老年食管鳞癌患者单纯放疗和同步放化疗的临床观察

doi:10.3969/j.issn.1000-8535.2022.02.008

摘要/Abstract

摘要： 目的探究老年食管鳞癌患者单纯放疗、同步放化疗临床治疗效果。方法选我院2018年1月—2020年12月期间90例老年食管鳞癌患者为研究对象,依据不同治疗方式将其分为对照组、观察组,各45例,分别接受单纯放疗、同步放化疗治疗,比较2组治疗效果及治疗安全性。结果观察组治疗总有效率为75.56%,与对照组60.00%相近(P＞0.05);观察组疾病控制率为97.78%,较对照组84.44%高(P＜0.05);观察组放射性肺炎、骨髓抑制发生率为24.44%、77.78%,较对照组6.67%、48.89%高;且观察组放射性肺炎、骨髓抑制、放射性食管炎2级占比分别为17.78%、35.56%、57.78%,均较对照组2.22%、8.89%、24.44%高(P＜0.05)。结论在老年食管鳞癌患者治疗中,与单纯放疗相比,同步放化疗可提升疾病控制能力,但会增加治疗不良反应,增加不良反应严重程度,因此在临床治疗中,需慎重选择。

关键词: 老年食管鳞癌, 放疗, 同步放化疗

Abstract: Objective To explore the clinical effect of radiotherapy only and concurrent chemoradiotherapy in elderly patients with esophageal squamous cell carcinoma. Methods Ninety cases of elderly patients with esophageal squamous cell carcinoma in our hospital from January 2018 to December 2020 were selected as research objects.According to different treatment methods, they were divided into control group and observation group, 45 cases in each group.They were treated with radiotherapy and concurrent chemoradiotherapy respectively.The treatment effect and safety of the two groups were compared. Results The total effective rate of the observation group was 75.56%, which was close to the control group (60.00%, P>0.05). The disease control rate of the observation group was 97.78%, which was higher than control group (84.44%, P<0.05). The incidence of radiation pneumonia and bone marrow suppression of the observation group were 24.44% and 77.78%, which were higher than that of the control group (6.67%, 48.89%). The proportion of radiation pneumonia, bone marrow suppression, radiation esophagitis grade 2 of the observation group were 17.78%, 35.78% and 57.78% respectively, higher than that of the control group (2.22%, 8.89%, 24.44% respectively, P<0.05). Conclusion Compared with radiotherapy only, concurrent chemoradiotherapy improved the ability of disease control in elderly patients with esophageal squamous cell carcinoma, but it increased the adverse reactions and aggravated the severity of adverse reactions.Therefore, it is necessary to make a careful choice in clinical treatment.

Key words: elderly esophageal squamous cell carcinoma, radiotherapy, concurrent chemoradiotherapy

刘月娟. 老年食管鳞癌患者单纯放疗和同步放化疗的临床观察[J]. 广州医药, 2022, 53(2): 35-38.

LIU Yuejuan. Clinical observation of radiotherapy only and concurrent chemoradiotherapy in elderly patients with esophageal squamous cell carcinoma[J]. Guangzhou Medical Journal, 2022, 53(2): 35-38.

参考文献

[1] 赵斌,陈飒,南媛.1999-2018年陕西省肿瘤医院恶性肿瘤住院病例回顾性研究[J].现代预防医学, 2020, 47(3):194-198.
[2] 曾程,杨丹,杜荣旭,等.局部晚期不可手术食管癌同步放化疗联合尼妥珠单抗的初步临床分析[J].中华放射肿瘤学杂志, 2021, 30(4):353-356.
[3] 倪文婕,于舒飞,杨劲松,等.局部晚期食管癌根治术后放疗同步周方案化疗的耐受性研究[J].华肿瘤杂志, 2019, 41(6):415-420.
[4] 姜万荣,刘凤,周彬,等.65～75岁胸段食管鳞癌患者根治术后放疗的临床观察[J].临床肿瘤学杂志, 2020, 25(1):26-32.
[5] 中国抗癌协会食管癌专业委员会编.食管癌规范化诊治指南[M].北京:中国协和医科大学出版社, 2013.
[6] 戴婷婷,王万伟,仝宇梭,等.多西他赛联合顺铂同步放化疗和单纯放疗治疗老年非手术食管鳞癌的临床疗效分析[J].实用癌症杂志, 2019, 34(3):417-420.
[7] 钱军,邹黎.卡培他滨联合顺铂化疗同步放疗对食管癌临床疗效的研究[J].现代医学, 2019, 47(7):73-77.
[8] 杜文静,顾晓斌,高献书,等.食管鳞癌诱导化疗联合调强放疗治疗模式探讨及预后分析[J].中华放射医学与防护杂志, 2019, 39(12):920-925.
[9] 张小杰.紫杉醇和顺铂在老年食管癌患者治疗中的疗效观察[J].山西医药杂志, 2020,49(7):821-823.
[10] 宋玉芝,李润霄,甄婵军,等.紫杉醇联合卡铂同期放化疗治疗食管癌的临床研究[J].重庆医学, 2019, 48(12):61-64,69.
[11] 王涛,李颖,张西志,等.不可切除食管癌紫杉烷或氟尿嘧啶类联合铂类同步放化疗荟萃分析[J].中华肿瘤防治杂志, 2020,27(4):316-325.
[12] 薛晓婕,尹建军.SAHA联合顺铂对食管癌ECA-109细胞系抑制协同作用及机制研究[J].中华肿瘤防治杂志, 2019, 26(18):25-31.
[13] 周彬,傅辰春,孙新臣,等.老年食管鳞癌患者单纯放疗和同步放化疗的有效性和安全性比较[J].临床肿瘤学杂志, 2020, 25(2):71-76.