长链非编码RNA在消化道肿瘤中的研究进展

doi:10.20223/j.cnki.1000-8535.2024.10.001

广州医药 ›› 2024, Vol. 55 ›› Issue (10): 1105-1112.DOI: 10.20223/j.cnki.1000-8535.2024.10.001

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长链非编码RNA在消化道肿瘤中的研究进展

邹炳旭, 王凤伟, 谢丹

中山大学肿瘤防治中心,华南恶性肿瘤防治全国重点实验室（广东广州 510060）

收稿日期:2024-08-07 出版日期:2024-10-20 发布日期:2024-11-05
通讯作者: 谢丹,E-mail：xiedan@sysucc.org.cn
作者简介:谢丹教授,博士生导师; 中山大学-肿瘤防治中心“华南肿瘤学国家重点实验室”项目组长（PI）,病理科副主任,国家杰出青年基金项目获得者（2012年）,广东省“珠江学者特聘教授”（2013年）,科技部“中青年领军人才”（2014年）,国家万人计划“科技创新领军人才”（2016年）,国家重点研发计划项目“首席科学家”（2017年）; 现任广东省抗癌协会-癌转移学会副主任委员;
主要研究方向：运用分子病理学和实验肿瘤学等相关技术,进行结直肠癌和肝癌等多种人类消化系统肿瘤侵袭和转移分子机制和分子诊断标志物的研究; 相关研究成果以第一作者或通讯作者分别发表在Lancet Oncol、Nature Cell Biol、Gut、J Clin Invest、Cell Res、Nature Comm、Signal Transduction and Targeted Therapy、Cancer Res等杂志上; 先后主持国家和部省级等科研课题20余项; 在肿瘤病理学领域的相关主流学术（SCI收录）杂志上共发表SCI论著200余篇,其中通讯/共同通讯作者论著100余篇,第一/共同第一作者论著6篇,累计影响因子（IF）超过1 000多分; 获得肿瘤诊断标志物相关的专利5项
基金资助:
国家自然科学基金面上项目（82072608）

Long non-coding RNAs in human gastrointestinal cancer

ZOU Bingxu, WANG Fengwei, XIE Dan

State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou 510060,China

Received:2024-08-07 Online:2024-10-20 Published:2024-11-05

摘要/Abstract

摘要： 在过去的几十年中,随着RNA生物学的深入研究,越来越多的证据表明,非编码RNA（ncRNA）对包括癌症在内的多种疾病进展起着关键作用,同时在作为生物标志物和治疗靶点方面表现出了巨大的潜力。在全球范围内,消化道（GI）肿瘤是肿瘤相关死亡的主要原因,目前消化道肿瘤晚期患者的生存率依然很低。既往大量研究报道了ncRNA中,特别是长链非编码RNA（lncRNA）在消化道肿瘤发生发展中发挥重要作用。本文将着重阐述lncRNA在消化道肿瘤分子生物学中的作用,旨在为深入理解lncRNA在消化道肿瘤发生发展机制以及临床转化应用提供新的思路和线索。

关键词: 长链非编码RNA, 消化道肿瘤, 作用机制, 基因调控

Abstract: In recent decades,an increasing body of evidence has pointed to the pivotal roles of non-coding RNAs（ncRNAs）,particularly long non-coding RNAs（lncRNAs）,in the development of various diseases,including cancer．Meanwhile,ncRNAs have been shown great potential as biomarker and therapeutic target．Gastrointestinal（GI）cancers are a leading cause of cancer-related mortality globally and the survival rate of advanced GI cancer patients is still very low．Extensive research has underscored the significant involvement of lncRNAs in the initiation and progression of GI cancers．This review aims to offer a comprehensive overview of lncRNAs,shedding light on their roles in the molecular biology of GI cancers．By synthesizing previous studies,this review seeks to provide new insights into the mechanisms underlying lncRNAs' contribution to GI cancer development and their potential clinical applications．

Key words: long non-coding RNAs, gastrointestinal cancer, mechanisms, regulation of gene expression

邹炳旭, 王凤伟, 谢丹. 长链非编码RNA在消化道肿瘤中的研究进展[J]. 广州医药, 2024, 55(10): 1105-1112.

ZOU Bingxu, WANG Fengwei, XIE Dan. Long non-coding RNAs in human gastrointestinal cancer[J]. Guangzhou Medical Journal, 2024, 55(10): 1105-1112.

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长链非编码RNA在消化道肿瘤中的研究进展

Long non-coding RNAs in human gastrointestinal cancer

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