临床特征及治疗方式不同。结合近年CH的研究进展报道,文章对CH的发病机制、临床特征、诊断及治疗着重进行综述,以期更好地为临床诊治提供指导。

关键词: 先天性血管瘤, 发病机制, 临床特征, 治疗, 研究进展

Abstract: Congenital hemangioma（CH）is a relatively rare benign vascular tumor that is present before birth．Based on the growth characteristics of CH after birth,CH can be classified into four types：non-involuting congenital hemangioma,partially involuting congenital hemangioma,rapidly involuting congenital hemangioma,and delayed expanding congenital hemangioma．Different types of CH exhibit distinct clinical features and require different treatment approaches．This review focuses on recent research advances in CH,including its pathogenesis,clinical characteristics,diagnosis,and treatment,aiming to provide better guidance for clinical practice．

Key words: congenital hemangioma, pathogenesis, clinical feature, treatment, research progress

张丽琪, 黄晓烨, 斯文越, 李海波, 杨开颖. 先天性血管瘤的研究进展[J]. 广州医药, 2025, 56(8): 1021-1027.

ZHANG Liqi, HUANG Xiaoye, SI Wenyue, LI Haibo, YANG Kaiying. Research progress of congenital hemangioma[J]. Guangzhou Medical Journal, 2025, 56(8): 1021-1027.

