川崎病冠脉损伤与血清1,25(OH)2D3水平关系

doi:10.3969/j.issn.1000-8535.2022.06.004

广州医药 ›› 2022, Vol. 53 ›› Issue (6): 18-21.DOI: 10.3969/j.issn.1000-8535.2022.06.004

川崎病冠脉损伤与血清1,25(OH)₂D₃水平关系

陈艳丽

西安医学院第一附属医院(西安 710077)

收稿日期:2021-11-25 出版日期:2022-11-20 发布日期:2022-11-30
基金资助:
陕西省重点研发计划(2017SF-055)

The relationship between coronary artery injury and serum 1,25(OH)₂D₃ level in Kawasaki disease

CHEN Yanli

Department of Pediatrics,The First Affiliated Hospital of Xi'an Medical University,Xi'an 710077,China

Received:2021-11-25 Online:2022-11-20 Published:2022-11-30

摘要/Abstract

摘要： 目的通过测定川崎病(KD)患儿血清1,25(OH)₂D₃水平,探讨其与冠脉损伤(CAL)之间的关系。方法选取在我院儿科住院的KD患儿200例,依据是否发生CAL分成CAL组(172例)和非冠脉损伤组(NCAL,28 例),并分别检测静脉内丙种球蛋白(IVIG)注射前后血清1,25(OH)₂D₃水平。选取35例健康儿童作为对照组,检测其血清1,25(OH)₂D₃水平,并进行比较。结果 IVIG输注前:CAL组和NCAL组血清1,25(OH)₂D₃水平较对照组低下(P＜0.05),CAL组最低(P＜0.05);IVIG输注后:NCAL组血清1,25(OH)₂D₃水平与对照组相比,差异无统计学意义(P＞0.05),CAL组血清1,25(OH)₂D₃水平较NCAL组和对照组低(P＜0.05);IVIG输注前后比较:CAL组和NCAL组血清1,25(OH)₂D₃水平在IVIG输注后均较输注前升高(P<0.001)。结论 KD患儿血清1,25(OH)₂D₃水平低下,而且血清1.25(OH)₂D₃水平越低,出现CAL的几率越大。

关键词: 川崎病, 冠脉损伤, 1,25(OH)₂D₃

Abstract: Objective The serum level of 1,25(OH)₂D₃ was detected to investigate the its relationship with coronary artery lesion (CAL) in children with Kawasaki disease (KD).Methods A total of 200 children with KD in our hospital were divided into CAL group (172 cases) and no CAL group (NCAL,28 cases) according to the CAL situation.Serum 1,25(OH)₂D₃ level before and after intravenous immunoglobulin (IVIG) injection was detected respectively.While 35 healthy children were enrolled as control group, comparing with KD children.Results Before IVIG injection,the levels of 1,25(OH)₂D₃ in the CAL and NCAL groups were lower than that in the control group (P＜0.05),and which in the CAL group was the lowest (P＜0.05).After IVIG injection,the level of 1,25(OH)₂D₃ showed no significant difference between the NCAL group and the control group (P＞0.05),and the level of 1,25(OH)₂D₃ in CAL group was lower than that in the NCAL group and control group (P＜0.05).Serum 1,25(OH)₂D₃ level in both CAL and NCAL groups increased after IVIG injection compared with that before injection (P<0.001).Conclusions The serum 1,25(OH)₂D₃ level was low in children with KD,and the lower serum 1,25(OH)₂D₃ level,the higher the incidence of CAL.

Key words: Kawasaki disease, coronary artery lesion, 1,25(OH)₂D₃

陈艳丽. 川崎病冠脉损伤与血清1,25(OH)₂D₃水平关系[J]. 广州医药, 2022, 53(6): 18-21.

CHEN Yanli. The relationship between coronary artery injury and serum 1,25(OH)₂D₃ level in Kawasaki disease[J]. Guangzhou Medical Journal, 2022, 53(6): 18-21.

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川崎病冠脉损伤与血清1,25(OH)₂D₃水平关系

The relationship between coronary artery injury and serum 1,25(OH)₂D₃ level in Kawasaki disease

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