基于红细胞膜修饰的聚合物载体搭载的纳米靶向药物在骨再生和血管生成中的作用

doi:10.20223/j.cnki.1000-8535.2025.12.002

广州医药 ›› 2025, Vol. 56 ›› Issue (12): 1621-1629.DOI: 10.20223/j.cnki.1000-8535.2025.12.002

基于红细胞膜修饰的聚合物载体搭载的纳米靶向药物在骨再生和血管生成中的作用

王涛¹, 刘法鑫¹, 廖育豪¹, 严瀚², 黄磊¹

1 华南理工大学附属第二医院（广州市第一人民医院）口腔科（广东广州 510180）
2 华南理工大学附属第二医院（广州市第一人民医院）骨科（广东广州 510180）

收稿日期:2025-08-14 出版日期:2025-12-20 发布日期:2026-01-20
通讯作者: 黄磊,E-mail：huangleikmmc@qq.com
基金资助:
广东省自然科学基金面上项目（2022A1515012329）; 广州市卫生健康科技项目（20231A011007）

Bone-targeted nanomedicine based on red blood cell membrane-coated polymeric carriers for bone regeneration and vascularization

WANG Tao¹, LIU Faxin¹, LIAO Yuhao¹, YAN Han², HUANG Lei¹

1 Department of Stomatology,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China
2 Department of Orthopedics,Guangzhou First People's Hospital,the Second Affiliated Hospital,School of Medicine,South China University of Technology,Guangzhou 510180,China

Received:2025-08-14 Online:2025-12-20 Published:2026-01-20

摘要/Abstract

摘要： 目的开发一种多功能纳米颗粒输送系统来刺激骨再生和血管形成,用于逆转骨质疏松症。方法通过制备基于外消旋聚乳酸 Poly（D,L-lactide）即PLA的纳米颗粒来封装淫羊藿苷。随后,通过红细胞膜包被这些纳米颗粒以增强生物相容性。为了提高靶向特异性,进一步合成了由阿仑膦酸盐修饰的聚乙二醇-磷脂酰乙醇胺（PEG-DSPE）组成的骨靶向聚合物脂质,并将其掺入细胞膜涂层中。结果多功能纳米颗粒输送系统可通过调节骨髓间充质干细胞（BMSC）功能,从而增强成骨和血管生成能力。结论本研究结果表明,多功能纳米颗粒输送系统可以在体外刺激骨形成和血管形成,表明其有成为骨质疏松症先进治疗策略的潜力。

关键词: 骨质疏松症, 骨再生, 血管化, 纳米颗粒

Abstract: Objective To developed a multifunctional nanoparticle system to stimulate bone regeneration and vascularization as a therapeutics strategy for osteopovost．Methods Poly（D,L-lactide）（PLA）-based nanoparticles were fabricated to encapsulate the icariin,which is renowned for its osteogenic potential．These nanoparticles were then coated with red blood cell membranes to enhance biocompatibility．To further improve targeting specificity,a bone-targeted polymer-lipid consisting of alendronate-modified PEG-DSPE was synthesized and incorporated into the cell membrane coating．Results The delivery system was designed to modulate the function of bone marrow mesenchymal stem cells,thereby enhancing both osteogenesis and angiogenesis．Conclusions Our findings demonstrated that the therapeutic system could enhance bone formation and vascularization in vitro,indicating its potential as an advanced treatment strategy for osteoporosis．

Key words: osteoporosis, bone regeneration, vascularization, nanoparticles

王涛, 刘法鑫, 廖育豪, 严瀚, 黄磊. 基于红细胞膜修饰的聚合物载体搭载的纳米靶向药物在骨再生和血管生成中的作用[J]. 广州医药, 2025, 56(12): 1621-1629.

WANG Tao, LIU Faxin, LIAO Yuhao, YAN Han, HUANG Lei. Bone-targeted nanomedicine based on red blood cell membrane-coated polymeric carriers for bone regeneration and vascularization[J]. Guangzhou Medical Journal, 2025, 56(12): 1621-1629.

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基于红细胞膜修饰的聚合物载体搭载的纳米靶向药物在骨再生和血管生成中的作用

Bone-targeted nanomedicine based on red blood cell membrane-coated polymeric carriers for bone regeneration and vascularization

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