参考文献

[1] BOON L M,ENJOLRAS O,MULLIKEN J B.Congenital hemangioma:Evidence of accelerated involution[J].J Pediatr,1996,128(3):329-335.
[2] NORTH P E,WANER M,JAMES C A,et al.Congenital nonprogressive hemangioma:A distinct clinicopathologic entity unlike infantile hemangioma[J].Arch Dermatol, 2001,137(12):1607-1620.
[3] ENJOLRAS O,MULLIKEN J B,BOON L M,et al.Noninvoluting congenital hemangioma:A rare cutaneous vascular anomaly[J].Plast Reconstr Surg,2001,107(7):1647-1654.
[4] MULLIKEN J B,ENJOLRAS O.Congenital hemangiomas and infantile hemangioma:Missing links[J].J Am Acad Dermatol,2004,50(6):875-882.
[5] NASSERI E,PIRAM M,MCCUAIG C C,et al.Partially involuting congenital hemangiomas:A report of 8 cases and review of the literature[J].J Am Acad Dermatol,2014,70(1):75-79.
[6] WOJCICKI P,WOJCICKA K.Epidemiology,diagnostics and treatment of vascular tumours and malformations[J].Adv Clin Exp Med,2014,23(3):475-484.
[7] KNOPFEL N,WALCHLI R,LUCHSINGER I,et al.Congenital hemangioma exhibiting postnatal growth[J].Pediatr Dermatol,2019,36(4):548-549.
[8] COSSIO M L,DUBOIS J,MCCUAIG C C,et al.Non-involuting congenital hemangiomas(NICH)with postnatal atypical growth:A case series[J].Pediatr Dermatol,2019,36(4):466-470.
[9] HUA C,WANG L,JIN Y,et al.A case series of tardive expansion congenital hemangioma:A variation of noninvoluting congenital hemangioma or a new hemangiomatous entity?[J].J Am Acad Dermatol,2021,84(5):1371-1377.
[10] AYDIN KÖKER S,KÖMÜROĞLU A U,KÖKSOY A Y,et al.Evaluation of GLUT1,IGF-2,VEGF,FGF 1,and angiopoietin 2 in infantile hemangioma[J].Arch Pediatr,2021,28(4):296-300.
[11] PICARD A,BOSCOLO E,KHAN Z A,et al.IGF-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma[J].Pediatr Res,2008,63(3):263-267.
[12] HOLM A,MULLIKEN J B,BISCHOFF J.Infantile hemangioma:The common and enigmatic vascular tumor[J].J Clin Invest,2024,134(8):e172836.
[13] 杨开颖,周江元,龚雪,等.糖酵解通路关键酶在婴幼儿血管瘤中的表达及其作用[J].中华小儿外科杂志,2022,43(11):1007-1012.
[14] AYTURK U M,COUTO J A,HANN S,et al.Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma[J].Am J Hum Genet,2016,98(4):789-795.
[15] FUNK T,LIM Y,KULUNGOWSKI A M,et al.Symptomatic congenital hemangioma and congenital hemangiomatosis associated with a somatic activating mutation in GNA11[J].JAMA Dermatol,2016,152(9):1015.
[16] SMITH R J,METRY D,DEARDORFF M A,et al.Segmental congenital hemangiomas:Three cases of a rare entity[J].Pediatr Dermatol, 2020, 37(3):548-553.
[17] ELBATSH A M O,AMIN-MANSOUR A,HABERKORN A,et al.INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas[J].Nat Cancer,2024,5(3):481-499.
[18] JORDAN M,CARMIGNAC V,SORLIN A,et al.Reverse phenotyping in patients with skin capillary malformations and mosaic GNAQ or GNA11 mutations defines a clinical spectrum with genotype-phenotype correlation[J].J Investig Dermatol,2020,140(5):1106-1110.e2.
[19] LI Y,PAN Y,YANG X,et al.Unveiling the enigmatic role of MYH9 in tumor biology:A comprehensive review[J].Cell Commun Signal,2024,22(1):417.
[20] JANSEN P,MÜLLER H,LODDE G C,et al.GNA14,GNA11,and GNAQ mutations are frequent in benign but not malignant cutaneous vascular tumors[J].Front Genet,2021(12):663272.
[21] LIAU J Y,TSAI J H,LAN J,et al.GNA11 joins GNAQ and GNA14 as a recurrently mutated gene in anastomosing hemangioma[J].Virchows Arch,2020,476(3):475-481.
[22] 陈豪,沈卫民.快速消退型先天性血管瘤的临床病理特征及其发病机制研究进展[J].中国美容整形外科杂志,2024,35(4):242-246.
[23] FOMCHENKO E I,DURAN D,JIN S C,et al.De novo MYH9 mutation in congenital scalp hemangioma[J].Cold Spring Harb Mol Case Stud,2018,4(4):a002998.
[24] 中华医学会整形外科分会血管瘤脉管畸形学组,林晓曦.血管瘤与脉管畸形诊疗指南(2024版)[J].组织工程与重建外科杂志,2024,20(1):1-50.
[25] DELGADO-MIGUEL C,MIGUEL-FERRERO M,DÍAZ M,et al.Multifocal rapidly involuting congenital haemangiomas[J].Acad Dermatol Venereol,2023,37(8):e1025-e1027.
[26] BRAUN V,PREY S,GURIOLI C,et al.Congenital haemangiomas:A single-centre retrospective review[J].BMJ Paediatr Open,2020,4(1):e000816.
