镇痛活络酊和外用非甾体抗炎药治疗肱骨外上髁炎的短期疗效对比研究

doi:10.3969/j.issn.1000-8535.2020.05.029

广州医药 ›› 2020, Vol. 51 ›› Issue (5): 123-129.DOI: 10.3969/j.issn.1000-8535.2020.05.029

镇痛活络酊和外用非甾体抗炎药治疗肱骨外上髁炎的短期疗效对比研究

贾梦岩¹, 肖军²

1 广州市第一人民医院骨科(广州 510180)
2 南方医科大学南方医院骨科(广州 510515)

收稿日期:2020-03-02 出版日期:2020-09-20 发布日期:2021-11-28
通讯作者: 肖军,E-mail:orthopaedxj@163.com

Short-term effects comparison between analgesic tincture and topical nonsteroidal anti-inflammatory drugs in the treatment of lateral epicondylitis

JIA Mengyan¹, XIAO Jun²

1 Department of Orthopaedic Surgery, Guangzhou First People's Hospital, Guangzhou 510180,China
2 Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515,China

Received:2020-03-02 Online:2020-09-20 Published:2021-11-28

摘要/Abstract

摘要： 目的对比中成药镇痛活络酊和非甾体抗炎药(Nonsteroidal Anti-inflammatory Drugs,NSAIDs)治疗肱骨外上髁炎(lateral epicondylitis,LE)的短期临床疗效差异。方法筛选后符合纳入标准的LE患者60例,随机分为镇痛活络酊组(n=30)和NSAIDs组(n=30)。镇痛活络酊组外用镇痛活络酊,NSAIDs组外用法斯通凝胶(酮洛芬),两组均连续用药3周,3次/d。用药后3 周、6 周和12 周连续随访,主要观测指标包括视觉模拟评分(visual analog scale,VAS);肩、肘和手的功能评分(Disabilities of the arm, Shoulder And Hand,DASH);无痛握力(Pain-free grip strength,PFGS)。VAS评分分别测量患者1周前用力活动时的VAS评分和正常休息时的VAS评分,记为VAS(活动时)和VAS(休息时)。运用统计学方法对比分析两组患者在VAS评分(活动时)、VAS评分(休息时)、DASH评分和PFGS上的差异。结果两组患者在VAS评分(活动时)、VAS评分(休息时)和DASH评分上均未见组间差异(P>0.05)。两组患者在用药前、用药后3周、用药后6周的PGFS对比同样无组间差异(P=0.91,P=0.42,P=0.13)。但是,在用药后12周,镇痛活络酊组的PFGS高于NSAIDs组(P=0.02)。结论镇痛活络酊缓解LE疼痛的效果与外用NSAIDs相当,对提升伸肌力效果则更优。

关键词: 肱骨外上髁炎, 镇痛活络酊, 非甾体类抗炎药

Abstract: Objective To compare the short-term clinical effects difference between analgesic tincture and topical nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of lateral epicondylitis (LE). Methods 60 cases of LE patients were randomly divided into an analgesic tincture group (n=30) and a NSAIDs group (n=30). Analgesic tincture was chosen for the analgesic tincture group and topical ketoprofen gel for the NSAIDs group to treat LE. Two groups were treated continuously for 3w, 3 times/day. Clinical results of each drug were followed-up at the time point of 3w, 6w and 12w after usage. Observational indexes included the visual analogue scale (VAS), disabilities of the arm, shoulder and hand questionnaire (DASH) and pain-free grip strength (PFGS). The inter-group difference of VAS (at activity), VAS (at rest), DASH score and PFGS were compared subsequently. Results No difference of the VAS (at activity), VAS (at rest), DASH score were ascertained (P> 0.05) between groups. Inter-group difference of PGFS was also not discerned at the time points of pre-treatment and 3 weeks and 6 weeks (P=0.91, P=0.42, P=0.13) post-treatment. However, PFGS of the analgesic tincture group was found to be higher than that of the NSAIDs group (P=0.02) after 12 weeks post-treatment. Conclusion Effect of analgesic tincture in releasing pain is almost the same to that of tropical NSAIDs, but a better effect in improving muscle strength.

Key words: Lateral epicondylitis, Analgesic tincture, NSAIDs

贾梦岩, 肖军. 镇痛活络酊和外用非甾体抗炎药治疗肱骨外上髁炎的短期疗效对比研究[J]. 广州医药, 2020, 51(5): 123-129.

JIA Mengyan, XIAO Jun. Short-term effects comparison between analgesic tincture and topical nonsteroidal anti-inflammatory drugs in the treatment of lateral epicondylitis[J]. Guangzhou Medical Journal, 2020, 51(5): 123-129.

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镇痛活络酊和外用非甾体抗炎药治疗肱骨外上髁炎的短期疗效对比研究

Short-term effects comparison between analgesic tincture and topical nonsteroidal anti-inflammatory drugs in the treatment of lateral epicondylitis

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