关键词: 脓毒性休克, TRAF6, ChE, APACHE Ⅱ评分

Abstract: Objective To explore the predictive value of tumor necrosis factor receptor associated factor 6（TRAF6）,cholinesterase（ChE）and Acute Physiology and Chronic Health Evaluation II scove（APACHE II）for adverse prognosis in patients with septic shock．Methods The clinical data of 226 patients with septic shock admitted to the Intensive Care Unit（ICU） of a hospital from February 2023 to March 2024 were retrospectively analyzed,and the patients were divided into a good prognosis group（n=151）and an adverse prognosis group（n=75）based on their prognosis．The expression of TRAF6 and ChE in 226 patients with septic shock was reviewed at admission and after treatment,while the dynamic changes of APACHE II score and Sequential Organ Failure Assessment（SOFA）score were recorded．Detailed clinical data of the two groups were compared and analyzed to explore the correlation between TRAF6,ChE,APACHE II scores and the clinical evaluation value of the above indexes in the prognosis of patients with septic shock．Logistic regression was used to analyze the potential factors affecting the survival of septic shock patients．Results Multiple Logistic regression analysis revealed that age,APACHE II score,SOFA score,mechanical ventilation time,TRAF6 and ChE expression levels were independent risk factors for prognosis（P<0.05）．Receiver Operating Characteristic（ROC）curve analysis showed that the area under curve（AUC）was 0.925,which was higher than single index prediction（0.689,0.783,0.794,0.781,0.708 and 0.827）．Conclusions High-risk patients with advanced age,prolonged mechanical ventilation,high APACHE II and SOFA scores,and high TRAF6 and ChE expression levels need to be identified in time．TRAF6,ChE expression levels,SOFA scores,and APACHE II scores can be used as clinical indicators to evaluate the prognosis of septic shock patients．The combined application of those four indicators can further improve the clinical value．

Key words: septic shock, TRAF6, ChE, APACHE II score