广东粤西北农村妇女高危型HPV感染情况分析

doi:10.3969/j.issn.1000-8535.2022.06.005

广州医药 ›› 2022, Vol. 53 ›› Issue (6): 22-26.DOI: 10.3969/j.issn.1000-8535.2022.06.005

广东粤西北农村妇女高危型HPV感染情况分析

黄千峰¹, 何琴¹, 何裕¹, 邓娟琼², 林杏芳², 张秀¹

1 广东省妇幼保健院体检科(广州 511400)
2 广东省肇庆市怀集县妇幼保健院社会服务部(肇庆 526400)

收稿日期:2022-01-12 出版日期:2022-11-20 发布日期:2022-11-30
通讯作者: 张秀,E-mail: 51648625@qq.com
基金资助:
中国疾病预防控制中心妇幼保健中心科研项目(2019FYH003)

Analysis of high-risk HPV infection among rural women in northwestern Guangdong

HUANG Qianfeng¹, HE Qin¹, HE Yu¹, DENG Juanqiong², LIN Xingfang², ZHANG Xiu¹

1 Department of Physical Examination,Guangdong Women and Children Hospital,Guangzhou 511400,China
2 Department of Social Service,Huaiji Women and Children Hospital,Zhaoqing 526400,China

Received:2022-01-12 Online:2022-11-20 Published:2022-11-30

摘要/Abstract

摘要： 目的了解广东肇庆怀集县农村妇女两年来“两癌”检测的阳性情况及高危型人乳头瘤病毒(HPV)的感染特点。方法对2018年1月—2019年12月24 146名参与“两癌”免费检测的35~64 岁、农村妇女的宫颈癌筛查结果进行分析。以高危型HPV检测作为初筛方法,结果为HPV16、18型阳性的转诊阴道镜检查,其它高危型HPV阳性则进行薄层宫颈液基细胞学检查(TCT),TCT结果严重于或等于未明确意义的非典型鳞状上皮(ASC-US)者转诊阴道镜,阴道镜结果可疑或异常者进行组织病理学检查。结果高危型HPV总检出率为9.35%,单独HPV16、18和其它高危型HPV的阳性检出率分别为0.70%、0.32%、7.72%,混合感染检出率为0.61%,高危型 HPV 总检出率最高的年龄段是 60~64岁,检出率为11.22%。细胞学转诊率为65.63%,阴道镜转诊率为61.23%。宫颈癌前病变检出率为323.03/10 万,宫颈癌的检出率为45.56/10 万,早期诊断率为87.64%。宫颈癌前病变和宫颈癌的HPV16、18及混合感染占70.79%。结论该地区高危型HPV阳性率、宫颈癌前病变及宫颈癌检出率均较高,宫颈癌筛查异常者细胞学及阴道镜转诊率较低,提示该地区存在更高的宫颈癌发病风险。

关键词: 农村妇女, 宫颈癌筛查, 高危型人乳头瘤病毒

Abstract: Objective To understand the positive screening results and the infection characteristics of high-risk human papillomavirus (HPV) in Huaiji County,Guangdong Province,in the two years of the free standardization testing for rural women's “two cancers”. Methods The cervical cancer screening results of 35~64 year-old women with rural household registration who volunteered to participate in the “two cancers” free testing for rural women in the region were analyzed. High-risk HPV testing was used as the primary screening method for cervical cancer. The results of HPV16 and 18 positive patients were directly referred to colposcopy. If other high-risk HPV was positive,thin-layer cervical fluid-based cytology(TCT) was perform on those patients,whose TCT result severer than atypical squamous cells of undetermined significance (ASC-US) were referred to colposcopy,and those with suspicious or abnormal colposcopy results were referred to histopathological examination. Results The total positive detection rate of high-risk HPV was 9.35%. The positive rates of HPV16,18 and other high-risk HPV were 0.70%,0.32% and 7.72% respectively,mixed infection rate was 0.61%. The age group with the highest overall positive rate of high-risk HPV is 60-64 years old,and the rate is 11.22%. The referral rate for cytology was 65.63%,and the referral rate for colposcopy was 61.23%. The positive rate of cervical precancerous lesions was 323.03/100 000,the positive rate of cervical cancer was 45.5/100 000,and the early diagnosis rate was 87.64%.HPV16,18 and HPV mixed infections of cervical precancerous lesions and cervical cancer accounted for 70.79%.Conclusions The positive rate of high-risk HPV,cervical precancerous lesions and cervical cancer positive rate were high in this area. The being referred rate of cytology and colposcopy in cervical cancer screening was low,suggesting that there was a higher incidence of cervical cancer in this area risk.

Key words: postmenopausal women, cervical cancer screening, high risk HPV

黄千峰, 何琴, 何裕, 邓娟琼, 林杏芳, 张秀. 广东粤西北农村妇女高危型HPV感染情况分析[J]. 广州医药, 2022, 53(6): 22-26.

HUANG Qianfeng, HE Qin, HE Yu, DENG Juanqiong, LIN Xingfang, ZHANG Xiu. Analysis of high-risk HPV infection among rural women in northwestern Guangdong[J]. Guangzhou Medical Journal, 2022, 53(6): 22-26.

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广东粤西北农村妇女高危型HPV感染情况分析

Analysis of high-risk HPV infection among rural women in northwestern Guangdong

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