[27] HEYMANN W R.Tardive expansion congenital hemangioma:A niche within NICH[J].J Am Acad Dermatol,2021,84(5):1252-1253.
[28] GONG X,HUA C,XIONG P,et al.Conventional ultrasonography and elastography for the diagnosis of congenital and infantile hemangiomas[J].J Dermatol,2020,47(5):527-533.
[29] WAELTI S L,RYPENS F,DAMPHOUSSE A,et al.Ultrasound findings in rapidly involuting congenital hemangioma(RICH)- beware of venous ectasia and venous lakes[J].Pediatr Radiol,2018,48(4):586-593.
[30] CRIVELLI L,MILLISCHER A E,SONIGO P,et al.Contribution of magnetic resonance imaging to the prenatal diagnosis of common congenital vascular anomalies[J].Pediatr Radiol,2021,51(9):1626-1636.
[31] KONANUR A,JIMENEZ J E,KOCHIN M,et al.Non-involuting congenital hemangioma with delayed hypertrophy:A case series[J].Int J Pediatr Otorhinolaryngol,2022(157):111102.
[32] PATEL A,de LEACY R,BERENSTEIN A.Angiographic and clinical features of noninvoluting congenital hemangiomas[J].AJNR Am J Neuroradiol, 2019, 40(5):845-848.
[33] EL ZEIN S,BOCCARA O,SOUPRE V,et al.The histopathology of congenital haemangioma and its clinical correlations:A long-term follow-up study of 55 cases[J].Histopathology,2020,77(2):275-283.
[34] JUAN-CARPENA G,PALAZÓN-CABANES J C,TALLÓN-GUEROLA P,et al.A case series of 18 congenital haemangiomas:Clinical,histological and ultrasound features,and their relationship with complications and atypical behaviour[J].Acta Derm Venereol,2023(103):adv00849.
[35] 梁栋,周博,李娜,等.先天性血管瘤40例临床病理学特征研究[J].中华病理学杂志,2022,51(3):202-206.
[36] QIU T,ZHANG Z,ZHOU J,et al.Clinical features of rapid involuting congenital hemangioma:A prospective study[J].J Am Acad Dermatol,2024,90(4):870-872.
[37] SUN B,CHEN H,WANG L,et al.Can congenital hemangioma cause breast hypoplasia Evidence and literature review[J].Int J Dermatol,2024,63(6):762-764.
[38] KAMATA M,ARAMAKI-HATTORI N,OKABE K,et al.Embolization of congenital hemangioma with severe hemorrhage[J].J Pediatr Surg Case Rep,2021(65):101772.
[39] MARTYANOV A A,TESAKOV I P,KHACHATRYAN L A,et al.Platelet functional abnormalities in pediatric patients with kaposiform hemangioendothelioma/Kasabach-Merritt phenomenon[J].Blood Adv,2023,7(17):4936-4949.
[40] COHEN-CUTLER S,SZYMANSKI L J,BOCKOVEN C,et al.Catastrophic congenital hemangioma with severe coagulopathy leading to fatal cardiac failure:Case report and review[J].Pediatr Dermatol,2021,38(5):1276-1282.
[41] REN N,JIN C S,ZHAO X Q,et al.Preterm neonate with a large congenital hemangioma on maxillofacial site causing thrombocytopenia and heart failure:A case report[J].World J Clin Cases,2022,10(17):5756-5763.
[42] REN Z,SUN S,YE Z,et al.Congenital hemangioma causing heart failure[J].Intensive Care Med,2019,45(6):889-891.
[43] 卡波西样血管内皮瘤诊疗专家共识小组.卡波西样血管内皮瘤诊疗中国专家共识(2023)[J].中华小儿外科杂志,2024,45(1):1-9.
[44] YANG K,QIU T,ZHOU J,et al.Blockage of glycolysis by targeting PFKFB3 suppresses the development of infantile hemangioma[J].J Transl Med,2023,21(1):85.
[45] KOMAKECH D,SSENKUMBA B.Pyogenic granuloma[J].N Engl J Med,2022,387(21):1979.
[46] PALETI S,FISCHER E G,RUSTAGI T.Duodenal pyogenic granuloma[J].Clin Gastroenterol Hepatol,2021,19(7):e73.
[47] 吴健平,张莉,葛宏松.儿童化脓性肉芽肿的皮肤镜和皮肤超声的特征分析[J].安徽医学,2024,45(6):742-745.
[48] COOKE-BARBER J,KREIMER S,PATEL M,et al.Venous malformations[J].Semin Pediatr Surg,2020,29(5):150976.
[49] RINALDI G,BATUL SYED S.Laser for vascular anomalies:Successful outcomes in children[J].Clin Exp Dermatol,2020,45(2):141-146.
[50] TIAN X,YU D,ZHAO X.Multidisciplinary treatment of a giant maxillofacial congenital hemangioma with multiple severe complications[J].J Craniofac Surg,2023,34(4):e385-e387.
[51] WEI H,LI Y,LI L,et al.Novel organoid construction strategy for non-involuting congenital hemangioma for drug validation[J].J Biol Eng,2023,17(1):32.

先天性血管瘤的研究进展

Research progress of congenital hemangioma

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