关键词: 2型糖尿病, 葡萄糖目标范围内时间, 高尿酸血症, 相关性, 严重程度

Abstract: Objective To explore the correlation between time in range（TIR）of glucose and hyperuricemia（HUA）in patients with type 2 diabetes mellitus（T2DM）．Methods From October 2021 to October 2024,110 patients with T2DM complicated with HUA admitted to our hospital were divided into T2DM with HUA group,and 110 patients with T2DM only in the same period were divided into T2DM group．The general data and laboratory related indicators of the two groups were compared,and the influencing factors of the occurrence of HUA in T2DM patients were analyzed by logistic regression model．Subsequently,110 patients with T2DM complicated with HUA were divided into mild group（58 cases）,moderate group（37 cases）,and severe group（15 cases）according to their severity．The clinical related indicators and TIR levels of the three groups were compared,and the correlation between clinical related indicators and TIR levels and the severity of HUA in T2DM patients was analyzed．Results Body mass index（BMI）,glycosylated hemoglobin,total cholesterol,triglyceride,and blood creatinine（Scr）between T2DM with HUA group and T2DM group were significantly different（P<0.05）．The indicators with statistical differences were included in the logistics regression model to determine whether to merge HUA as the dependent variable（with HUA=1,without HUA=0）．The results showed that,BMI,glycosylated hemoglobin,total cholesterol,triglycerides,Scr,and TIR were important influencing factors for the occurrence of HUA in T2DM patients（P<0.05）．Comparison of clinical indicators and TIR levels in patients with different degrees of HUA revealed no significant differences in glycosylated hemoglobin,total cholesterol,triglycerides,and Scr levels among the mild,moderate,and severe groups（P>0.05）,while there were significant differences in BMI and TIR levels among the mild,moderate,and severe groups（P<0.05）．The difference between the severe group and the mild group was statistically significant（P<0.05）,and the difference between the severe group and the moderate group was statistically significant（P<0.05）．The Spearman correlation analysis results showed that BMI was positively correlated with the severity of HUA,while TIR was negatively correlated with the severity of HUA（P<0.05）．Conclusions The decrease of TIR is one of the important influencing factors of HUA in T2DM patients,and the level of TIR is closely related to the severity of HUA．

Key words: type 2 diabetes mellitus, time in range of glucose, hyperuricemia, relevance, severity level