关键词: 非霍奇金淋巴瘤, PG-SGA, 营养评估, 化疗后感染, 平均住院日

Abstract: Objective To explore the effects of nutritional assessment and inflammatory factor levels on post-chemotherapy infections and length of hospital stay in patients with non-Hodgkin’s lymphoma（NHL）．Methods A total of 95 NHL patients treated with the R-CHOP regimen were retrospectively analyzed．The cut-off value of Patient-Generated Subjective Global Assessment （PG-SGA） for post-chemotherapy infection in NHL patients was evaluated by Receiver Operating Characteristic（ROC）curves．Patients were categorized into PG-SGA<4 and PG-SGA≥4 groups and compared for differences of nutritional and inflammation-related factors．Univariate and multivariate logistic regression were used to analyze the risk factors for post-chemotherapy infection and length of hospital stay（LHS）．Results The ROC curve showed that the Youden index was largest at PG-SGA of 3.5,which predicted post-chemotherapy infection in NHL patients with a sensitivity of 92% and a specificity of 11.1%． The mean age,International Prognostic Index（IPI）,and Ann Arbor stage Ⅲ~IV proportion in patients with PG-SGA≥4 were higher compared with the control（P<0.05）．Patients with PG-SGA≥4 had significantly higher interleukin-6 and neutrophil-to-lymphocyte ratio（NLR）,and the infection rate and the proportion of LHS≥5 days after chemotherapy were higher than those in the control group（P<0.05）．Patients in the PG-SGA<4 group had significantly higher prealbumin,albumin,and hemoglobin levels compared to the PG-SGA≥4 group（P<0.05）．Multifactorial logistic regression analysis revealed that PG-SGA≥4 and combined diabetes mellitus were independent risk factors for post-chemotherapy infection rate in NHL patients（both P<0.05）．Albumin less than 35 g/L and combined post-chemotherapy infection were independent risk factors for prolonged LHS in NHL patients（both P<0.05）．Conclusions PG-SGA nutritional assessment and inflammatory factor analysis are clinically instructive in predicting post-chemotherapy infections and LHS in NHL patients．

Key words: non-Hodgkin’s lymphoma, PG-SGA, nutritional assessment, post-chemotherapy infection, length of hospital stay