ε-3多不饱和脂肪酸减低胃肠道肿瘤患者化疗后胃肠道及全身炎症因子反应

doi:10.3969/j.issn.1000-8535.2016.02.022

广州医药 ›› 2016, Vol. 47 ›› Issue (2): 66-68.DOI: 10.3969/j.issn.1000-8535.2016.02.022

ε-3多不饱和脂肪酸减低胃肠道肿瘤患者化疗后胃肠道及全身炎症因子反应

程艳华, 刘丽兰, 朱国栋, 朱志刚, 曹小飞

广州市第一人民医院(广州 510180)

收稿日期:2015-11-06 出版日期:2016-03-20 发布日期:2021-11-30
通讯作者: 程艳华,E-mail:929358663@qq.com

The effect of omega-3 polyunsaturated fatty acid on gastrointestinal toxicity and systemic inflammatory response induced by chemotherapy for patients with gastric or colorectal cancer

Cheng Yanhua, Liu Lilan, Zhu Guodong, et al

Guangzhou First People's Hospital, Guangzhou Medical University,Guangzhou 510180,China Cao Xiaofei. Department of Oncology, Guangzhou First People's Hospital, Guangzhou Medical University,Guangzhou510180,China

Received:2015-11-06 Online:2016-03-20 Published:2021-11-30

摘要/Abstract

摘要： 目的探讨ε-3多不饱和脂肪酸在胃肠道肿瘤患者化疗后的胃肠道毒性及生活质量的作用。方法在研究前经过化疗筛选,按照WHO化疗副反应在2级或者以上的50名住院的胃癌或者直结肠癌患者,随机分为对照组(单纯化疗)(n=25)和研究组(化疗加ε-3多不饱和脂肪酸)(n=25),两组的化疗方案均为化疗筛选的方案。预防性每天静脉使用ε-3多不饱和脂肪酸 200 mg,连续5天,记录评估胃肠道并发症,如恶心、呕吐和腹泻,以及KPS评分、血清白蛋白、IL-2、IFN-γ和CRP。结果与对照组比较,恶心、呕吐和腹泻评分、IL-2、IFN-γ和CRP低于于对照组,相反,生活质量评分研究组高于对照组,差异有统计学意义(P<0.05)。结论预防性使用ε-3多不饱和脂肪酸能够减轻胃肠道肿瘤患者化疗后的胃肠道毒性症状、降低全身炎症因子反应并改善生活质量。

关键词: ε-3多不饱和脂肪酸, 胃肠道毒性, 化疗, 生活质量, 消化道肿瘤

Abstract: Objective To explore the effect omega-3polyunsaturated fatty acid omega-3 FA on clinical manifestations of gastrointestinal toxicity and quality of life (QOL) induced by chemotherapy for patients with gastric or colorectal cancer. Methods After screening chemotherapy, Fifty patients with gastric or colorectal cancer, according to developing WHO side-effect grading system of grade 2 or higher were randomly divided into either control group (n=25) or omega-3 FAs group (n=25) during next cycle of chemotherapy. In the control group, the patients received the same chemotherapy regimens as screening cycle and in the omega-3 FA group, received chemotherapy and omega-3 FAs. Prophylactic intravenous 200 mL /d was given for 5 days. The gastrointestinal complications such as nausea,vomiting or diarrhoea and Karnofsky performance status(KPS ),IL-2,IFN-γandCRP,ect, were evaluated respectively. Results Compared with the control group, the scores of nausea vomiting and diarrhea and IL-2,IFN-γor CRP levels decreased , significantly,on the contrary, the score of QOL increased. There was significantly statistical difference (P<0.05). Conclusion Prophylactic intravenous omega-3 FA can ameliorate clinical manifestations of gastrointestinal toxicity and systemic inflammatory response syndrome(SIRS) induced by chemotherapy and improve QOL for patients with gastric or colorectal cancer.

Key words: Omega-3polyunsaturated fatty acid, Gastrointestinal toxicity, Chemotherapy, quality of life, Gastrointestinal tract tumor

程艳华, 刘丽兰, 朱国栋, 朱志刚, 曹小飞. ε-3多不饱和脂肪酸减低胃肠道肿瘤患者化疗后胃肠道及全身炎症因子反应[J]. 广州医药, 2016, 47(2): 66-68.

Cheng Yanhua, Liu Lilan, Zhu Guodong, et al. The effect of omega-3 polyunsaturated fatty acid on gastrointestinal toxicity and systemic inflammatory response induced by chemotherapy for patients with gastric or colorectal cancer[J]. Guangzhou Medical Journal, 2016, 47(2): 66-68.

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ε-3多不饱和脂肪酸减低胃肠道肿瘤患者化疗后胃肠道及全身炎症因子反应

The effect of omega-3 polyunsaturated fatty acid on gastrointestinal toxicity and systemic inflammatory response induced by chemotherapy for patients with gastric or colorectal cancer

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